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pro vyhledávání: '"Anna F. Fesser"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008487 (2020)
New assay designs are needed to improve the predictive value of the Trypanosoma cruzi in vitro tests used as part of the Chagas' disease drug development pipeline. Here, we employed a green fluorescent protein (eGFP)-expressing parasite line and live
Externí odkaz:
https://doaj.org/article/7b65573ff19249218f435af9c19dad98
Publikováno v:
Biospektrum
Chagas disease is a zoonosis caused by Trypanosoma cruzi and transmitted by triatomine bugs. Autochthonous to Latin America, Chagas disease has spread globally through travel and migration. New drugs are needed urgently, in particular drugs that cure
Autor:
Gabriel Melo de Oliveira, Aline Nefertiti Silva da Gama, Romina Rocchetti, Monica Cal, Anna F. Fesser, Raiza Brandão Peres, Maria de Nazaré Correia Soeiro, Marianne Rocha-Hasler, Ludmila Ferreira de Almeida Fiuza, Marcel Kaiser, Pascal Mäser, Xue Li Guan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T. cruzi cytochrome CYP51