Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna F. Davidson"'
Autor:
Anna F. Davidson, Linyee Shum, Paul J. Widner, Irma H. Benedek, Henry J. Pieniaszek, Walter Flamenbaum, Cynthia A. Robinson
Publikováno v:
The Journal of Clinical Pharmacology. 36:1161-1168
Sixteen healthy male volunteers completed a nonrandomized, sequential, three-phase study. The three phases were 1) moricizine at 250 mg every 8 hours for 7 days with 12 days washout; 2) diltiazem at 60 mg every 8 hours for 7 days; and 3) concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e7ed0a70c49188cd06eb35db058dbb
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 14:1717-1725
A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346d177571f40cbcc86c128f3cf36018
https://doi.org/10.1016/0731-7085(96)01794-3
https://doi.org/10.1016/0731-7085(96)01794-3
Autor:
Richard E. Sampliner, Henry J. Pieniaszek, Michael Mayersohn, Anna F. Davidson, Carol M. McEntegart, Check Y. Quon
Publikováno v:
Biopharmaceutics & Drug Disposition. 15:243-252
The pharmacokinetics of moricizine and two of its metabolites, moricizine sulfoxide and phenothiazine-2-carbamic acid ethyl ester sulfoxide, were studied in healthy control subjects and in patients with chronic liver disease (cirrhosis). Moricizine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd13c9c094e8642acb8d5192063c0d0
https://doi.org/10.1002/bdd.2510150306
https://doi.org/10.1002/bdd.2510150306
Autor:
Thomas M. Reilly, Harry L Walton, Henry J. Pieniaszek, Richard E. Olson, Anna F Davidson, Donald J. P. Pinto, Yu Chen Barrett
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 30(5)
A radioimmunoassay (RIA) was developed for the determination of XV459, the active hydrolysis metabolite of the oral prodrug roxifiban (DMP 754), in human plasma. XV459 is a potent antagonist of the glycoprotein IIb/IIIa receptor. The method utilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de4d4d0919b43afcc5469ef4bf185fc
https://pubmed.ncbi.nlm.nih.gov/12467915
https://pubmed.ncbi.nlm.nih.gov/12467915
Autor:
Anna F. Davidson, L. Shum, Michael Mayersohn, J. E. Chaney, Henry J. Pieniaszek, C. A. Robinson
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 29(9)
1. The metabolism of moricizine.HCl was studied in 12 male volunteers dosed with 250 mg (300 microCi) 14C-radiolabelled drug. 2. Moricizine was biotransformed to many metabolites in humans (at least 35 plasma and 51 urine metabolites). 3. Urine and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719d75645ed8aa81a9f47f32d88a2d85
https://pubmed.ncbi.nlm.nih.gov/10548454
https://pubmed.ncbi.nlm.nih.gov/10548454
Publikováno v:
Journal of clinical pharmacology. 34(2)
Moricizine · HCl, a novel phenothiazine derivative with oral antiarrhythmic activity, was examined for its potential to induce its own hepatic metabolism and to alter the pharmacokinetics of the test substrate, antipyrine, in 12 healthy male subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae42701102d24e6872d7f752438d342b
https://pubmed.ncbi.nlm.nih.gov/8163717
https://pubmed.ncbi.nlm.nih.gov/8163717
Publikováno v:
Therapeutic drug monitoring. 15(3)
We studied the effect of multiple oral doses of moricizine on the pharmacokinetics of theophylline in healthy male subjects. Twelve subjects initially received two single oral doses of theophylline, one in the form of immediate-release Aminophyllin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65fabe79d0dfc0c49d0971c0babb21c
https://pubmed.ncbi.nlm.nih.gov/8332999
https://pubmed.ncbi.nlm.nih.gov/8332999