Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anna F Averette"'
Autor:
Cullen Roth, Debra Murray, Alexandria Scott, Ci Fu, Anna F Averette, Sheng Sun, Joseph Heitman, Paul M Magwene
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009313 (2021)
Cryptococcal disease is estimated to affect nearly a quarter of a million people annually. Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical infections in temperate climates such as Europe, vary in their pathoge
Externí odkaz:
https://doaj.org/article/7482a7ae87754a33888615ead9d7f067
Autor:
Elizabeth J Polvi, Anna F Averette, Soo Chan Lee, Taeyup Kim, Yong-Sun Bahn, Amanda O Veri, Nicole Robbins, Joseph Heitman, Leah E Cowen
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006350 (2016)
Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in
Externí odkaz:
https://doaj.org/article/89815a9598c440b8a4db298d41a828d9
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57672 (2013)
The object of this study was to test whether posaconazole, a broad-spectrum antifungal agent inhibiting ergosterol biosynthesis, exhibits synergy with the β-1,3 glucan synthase inhibitor caspofungin or the calcineurin inhibitor FK506 against the hum
Externí odkaz:
https://doaj.org/article/14dd1a3b9df94fa18f6f0aae40de2b05
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002364 (2011)
Apoptosis is a form of programmed cell death critical for development and homeostasis in multicellular organisms. Apoptosis-like cell death (ALCD) has been described in several fungi, including the opportunistic human pathogen Cryptococcus neoformans
Externí odkaz:
https://doaj.org/article/8a1f97f202024213983bf1bb049f725b
Autor:
Yeseul Choi, Eunji Jeong, Dong-Gi Lee, Jae-Hyung Jin, Yee-Seul So, Seong-Ryong Yu, Kyung-Jo Lee, Yoonjie Ha, Chi-Jan Lin, Ying-Lien Chen, Jun Bae Park, Hyun-Soo Cho, Anna F. Averette, Joseph Heitman, Kyu-Ho Lee, Kangseok Lee, Yong-Sun Bahn
Publikováno v:
mBio. 13
The cellular function and structural configuration of the KEOPS complex have been elucidated in some eukaryotes and archaea but have never been fully characterized in fungal pathogens. Here, we comprehensively analyzed the pathobiological roles of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea2dbabe83777347596ab6086000c0e
https://doi.org/10.1128/mbio.02944-22
https://doi.org/10.1128/mbio.02944-22
Autor:
Kyung-Tae Lee, Kwang Woo Jung, Yelin Lee, Dongpil Lee, Seong Ryong Yu, Anna F. Averette, Kyung Jin Seo, Yu Byeong Jang, Myung Ha Lee, Yong Sun Bahn, Yee Seul So, Sun-Woo Kim, Hyun Ah Kang, Eun Ha Jang, Jae Hyung Jin, Jin Young Kim, Eunji Cheong, Jaeyoung Choi, Jin Tae Choi, Yong-Hwan Lee, Seung Heon Lee, Dong-Gi Lee, Yeonseon Lee, Yeseul Choi, Eunji Jeong, Joohyeon Hong, Jae Won La, Minjae Lee, Eun Jung Thak, Haneul Choi, Joseph Heitman, Ji Seok Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Phosphatases, together with kinases and transcription factors, are key components in cellular signalling networks. Here, we present a systematic functional analysis of the phosphatases in Cryptococcus neoformans, a fungal pathogen that causes life-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340feee0b9c95826a904bc3989e5910d
http://link.springer.com/article/10.1038/s41467-020-18028-0
http://link.springer.com/article/10.1038/s41467-020-18028-0
Autor:
Anna F. Averette, Sheng Sun, Alexandria Scott, Debra Murray, Joseph Heitman, Paul M. Magwene, Ci Fu, Cullen Roth
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009313 (2021)
PLoS Genetics
PLoS Genetics
Cryptococcal disease is estimated to affect nearly a quarter of a million people annually. Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical infections in temperate climates such as Europe, vary in their pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679c913c1dd4302b51c0d76d5c69c22b
https://doi.org/10.1101/2020.08.21.259861
https://doi.org/10.1101/2020.08.21.259861
Autor:
Anna F. Averette, Yong Sun Bahn, Kwang Woo Jung, Michael J. Hoy, Jeffrey I. Everitt, Kyung-Tae Lee, Joseph Heitman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the pathogenicity of Cryptococcus neoformans; however, its role remains unknown i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7c89febb6fceea2ef9fee1c90ad23b
http://link.springer.com/article/10.1038/s41598-018-26405-5
http://link.springer.com/article/10.1038/s41598-018-26405-5
Autor:
Sophie M. C. Gobeil, Leonard D. Spicer, David A. Fox, Jackie J. Lin, Maria Ciofani, William J. Steinbach, Michael J. Hoy, Praveen R. Juvvadi, Ronald A. Venters, Blake C. Barrington, Zanetta Chang, Maria A. Schumacher, Anna F. Averette, Joseph Heitman, Michael Trzoss, Mitchell Mutz, Ying-Lien Chen, Joshua D. Wheaton, Xiaoming Li, Soo Chan Lee, Benjamin G. Bobay, D. Christopher Cole
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e25dca73de3347142bc94a3eb686547
https://doi.org/10.1038/s41467-019-12199-1
https://doi.org/10.1038/s41467-019-12199-1
Autor:
Seyedmojtaba Seyedmousavi, Christina A. Cuomo, Anna F. Averette, Sheng Sun, Aylin Döğen, Çağrı Ergin, Joseph Heitman, Mustafa Şengül, Levent Aksoy, Macit Ilkit
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Cryptococcusspecies are life-threatening human fungal pathogens that cause cryptococcal meningoencephalitis in both immunocompromised and healthy hosts. The natural environmental niches ofCryptococcusinclude pigeon (Columba livia) guano, soil, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dfdf9f500b7fce5e53e260751a0d47