Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Anna Elisabetta Salcini"'
Autor:
Abigail R. R. Guillermo, Karolina Chocian, Gavriil Gavriilidis, Julien Vandamme, Anna Elisabetta Salcini, Jane Mellor, Alison Woollard
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Evidence of global heterochromatin decay and aberrant gene expression in models of physiological and premature ageing have long supported the “heterochromatin loss theory of ageing”, which proposes that ageing is aetiologicall
Externí odkaz:
https://doaj.org/article/194508ad184f48f08a8ab0577b076117
Autor:
Sung-Hak Kim, Kaushal Joshi, Ravesanker Ezhilarasan, Toshia R. Myers, Jason Siu, Chunyu Gu, Mariko Nakano-Okuno, David Taylor, Mutsuko Minata, Erik P. Sulman, Jeongwu Lee, Krishna P.L. Bhat, Anna Elisabetta Salcini, Ichiro Nakano
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 226-238 (2015)
Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstr
Externí odkaz:
https://doaj.org/article/1c457d4e45ce4752aab063e5f575bffd
Autor:
Pier Giorgio Amendola, Nico Zaghet, João J Ramalho, Jens Vilstrup Johansen, Mike Boxem, Anna Elisabetta Salcini
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006632 (2017)
The eukaryotic genome is organized in a three-dimensional structure called chromatin, constituted by DNA and associated proteins, the majority of which are histones. Post-translational modifications of histone proteins greatly influence chromatin str
Externí odkaz:
https://doaj.org/article/dec1e584303348998b67da7d69394f79
Autor:
Hanako Tsushima, Maria Grazia Malabarba, Stefano Confalonieri, Francesca Senic-Matuglia, Lisette G G C Verhoef, Cristina Bartocci, Giovanni D'Ario, Andrea Cocito, Pier Paolo Di Fiore, Anna Elisabetta Salcini
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56383 (2013)
Protein interaction modules coordinate the connections within and the activity of intracellular signaling networks. The Eps15 Homology (EH) module, a protein-protein interaction domain that is a key feature of the EH-network, was originally identifie
Externí odkaz:
https://doaj.org/article/41ce5f0d3eef4c9687e7c0574a3f8d52
Autor:
Julien Vandamme, Gaëlle Lettier, Simone Sidoli, Elia Di Schiavi, Ole Nørregaard Jensen, Anna Elisabetta Salcini
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002647 (2012)
Epigenetic modifications influence gene expression and provide a unique mechanism for fine-tuning cellular differentiation and development in multicellular organisms. Here we report on the biological functions of UTX-1, the Caenorhabditis elegans hom
Externí odkaz:
https://doaj.org/article/d652d9a45ee6437db4e0340c62bd7ce9
Autor:
Anna Elisabetta Salcini, Karolina Chocian, Alison Woollard, Gavriil Gavriilidis, Jane Mellor, Abigail R R Guillermo, Julien Vandamme
Publikováno v:
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Guillermo, A R R, Chocian, K, Gavriilidis, G, Vandamme, J, Salcini, A E, Mellor, J & Woollard, A 2021, ' H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner ', BMC Biology, vol. 19, no. 1, 59, pp. 1-17 . https://doi.org/10.1186/s12915-021-00984-8
BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Guillermo, A R R, Chocian, K, Gavriilidis, G, Vandamme, J, Salcini, A E, Mellor, J & Woollard, A 2021, ' H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner ', BMC Biology, vol. 19, no. 1, 59, pp. 1-17 . https://doi.org/10.1186/s12915-021-00984-8
Background Evidence of global heterochromatin decay and aberrant gene expression in models of physiological and premature ageing have long supported the “heterochromatin loss theory of ageing”, which proposes that ageing is aetiologically linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5364106777191dfe9bb60bef649bc30c
http://europepmc.org/articles/PMC7995591
http://europepmc.org/articles/PMC7995591
Publikováno v:
Development.
Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators of H3K4 methylation are causally associated with neurodevelopmental disorders ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d4dcb82c96c9d8dbc7cc3d3a7fd830
https://doi.org/10.1242/dev.190637
https://doi.org/10.1242/dev.190637
Autor:
Anna Elisabetta Salcini, Federico Rossi, Samuel Demharter, Konstantin Khodosevich, Nico Zaghet, Pier Giorgio Amendola, Katrine Dragsbæk Madsen, Daniel Fernandez Perez, Diego Pasini, Ulrich Pfisterer
Publikováno v:
Cell Reports
Zaghet, N, Madsen, K, Rossi, F, Perez, D F, Amendola, P G, Demharter, S, Pfisterer, U, Khodosevich, K, Pasini, D & Salcini, A E 2021, ' Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality ', Cell Reports, vol. 37, no. 8, pp. 110050 . https://doi.org/10.1016/j.celrep.2021.110050
Zaghet, N, Madsen, K, Rossi, F, Perez, D F, Amendola, P G, Demharter, S, Pfisterer, U, Khodosevich, K, Pasini, D & Salcini, A E 2021, ' Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality ', Cell Reports, vol. 37, no. 8, pp. 110050 . https://doi.org/10.1016/j.celrep.2021.110050
Summary Germ cells have evolved unique mechanisms to ensure the transmission of genetically and nongenetically encoded information, whose alteration compromises germ cell immortality. Chromatin factors play fundamental roles in these mechanisms. H3K3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6af5601818f3d3b652b567fa4f9fd81
https://doi.org/10.1016/j.celrep.2021.110050
https://doi.org/10.1016/j.celrep.2021.110050
Publikováno v:
Scientific Reports
Myers, T R, Amendola, P G, Lussi, Y C & Salcini, A E 2018, ' JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress ', Scientific Reports, vol. 8, 3765, pp. 1-11 . https://doi.org/10.1038/s41598-018-21914-9
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Myers, T R, Amendola, P G, Lussi, Y C & Salcini, A E 2018, ' JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress ', Scientific Reports, vol. 8, 3765, pp. 1-11 . https://doi.org/10.1038/s41598-018-21914-9
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Post-translational modifications of histones, constitutive components of chromatin, regulate chromatin compaction and control all DNA-based cellular processes. C. elegans JMJD-1.2, a member of the KDM7 family, is a demethylase active towards several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a47f9dea6a8644de2c0183101ec365e
https://doi.org/10.1038/s41598-018-21914-9
https://doi.org/10.1038/s41598-018-21914-9
Autor:
Ole N. Jensen, Carsten Friis, Jesper Christensen, Julien Vandamme, Kristian Helin, Luca Mariani, Anna Elisabetta Salcini, Simone Sidoli
Publikováno v:
Nucleic Acids Research
Vandamme, J, Sidoli, S, Mariani, L, Friis, C, Christensen, J, Helin, K, Jensen, O N & Salcini, A E 2015, ' H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans ', Nucleic Acids Research, vol. 43, no. 20, pp. 9694-9710 . https://doi.org/10.1093/nar/gkv1063
Vandamme, J, Sidoli, S, Mariani, L, Friis, C, Christensen, J, Helin, K, Jensen, O N & Salcini, A E 2015, ' H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans ', Nucleic Acids Research, vol. 43, no. 20, pp. 9694-9710 . https://doi.org/10.1093/nar/gkv1063
Genome-wide analyses in Caenorhabditis elegans show that post-translational modifications (PTMs) of histones are evolutionary conserved and distributed along functionally distinct genomic domains. However, a global profile of PTMs and their co-occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537b00ac875f447ff878fe92ce779958
http://europepmc.org/articles/PMC4787770
http://europepmc.org/articles/PMC4787770