Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anna E. Thoren"'
Autor:
Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A. Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E. Thoren, Rune Enger
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal fluid (CSF) enters the brain in perivascular spaces of arteries, crosses the ast
Externí odkaz:
https://doaj.org/article/c6ed337b10814edb97b010d6843271db
Autor:
Martine Eilert-Olsen, Rune Enger, Erlend A. Nagelhus, Anna E. Thoren, Vidar Jensen, Wannan Tang, Jarand Berg Hjukse, Klas H. Pettersen
Publikováno v:
Glia. 67:2399-2409
Astrocytic endfeet cover the brain surface and form a sheath around the cerebral vasculature. An emerging concept is that endfeet control blood–brain water transport and drainage of interstitial fluid and waste along paravascular pathways. Little i
Autor:
Knut Sindre Åbjørsbråten, D. Marelius, Ole Petter Ottersen, Leif Østergaard, Luca Bordoni, Rune Enger, Erlend A. Nagelhus, Anna E. Thoren, Sebastian Frische
Publikováno v:
The FASEB Journal. 33
Introduction During brain edema (BE), elevated intracranial pressure (ICP) compresses capillaries and reduces cerebral blood flow (CBF) by decreasing perfusion pressure. The reduction in CBF and th...
Autor:
Christian Brekken, Olav Haraldseth, Ole Petter Ottersen, Ursula Sonnewald, Anna E. Thoren, Erlend A. Nagelhus, Tina Pavlin, Asta Håberg, Elvar M. Eyjolfsson
Publikováno v:
Neurochemical Research
The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent diffusion magnetic resonanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00814ca88ca502105d4923d117c2ed3a
http://hdl.handle.net/11250/2465669
http://hdl.handle.net/11250/2465669
Autor:
Ole Petter Ottersen, Vidar Jensen, Gry Fluge Vindedal, Michael J. Holtzman, Arne Klungland, Anna E. Thoren, Erlend A. Nagelhus, Yong Zhang
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content was increased in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de079c309297bc75d26fa47c05af6706
https://europepmc.org/articles/PMC5157926/
https://europepmc.org/articles/PMC5157926/
Autor:
Eystein Hellstrøm Hoddevik, Rune Enger, Marvin E. Adams, Øivind Skare, Georg Andreas Gundersen, Nadia Nabil Haj-Yasein, Erlend A. Nagelhus, Finn Mogens Haug, Anna E. Thoren, Martine Eilert-Olsen, Pétur Henry Petersen, Gry Fluge Vindedal, Stanley C. Froehner, John M. Burkhardt
Publikováno v:
Glia. 60:432-440
Expression of the water channel aquaporin-4 (AQP4) at the blood-brain interface is dependent upon the dystrophin associated protein complex. Here we investigated whether deletion of the Aqp4 gene affects the molecular composition of this protein scaf
Autor:
Øivind Skare, Anna E. Thoren, Georg Andreas Gundersen, Ole Petter Ottersen, John M. Burkhardt, Erlend A. Nagelhus, Petter Laake, Arne Klungland, Nadia Nabil Haj-Yasein, Gry Fluge Vindedal, Martine Eilert-Olsen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:17815-17820
Tissue- and cell-specific deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout mouse line was generated to resolve whether astroglial AQP4 controls w
Publikováno v:
Journal of Neurochemistry. 97:968-978
To provide insights into the effects of temporary focal ischemia on the function of neurons and astrocytes in vivo, we measured the incorporation of radiolabel from [U-14C]glucose into both glutamate and glutamine in brain subregions at 1 h of reperf
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 25:440-450
Stroke is one of the leading causes of disability and death. Most often, stroke results from blockage of an artery in the brain leading to tissue infarction within the perfusion territory of the affected vessel. Despite the severity of the insult, ma
Autor:
Marita Broberg, Neil R. Sims, Michael Nilsson, Andrei V. Medvedev, Anna E Thoren, John O. Willoughby, Lorraine Mackenzie
Publikováno v:
Journal of Neuroscience Research. 74:160-166
A role for astroglia in epileptogenesis has been hypothesised but is not established. Low doses of fluorocitrate specifically and reversibly disrupt astroglial metabolism by blocking aconitase, an enzyme integral to the tricarboxylic acid cycle. We u