Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anna E. Sexton"'
Autor:
Erick T Tjhin, Christina Spry, Alan L Sewell, Annabelle Hoegl, Leanne Barnard, Anna E Sexton, Ghizal Siddiqui, Vanessa M Howieson, Alexander G Maier, Darren J Creek, Erick Strauss, Rodolfo Marquez, Karine Auclair, Kevin J Saliba
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006918 (2018)
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antipl
Externí odkaz:
https://doaj.org/article/ca8d6cb2b36a471fb52aa4413da7d352
Autor:
Ghizal Siddiqui, Amanda De Paoli, Christopher A MacRaild, Anna E Sexton, Coralie Boulet, Anup D Shah, Mitchell B Batty, Ralf B Schittenhelm, Teresa G Carvalho, Darren J Creek
Publikováno v:
GigaScience. 11
Background Plasmodium falciparum causes the majority of malaria mortality worldwide, and the disease occurs during the asexual red blood cell (RBC) stage of infection. In the absence of an effective and available vaccine, and with increasing drug res
Publikováno v:
ACS Infectious Diseases. 5:1269-1278
Plasmodium species are evolutionarily distant from model eukaryotes, and as a consequence they exhibit many non-canonical cellular processes. In the post-genomic era, functional "omics" disciplines (transcriptomics, proteomics, and metabolomics) have
Autor:
Leanne Barnard, Anna E. Sexton, Kevin J. Saliba, Darren J. Creek, Alan L. Sewell, Erick Strauss, Annabelle Hoegl, Rodolfo Marquez, Erick T. Tjhin, Christina Spry, Alexander G. Maier, Karine Auclair, Ghizal Siddiqui, Vanessa M. Howieson
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006918 (2018)
PLoS Pathogens
PLoS Pathogens
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antipl
Autor:
Erick Strauss, Leanne Barnard, Kevin J. Saliba, Anna E. Sexton, Vanessa M. Howieson, Karine Auclair, Darren J. Creek, Alan L. Sewell, Erick T. Tjhin, Alexander G. Maier, Annabelle Hoegl, Rodolfo Marquez, Christina Spry
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae9f6761cb01c062f2503a4a874c4d1
Publikováno v:
Journal of proteome research. 16(4)
A detailed analysis of the metabolic state of human-stem-cell-derived erythrocytes allowed us to characterize the existence of active metabolic pathways in younger reticulocytes and compare them to mature erythrocytes. Using high-resolution LC-MS-bas
Autor:
Evelyn S. Chou, Thomas S. Rask, Gerry Tonkin-Hill, Krishanthi Subramaniam, Sabia Z. Abidi, Johanna P. Daily, Michael F. Duffy, Darren J. Creek, Karen P. Day, Aleksandra Leliwa-Sytek, Anna E. Sexton, Marian Teye, Simon A. Cobbold
Publikováno v:
The FEBS journal. 285(5)
Transient regulation of Plasmodium numbers below the density that induces fever has been observed in chronic malaria infections in humans. This species transcending control cannot be explained by immunity alone. Using an in vitro system we have obser
Publikováno v:
Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2057647e87b30ba85adbf1afa7faac68
https://doi.org/10.1002/9783527694082.ch14
https://doi.org/10.1002/9783527694082.ch14
Autor:
Lorena T. Davies, Richard J. Rebello, Bernard L. Flynn, Darren J. Creek, Victoria L. Oliver, Anna E. Sexton, Luc Furic, Luigi Aurelio, Melissa R. Pitman, Stuart M. Pitson, Carmen V. Scullino
The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in biological investigations of the role of SK1 and SK2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo. However, interpretations of resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed3c60cc13882b12d40903c5860d89
https://hdl.handle.net/11541.2/117671
https://hdl.handle.net/11541.2/117671
Autor:
Anna E. Sexton, Aleksandra Wesełucha-Birczyńska, Darren J. Creek, Bayden R. Wood, Mateusz Kozicki, Belinda Joan Morahan
Publikováno v:
The Analyst. 140(7)
Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) and Raman spectroscopy were used to compare chloroquine (CQ)-treated and untreated cultured Plasmodium falciparum-infected human red blood cells (iRBCs). The studies were carried out i