High Plasma Levels of Soluble Lectin‐like Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity

Autor: Sara E. Stinson, Anna E. Jonsson, Mette K. Andersen, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Yun Huang, Evelina Stankevič, Helene Bæk Juel, Lars Ängquist, Thorkild I. A. Sørensen, Emily L. Ongstad, Ranjitha Gaddipati, Joseph Grimsby, Christopher J. Rhodes, Oluf Pedersen, Michael Christiansen, Jens‐Christian Holm, Torben Hansen

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023)

Background Lectin‐like oxidized low‐density lipoprotein (ox‐LDL) receptor‐1 is a scavenger receptor for oxidized low‐density lipoprotein. In adults, higher soluble lectin‐like ox‐LDL receptor‐1 (sLOX‐1) levels are associated with ca

Externí odkaz: https://doaj.org/article/f8e2b7bde0c84cd1a9abf38ec9a67ea9

Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures

Autor: Julie R. Lundgren, Kristine Færch, Daniel R. Witte, Anna E. Jonsson, Oluf Pedersen, Torben Hansen, Torsten Lauritzen, Jens J. Holst, Dorte Vistisen, Marit E. Jørgensen, Signe S. Torekov, Nanna B. Johansen

Publikováno v: Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-9 (2019)

Abstract Background and aim Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with decreases in b

Externí odkaz: https://doaj.org/article/2414a8a9200545269eced300e7a98d3d

Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists

Autor: Mahesh M Umapathysivam, Elisa Araldi, Benoit Hastoy, Adem Y Dawed, Hasan Vatandaslar, Shahana Sengupta, Adrian Kaufmann, Søren Thomsen, Bolette Hartmann, Anna E Jonsson, Hasan Kabakci, Swaraj Thaman, Niels Grarup, Christian T Have, Kristine Færch, Anette P Gjesing, Sameena Nawaz, Jane Cheeseman, Matthew J Neville, Oluf Pedersen, Mark Walker, Christopher Jennison, Andrew T Hattersley, Torben Hansen, Fredrik Karpe, Jens J Holst, Angus G Jones, Michael Ristow, Mark I McCarthy, Ewan R Pearson, Markus Stoffel, Anna L Gloyn

Patients with type 2 diabetes vary in their response to currently available therapeutic agents (including GLP-1 receptor agonists) leading to suboptimal glycemic control and increased risk of complications. We show that human carriers of hypomorphic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::157451176660a0e343840228d18dc298
https://doi.org/10.1101/2023.04.07.23288197

The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

Autor: Sophia Metz, Nikolaj T Krarup, Thomas Bryrup, Julie Støy, Ehm A Andersson, Christina Christoffersen, Matt J Neville, Malene R Christiansen, Anna E Jonsson, Daniel R Witte, Ulla Kampmann, Lars B Nielsen, Niklas R Jørgensen, Fredrik Karpe, Niels Grarup, Oluf Pedersen, Tuomas O Kilpeläinen, Torben Hansen

Publikováno v: Metz, S, Krarup, N T, Bryrup, T, Støy, J, Andersson, E A, Christoffersen, C, Neville, M J, Christiansen, M R, Jonsson, A E, Witte, D R, Kampmann, U, Nielsen, L B, Jørgensen, N R, Karpe, F, Grarup, N, Pedersen, O, Kilpeläinen, T O & Hansen, T 2022, ' The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism ', Journal of the Endocrine Society, vol. 6, no. 5, bvac034 . https://doi.org/10.1210/jendso/bvac034

Context Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG, is associated with lower fasting co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e71937d7907ffdd3d8d2570d4f554b
https://doi.org/10.1210/jendso/bvac034