Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis

Autor: Melania Minoia, Jany Quintana-Cordero, Katharina Jetzinger, Ilgin Eser Kotan, Kathryn Jane Turnbull, Michela Ciccarelli, Anna E. Masser, Dorina Liebers, Eloïse Gouarin, Marius Czech, Vasili Hauryliuk, Bernd Bukau, Günter Kramer, Claes Andréasson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we discover a dedicated ribosome-associated chaperone, Chp1, that rewires the cotranslational folding machinery to

Externí odkaz: https://doaj.org/article/f23814c7fcb4463299135165d37e841c

Genetic inactivation of essentialHSF1reveals an isolated transcriptional stress response selectively induced by protein misfolding

Autor: Michela Ciccarelli, Anna E. Masser, Jayasankar Mohanakrishnan Kaimal, Jordi Planells, Claes Andréasson

Heat Shock Factor 1 (Hsf1) in yeast drives the basal transcription of key proteostasis factors and its activity is induced as part of the core heat shock response. Exploring Hsf1 specific functions has been challenging due to the essential nature of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82e0d2c13682b91088461b43706b009c
https://doi.org/10.1101/2023.05.05.539545

Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products

Autor: Matthias M. Knopp, Nikolai K. Kiil-Nielsen, Anna E. Masser, Mikael Staaf

Publikováno v: Separations; Volume 9; Issue 2; Pages: 52
Knopp, M M, Kiil-Nielsen, N K, Masser, A E & Staaf, M 2022, ' Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products ', Separations, vol. 9, no. 2, 52 . https://doi.org/10.3390/separations9020052

The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance. As no standardized method is available for this purpose, this study sought to develop a biorelevant diss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdff3484807b509b8e4708352b98eb8b

Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast

Autor: Jayasankar Mohanakrishnan Kaimal, Marc R. Friedländer, Anna E. Masser, Claes Andréasson, Wenjing Kang, Naveen Kumar Chandappa Gowda

Publikováno v: Molecular Biology of the Cell

Yeast Hsp70 nucleotide exchange factor Fes1 is expressed by rare alternative splicing as two isoforms. Fes1L is targeted to the nucleus, and Fes1S localizes to the cytosol and is required for the efficient proteasomal degradation of cytosolic misfold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9200140d149e14c6889b81c75b9cb
https://doi.org/10.1091/mbc.e15-10-0697

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

Autor: Matevž Ambrožič, Hannah Dawitz, Jayasankar Mohanakrishnan Kaimal, Markus L. Björck, Claes Andréasson, Peter Brzezinski, Anna E. Masser, Thomas Nyström, Sabrina Büttner, Agata Smialowska, Tamara Suhm, Sarah Hanzén, Carlotta Peselj, Martin Ott

Publikováno v: Cell metabolism. 27(6)

Cellular proteostasis is maintained via the coordinated synthesis, maintenance, and breakdown of proteins in the cytosol and organelles. While biogenesis of the mitochondrial membrane complexes that execute oxidative phosphorylation depends on cytopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55340001a70f26a70db87b5c265f7ab6
https://pubmed.ncbi.nlm.nih.gov/29754951