Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna E Lobley"'
Autor:
Stefano Pirrò, Anna E Lobley, Esteban Gea, Alastair Ironside, Jun Wang, Pedro R. Cutillas, Rachel L. Nelan, Emanuela Gadaleta, Pauline Fourgoux, Claude Chelala, Conrad Bessant, Graeme J. Thorn, Louise J. Jones, Vinothini Rajeeve, Nicholas R. Lemoine, Helen Ross-Adams
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. However, up to 40% of women develop local r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd0d729c539ba94c8f027e45c33e8e4
https://doi.org/10.1038/s41523-020-00182-9
https://doi.org/10.1038/s41523-020-00182-9
Publikováno v:
Nucleic Acids Research
One of the challenges of the post-genomic era is to provide accurate function annotations for large volumes of data resulting from genome sequencing projects. Most function prediction servers utilize methods that transfer existing database annotation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dea82d5fb9450036dd1b7d4efce516
http://europepmc.org/articles/PMC2447771
http://europepmc.org/articles/PMC2447771
Autor:
Adam P. Levine, Anthony W. Segal, Gavin W. Sewell, Daniel L. Roden, Anna E. Lobley, Andrew M. Smith
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e81123 (2014)
PLoS ONE
PLoS ONE
Summary Complex human diseases can show significant heterogeneity between patients with the same phenotypic disorder. An outlier detection strategy was developed to identify variants at the level of gene transcription that are of potential biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2195569511fbc52693bdf0847e65df
http://europepmc.org/articles/PMC3885386?pdf=render
http://europepmc.org/articles/PMC3885386?pdf=render
Autor:
Daniel W. A. Buchan, Sean M. Ward, Kevin Bryson, David T. Jones, Anna E. Lobley, Timothy Nugent
Publikováno v:
Nucleic Acids Research
The UCL Bioinformatics Group web portal offers several high quality protein structure prediction and function annotation algorithms including PSIPRED, pGenTHREADER, pDomTHREADER, MEMSAT, MetSite, DISOPRED2, DomPred and FFPred for the prediction of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27c3fc421218b0519eee7299fc341cd
https://eprints.gla.ac.uk/269967/1/269967.pdf
https://eprints.gla.ac.uk/269967/1/269967.pdf
Publikováno v:
Bioinformatics (Oxford, England). 25(14)
Motivation: Generation of structural models and recognition of homologous relationships for unannotated protein sequences are fundamental problems in bioinformatics. Improving the sensitivity and selectivity of methods designed for these two tasks th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93966ffa4f0557ac4630237aeb2285b
https://pubmed.ncbi.nlm.nih.gov/19429599
https://pubmed.ncbi.nlm.nih.gov/19429599
Publikováno v:
Genome Biology
Signals for microRNA targeting and ubiquitination are enriched in intrinsically disordered proteins, but some highly disordered proteins can escape rapid degradation.
Background Disordered proteins need to be expressed to carry out specified fun
Background Disordered proteins need to be expressed to carry out specified fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3b00c7482380779240df2b677844a2
https://doi.org/10.1186/gb-2009-10-5-r50
https://doi.org/10.1186/gb-2009-10-5-r50
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 8, p e162 (2007)
PLoS Computational Biology
PLoS Computational Biology
Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of disordered residues, and not only have many of these regions been confirmed experimentally, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafc47a56cf0cd0f9d3bfe12208b9372
https://doi.org/10.1371/journal.pcbi.0030162
https://doi.org/10.1371/journal.pcbi.0030162