Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Anna Drabczyńska"'
Autor:
Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1079 (2023)
Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B (MAO-B) inhibitors with significant ancillary A2A adenosine receptor (A2AAR)
Externí odkaz:
https://doaj.org/article/a763a392789d4e87855485b3273ec76a
Autor:
Kieć-Kononowicz, Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna
Publikováno v:
Biomolecules; Volume 13; Issue 7; Pages: 1079
Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B (MAO-B) inhibitors with significant ancillary A2A adenosine receptor (A2AAR)
Autor:
Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Karolina Reguła, Marek Bednarski, Małgorzata Zygmunt, Anna Drabczyńska, Jacek Sapa, Katarzyna Kieć-Kononowicz
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0229806 (2020)
The A2 adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence of the selective antagonist of A2A adenosin
Externí odkaz:
https://doaj.org/article/2d0c6a2ccf8848c79ffcb34e1aaa30e1
Autor:
Clara T. Schoeder, Christa E. Müller, Andhika B Mahardhika, Katarzyna Kieć-Kononowicz, Anna Drabczyńska
Publikováno v:
ACS Med Chem Lett
[Image: see text] GPR18 is a rhodopsin-like orphan G-protein-coupled receptor (GPCR) that is activated by the natural cannabinoid (CB) Δ(9)-tetrahydrocannabinol (THC). It is highly expressed in immune cells and represents a promising new drug target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4660877b74b1ccf8f6e58ee943a5b4e
https://ruj.uj.edu.pl/xmlui/handle/item/264543
https://ruj.uj.edu.pl/xmlui/handle/item/264543
Autor:
Małgorzata Zygmunt, Magdalena Kotańska, Karolina Reguła, Katarzyna Kieć-Kononowicz, Anna Drabczyńska, Marek Bednarski, Małgorzata Szafarz, Kamil Mika, Jacek Sapa, Anna Dziubina
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0229806 (2020)
PLoS ONE
PLoS ONE
The A2adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence of the selective antagonist of A2Aadenosine
Autor:
Christa E. Müller, Ewa Szymańska, Agata Doroz-Płonka, Tadeusz Karcz, Michał Załuski, Sonja Hinz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Jakub Schabikowski, Anna Drabczyńska, Katarzyna Stanuch, Gniewomir Latacz
A library of 27 novel amide derivatives of annelated xanthines was designed and synthesized. The new compounds represent 1,3-dipropyl- and 1,3-dibutyl-pyrimido[2,1-f]purinedione-9-ethylphenoxy derivatives including a CH2CONH linker between the (CH2)2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b888a53d1f4b43743bcee14d03925bd2
https://ruj.uj.edu.pl/xmlui/handle/item/143835
https://ruj.uj.edu.pl/xmlui/handle/item/143835
Autor:
Jadwiga Handzlik, Christa E. Müller, Janina Karolak-Wojciechowska, Anna Drabczyńska, Katarzyna Kieć-Kononowicz, Andrzej Fruziński, Jakub Schabikowski, Agata Doroz-Płonka, Meryem Köse, Ewa Szymańska, Tadeusz Karcz
Publikováno v:
Bioorganicmedicinal chemistry. 24(18)
A new series of 32 pyrimido- and 5 tetrahydropyrazino[2,1-f]purinediones was obtained and evaluated for their adenosine receptors (ARs) affinities. The 1,3-dibutyl derivative of 9-(4-(2-(dimethylamino)ethoxy)phenyl)-6,7,8,9-tetrahydropyrimido[1,2-f]p
Autor:
Anna, Dziubina, Karina, Szmyd, Małgorzata, Zygmunt, Jacek, Sapa, Magdalena, Dudek, Barbara, Filipek, Anna, Drabczyńska, Michał, Załuski, Karolina, Pytka, Katarzyna, Kieć-Kononowicz
Publikováno v:
Pharmacological reports : PR. 68(6)
It has recently been suggested that the adenosine AIn the present study, imidazo- and pyrimido[2,1-f]purinedione derivatives (KD 66, KD 167, KD 206) with affinity to AThe results showed the antidepressant-like activity of pyrimido- and imidazopurined
Autor:
Karina Szmyd, Michał Załuski, Katarzyna Kieć-Kononowicz, Anna Drabczyńska, Jacek Sapa, Magdalena Dudek, Barbara Filipek, Karolina Pytka, Małgorzata Zygmunt, Anna Dziubina
Background It has recently been suggested that the adenosine A2A receptor plays a role in several animal models of depression. Additionally, A2A antagonists have reversed behavioral deficits and exhibited a profile similar to classical antidepressant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a2e328fdc91a6b9f4a3ca34044cbc1
https://ruj.uj.edu.pl/xmlui/handle/item/138926
https://ruj.uj.edu.pl/xmlui/handle/item/138926
Autor:
Christa E. Müller, Jacek Sapa, Małgorzata Zygmunt, Katarzyna Kieć-Kononowicz, Barbara Filipek, Anna Drabczyńska
Publikováno v:
Archiv der Pharmazie. 344:20-27
The present work describes the synthesis of a pyrazinopurinedione derivative which was together with a series of pyrimidopurinedione derivatives tested for potential antiparkinsonian activity in two tests: the "oxotremorine" and the "reserpine" test.