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Akademický článek

A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)

Abstract Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of a large number of potential genetic alterations of multiple driver genes

Externí odkaz: https://doaj.org/article/25368c6568c249e3961734d462c71641

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Akademický článek

Personalized First-Line Treatment of Metastatic Pancreatic Neuroendocrine Carcinoma Facilitated by Liquid Biopsy and Computational Decision Support

Autor: Judita Szkukalek, Róbert Dóczi, Anna Dirner, Ákos Boldizsár, Ágnes Varga, Júlia Déri, Dóra Lakatos, Dóra Tihanyi, Barbara Vodicska, Richárd Schwáb, Gábor Pajkos, Edit Várkondi, István Vályi-Nagy, Dorottya Valtinyi, Zsuzsanna Nagy, István Peták

Publikováno v: Diagnostics, Vol 11, Iss 10, p 1850 (2021)

Background: We present the case of a 50-year-old female whose metastatic pancreatic neuroendocrine tumor (pNET) diagnosis was delayed by the COVID-19 pandemic. The patient was in critical condition at the time of diagnosis due to the extensive tumor

Externí odkaz: https://doaj.org/article/7ab3b8fd1ec74cd3a1932c4cb7cb1cdb

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

Publikováno v: World Journal of Pediatrics.

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20a66d3a298ad402de63a2e4fc3c76ec
https://doi.org/10.1007/s12519-023-00700-2

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A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
NPJ Precision Oncology

Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of a large number of potential genetic alterations of multiple driver genes in a comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4f791853a330d4ab5b91c92a495c54
https://doi.org/10.1038/s41698-021-00191-2

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Performance analysis of a novel artificial intelligence-based computational method on published ex vivo drug sensitivity data to support targeted treatment decisions in precision oncology

Autor: Istvan Petak, Barbara Vodicska, Eniko Kispeter, Robert Doczi, Dora Tihanyi, Dora Lakatos, Anna Dirner, Matyas Vidermann, Reka Szalkai-Denes, Dora Mathiasz, Richard Schwab, Istvan T. Valyi-Nagy

Publikováno v: Journal of Clinical Oncology. 40:e13618-e13618

e13618 Background: Comprehensive molecular profiling is readily available for clinical practice. An extensive amount of published evidence provides information about the potential functional relevance of many driver genes and genetic alterations. But

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b29450c6fd973388a97690b51e5a321
https://doi.org/10.1200/jco.2022.40.16_suppl.e13618

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Real-world data on the clinical utility of a novel artificial intelligence-based computational method to support treatment decisions in gastrointestinal cancers

Autor: Istvan Petak, Barbara Vodicska, Eniko Kispeter, Robert Doczi, Dora Tihanyi, Dora Lakatos, Anna Dirner, Matyas Vidermann, Reka Szalkai-Denes, Julia Deri, Maud Kamal, Richard Schwab, Christophe Le Tourneau

Publikováno v: Journal of Clinical Oncology. 40:e13616-e13616

e13616 Background: Several molecularly targeted agents (MTA) are registered in the same indication, even in the same line, to treat gastrointestinal (GI) cancers. Comprehensive molecular profiling is readily available for many patients, but only a fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::574081e9971c21554b949bb5c179deeb
https://doi.org/10.1200/jco.2022.40.16_suppl.e13616

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Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, ALK-Positive, TP53-Mutant NSCLC

Autor: László Urbán, Anna Dirner, Barbara Vodicska, Dóra Lakatos, László Tóth, Edit Várkondi, István Vályi-Nagy, István Takacs, Dora Tihanyi, István Peták, Róbert Dóczi, Dóra Kormos

Publikováno v: Journal of Personalized Medicine, Vol 10, Iss 107, p 107 (2020)
Journal of Personalized Medicine

Background: The anaplastic lymphoma kinase (ALK) gene fusion rearrangement is a potent oncogene, accounting for 2–7% of lung adenocarcinomas, with higher incidence (17–20%) in non-smokers. ALK-positive tumors are sensitive to ALK tyrosine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40e2d7e4a96b97b2f49bb0a43f339bf
https://www.mdpi.com/2075-4426/10/3/107

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Personalized First-Line Treatment of Metastatic Pancreatic Neuroendocrine Carcinoma Facilitated by Liquid Biopsy and Computational Decision Support

Autor: Julia Deri, Róbert Dóczi, Barbara Vodicska, Dora Tihanyi, István Peták, István Vályi-Nagy, Judita Szkukalek, Anna Dirner, Dóra Lakatos, Ákos Boldizsár, Zsuzsanna Nagy, Edit Várkondi, Ágnes Varga, Richard Schwab, Gábor Pajkos, Dorottya Valtinyi

Publikováno v: Diagnostics
Diagnostics, Vol 11, Iss 1850, p 1850 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44402a14e9c8830b5b26976d90f2b9b1
https://doi.org/10.3390/diagnostics11101850

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