Výsledky vyhledávání - "Anna Di Stefano"

In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways

Autor: Lucia Coppo, G. P. Pessina, Domenico Summa, Paolo Di Simplicio, Danila Di Giuseppe, Antonios Margaritis, Carlo Aldinucci, Raffaella Priora, Simona Frosali, Anna Di Stefano

Publikováno v: Pharmacological Research. 64:289-297

Three different NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP) and 3-morpholino-sydnonimine hydrochloride (SIN-1) were used in order to investigate mechanisms of platelet inhibition through cGMP-dependent and -independent pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed69fbbea27d33e06d2051bef19a102
https://doi.org/10.1016/j.phrs.2011.03.014

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Lycopene phytocomplex, but not pure lycopene, is able to trigger apoptosis and improve the efficacy of photodynamic therapy in HL60 human leukemia cells

Autor: Anna Ettorre, Anna Di Stefano, Simona Frosali, Marco Andreassi

Publikováno v: Experimental Biology and Medicine. 235:1114-1125

We compared the ability of pure lycopene (Lyco) versus lycopene phytocomplex (LycoC) to induce apoptosis in vitro. We found that LycoC, but not Lyco, was able to trigger apoptosis in HL60 cells, as documented by subdiploid DNA content and phosphatidy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9518276316e24aac36378707f978d28
https://doi.org/10.1258/ebm.2010.009386

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Psychosine-induced apoptosis and cytokine activation in immune peripheral cells of Krabbe patients

Autor: Carla Battisti, Anna Laura Pasqui, Elena Radi, Pietro Enea Lazzerini, Patrizia Formichi, Franco Laghi-Pasini, Anna Di Stefano, Antonio Federico, G. Pompella, Alessandra Leonini

Publikováno v: Journal of Cellular Physiology. 212:737-743

Globoid cell leukodystrophy or Krabbe disease (KD), is a hereditary disorder caused by galactosylceramidase deficiency. Progressive accumulation of psychosine is considered to be the critical pathogenetic mechanism of cell death in the Krabbe brain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7ac6f35fff27842272bd8f0cf1e325
https://doi.org/10.1002/jcp.21070

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GSH depletion, protein S-glutathionylation and mitochondrial transmembrane potential hyperpolarization are early events in initiation of cell death induced by a mixture of isothiazolinones in HL60 cells

Autor: Anna Di Stefano, Francesca Cherubini Di Simplicio, Simona Frosali, Anna Ettorre, Paolo Di Simplicio, Alessandra Leonini, Raffaella Priora

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763(2):214-225

We recently described that brief exposure of HL60 cells to a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-methyl-4-isothiazolin-3-one (MI) induces apoptosis at low concentrations (0.001-0.01%) and necrosis at higher concentrations (0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc501e486e5401b83597867ae8d4a8ea

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Biochemical and Biological Aspects of Protein Thiolation in Cells and Plasma

Autor: Raffaella Priora, Paolo Di Simplicio, Francesca Cherubini Di Simplicio, Anna Di Stefano, Domenico Summa, Simona Frosali, Danila Di Giuseppe

Publikováno v: Antioxidants & Redox Signaling. 7:951-963

Protein thiolation is elicited by oxidation by different mechanisms and is involved in a variety of biological processes. Thiols, protein SH (PSH) and non-protein SH groups (NPSH, namely GSH), are in competition in all biological environments in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efedde1bde9b500208850b4f7aa3d8d2
https://doi.org/10.1089/ars.2005.7.951

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Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells

Autor: Paola Martelli, Rita La Gaetana, Paola Lusini, Anna Di Stefano, Lucia Bovalini

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1314(1-2):105-108

Khellin, a furochromone structurally related to furocoumarins, is a phototherapeutic agent used against psoriasis and vitiligo. This paper reports that pretreatment of HeLa cells with pertussis toxin reverses both the inhibition of NaF-stimulated ade

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The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions

Autor: Antonios Margaritis, Danila Di Giuseppe, Raffaella Priora, Anna Di Stefano, Domenico Summa, Paolo Di Simplicio, Lucia Coppo, Simona Frosali

Publikováno v: Pharmacological research. 63(1)

Blood platelets are central to haemostasis and platelet aggregation is considered to be a direct index of platelet function. Although protein disulfides (PSSP) are structural components of most proteins, current evidence suggests that PSSP work toget

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801aae79086020aa818fe3fa86a52cce
https://pubmed.ncbi.nlm.nih.gov/20883787

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Apoptosis in CADASIL: An in vitro study of lymphocytes and fibroblasts from a cohort of Italian patients

Autor: Anna Di Stefano, Giuseppe Di Maio, Ermelinda Tarquini, Elena Radi, Alessandra Leonini, Maria Teresa Dotti, Patrizia Formichi, Carla Battisti, Antonio Federico

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease affecting vascular smooth muscle cells of nearly all tissues. Clinical manifestations mainly concern the central nervous syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0314e0bb09a22e33ebba5bc224c8ab
http://hdl.handle.net/11365/25602

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