Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancerResearch in context

Autor: Francesca Di Modugno, Anna Di Carlo, Sheila Spada, Belinda Palermo, Lorenzo D'Ambrosio, Daniel D'Andrea, Gaia Morello, Beatrice Belmonte, Isabella Sperduti, Vittoria Balzano, Enzo Gallo, Roberta Melchionna, Mariangela Panetta, Giulia Campo, Francesca De Nicola, Frauke Goeman, Barbara Antoniani, Silvia Carpano, Gianmaria Frigè, Sarah Warren, Filippo Gallina, Diether Lambrechts, Jieyi Xiong, Benjamin G. Vincent, Nathan Wheeler, Dante S. Bortone, Federico Cappuzzo, Francesco Facciolo, Claudio Tripodo, Paolo Visca, Paola Nisticò

Publikováno v: EBioMedicine, Vol 101, Iss , Pp 105003- (2024)

Summary: Background: Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, pro

Externí odkaz: https://doaj.org/article/5fd739eb5c1748ce8a0ed4de3fe1985a

The Nucleolar Protein Nucleophosmin Is Physiologically Secreted by Endothelial Cells in Response to Stress Exerting Proangiogenic Activity Both In Vitro and In Vivo

Autor: Anna Di Carlo, Sara Beji, Silvia Palmerio, Mario Picozza, Marco D’Agostino, Vincenzo Petrozza, Roberta Melchionna, Antonia Germani, Alessandra Magenta, Elena De Falco, Daniele Avitabile

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3672 (2021)

Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for th

Externí odkaz: https://doaj.org/article/2cd1ea70d67b4e6aa382de9648190c59

The Nucleolar Protein Nucleophosmin Is Physiologically Secreted by Endothelial Cells in Response to Stress Exerting Proangiogenic Activity Both In Vitro and In Vivo

Autor: Roberta Melchionna, Mario Picozza, Marco D'Agostino, Sara Beji, Silvia Palmerio, Alessandra Magenta, Antonia Germani, Anna Di Carlo, Daniele Avitabile, Elena De Falco, Vincenzo Petrozza

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3672, p 3672 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7

Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3616fd8cde30911968e9c0c821e615c5
https://www.mdpi.com/1422-0067/22/7/3672

hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis

Autor: Paola Nisticò, Anna Di Benedetto, Irene Terrenato, Anna Di Carlo, Sheila Spada, Mina J. Bissell, Francesca Di Modugno, Barbara Antoniani, Isabella Sperduti, Martin A. Schwartz, Belinda Palermo, Francesco Gandolfi, Francesco Facciolo, Pierluigi Iapicca, Marcella Mottolese, Emily I. Chen, Angela Santoni, Paolo Visca

Publikováno v: Di Modugno, F; Spada, S; Palermo, B; Visca, P; Iapicca, P; Di Carlo, A; et al.(2018). hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis. Oncogene, 37(42), 5605-5617. doi: 10.1038/s41388-018-0364-3. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9vr1p6q1
Oncogene
Di Modugno, F, Spada, S, Palermo, B, Visca, P, Iapicca, P, Di Carlo, A, Antoniani, B, Sperduti, I, Di Benedetto, A, Terrenato, I, Mottolese, M, Gandolfi, F, Facciolo, F, Chen, E I, Schwartz, M A, Santoni, A, Bissell, M J & Nisticò, P 2018, ' hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis ', Oncogene, vol. 37, no. 42, pp. 5605-5617 . https://doi.org/10.1038/s41388-018-0364-3
Oncogene, vol 37, iss 42

We demonstrated previously that the splicing of the actin regulator, hMENA, generates two alternatively expressed isoforms, hMENA11a and hMENAΔv6, which have opposite functions in cell invasiveness. Their mechanisms of action have remained unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d95e4d0de3629709e2c87ca616bcfdd
http://www.escholarship.org/uc/item/9vr1p6q1

Naturally Adipose Stromal Cell-Enriched Fat Graft: Comparative Polychromatic Flow Cytometry Study of Fat Harvested by Barbed or Blunt Multihole Cannula

Autor: Alessio Caggiati, Antonia Germani, Anna Di Carlo, Giovanna Borsellino, Mario Picozza, Maurizio C. Capogrossi

Publikováno v: Aesthetic surgery journal. 37(5)

Background Fat grafts enriched with cells of the stromal vascular fraction (SVF), especially adipose-derived stromal cells (ASCs), exhibit significantly improved retention over non enriched, plain fat. Different types of liposuction cannulae may yiel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f1d09c59d5fa27207bb7c65332c4f1
https://pubmed.ncbi.nlm.nih.gov/28052909