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The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide

Autor: Vincenzo Lo Cascio, Ulisse Garbin, Tatsuya Sawamura, Luciano Cominacini, Anna Rigoni, M. Campagnola, A. M. Pastorino, Anna Fratta Pasini, Anna Davoli

Publikováno v: Journal of Biological Chemistry. 276:13750-13755

Oxidized low density lipoprotein (ox-LDL) has been suggested to affect endothelium-dependent vascular tone through a decreased biological activity of endothelium-derived nitric oxide (NO). Oxidative inactivation of NO is regarded as an important caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dd8352a5ed9dcf3370de6d2b2158d8
https://doi.org/10.1074/jbc.m010612200

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Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-κB through an Increased Production of Intracellular Reactive Oxygen Species

Autor: Luciano Cominacini, Anna Rigoni, Vincenzo Lo Cascio, A. M. Pastorino, Ulisse Garbin, M. Campagnola, Tatsuya Sawamura, Maria L. Tosetti, Anna Fratta Pasini, Anna Davoli

Publikováno v: Journal of Biological Chemistry. 275:12633-12638

In this study we examined the effect of oxidized low density lipoprotein (ox-LDL) on the intracellular production of reactive oxygen species (ROS) in bovine aortic endothelial cells (BAECs) and whether this increase occurs through its binding to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d335cbb66d44daeb8b11f294a75cca
https://doi.org/10.1074/jbc.275.17.12633

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Oxidized low-density lipoprotein increases the production of intracellular reactive oxygen species in endothelial cells

Autor: A. M. Pastorino, G. Gaviraghi, Anna Fratta Pasini, Anna Davoli, Luciano Cominacini, V. Lo Cascio, M. Campagnola, Ulisse Garbin

Publikováno v: Journal of Hypertension. 16:1913-1919

Objective The mechanisms by which oxidized low-density lipoprotein (ox-LDL) induces the expression of adhesion molecules on endothelial cells (HUVECs) are still not clear. The signal transduction pathways for these binding molecules include the trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73db1d1bb5b64c5c9947a9d704f1252d
https://doi.org/10.1097/00004872-199816121-00010

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Lacidipine inhibits the activation of the transcription factor NF-kappa B and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells

Autor: Luciano Cominacini, T. Paulon, A. Fratta Pasini, E. Marchi, Ulisse Garbin, G. Gaviraghi, Anna Davoli, V. Lo Cascio, M. Campagnola, A. M. Pastorino

Publikováno v: Journal of Hypertension. 15:1633-1640

Objective The adhesion of monocytes to endothelium, an early event in atherosclerosis is mediated by cell adhesion molecules. Signal-transduction pathways for these binding molecules include the translocation of the transcription factor NF-κB; moreo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6197bf8db2d581016de272c2e6f53b6c
https://doi.org/10.1097/00004872-199715120-00065

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Predisposition to LDL oxidation during copper-catalyzed oxidative modification and its relation to α-tocopherol content in humans

Autor: B. Cenci, V. Lo Cascio, E. Ratti, A. M. Pastorino, Ulisse Garbin, Luciano Cominacini, C. Pasini, Anna Davoli, G. Gaviraghi

Publikováno v: Clinica Chimica Acta. 204:57-68

The predisposition to LDL oxidation during copper-catalyzed oxidative modification and its relationship with LDL alpha-tocopherol concentration was studied in 41 control subjects. The results show that the predisposition of LDL to oxidation expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4406e9b2e0716d009a194f44677fc26
https://doi.org/10.1016/0009-8981(91)90217-z

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A simple test for predisposition to LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification

Autor: Luciano Cominacini, L A Scuro, Ottavio Bosello, A M Pastorino, G. Gaviraghi, Ulisse Garbin, R. Micciolo, Anna Davoli

Publikováno v: Journal of Lipid Research, Vol 32, Iss 2, Pp 349-358 (1991)
Scopus-Elsevier

When human low density lipoprotein (LDL) obtained from 10 volunteers was incubated in air at 37 degrees C in the presence of various concentrations of copper, an increase in fluorescence was observed with emission maximum at 430 nm when excitation wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd0100727ffa571fe90cb9e6eef644b
http://www.sciencedirect.com/science/article/pii/S0022227520420954

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Comparison of the Effects of a Low-fat, High-carbohydrate Diet at Two Levels of Polyunsaturates on Plasma Lipids of Patients with Familial Endogenous Hypertriglyceridemia

Autor: L. Cominacini, Loredana Brunetti, Ludovico A. Scuro, Ulisse Garbin, Anna Davoli, Ottavio Bosello

Publikováno v: Journal of Nutritional Medicine. 1:95-105

In this study we compared the effects of a low-fat, high-carbohydrate (LFHC) diet at two levels of polyunsaturated fatty acids on plasma lipids of 20 patients affected by familial endogenous hypertriglyceridemia. During the intervention period the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c47522d3ef8ea682660ade0189b3018
https://doi.org/10.3109/13590849009003143

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Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation

Autor: Tatsuya Sawamura, Luciano Cominacini, Chiara Stranieri, Ulisse Garbin, Maria Cristina Nava, Vincenzo Lo Cascio, Anna Fratta Pasini, Anna Davoli

Publikováno v: Journal of hypertension. 23(3)

To obtain further insight into the mechanism underlying the vasodilator effect of nebivolol. Since oxidative inactivation of nitric oxide (NO) is regarded as an important cause of its decreased biological activity, we studied (1) the effect of nebivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4972edfbf3f3868fb3f0932d22b6a29
https://pubmed.ncbi.nlm.nih.gov/15716701

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