Intratumoral administration of the antisecretory peptide AF16 cures murine gliomas and modulates macrophage functions

Autor: Jan Kopecky, Julio Enríquez Pérez, Håkan Eriksson, Edward Visse, Peter Siesjö, Anna Darabi

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Glioblastoma has remained the deadliest primary brain tumor while its current therapy offers only modest survival prolongation. Immunotherapy has failed to record notable benefits in routine glioblastoma treatment. Conventionally, immunother

Externí odkaz: https://doaj.org/article/925b2a31965349c29f03330b8a51108a

Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration

Autor: Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi, Mattias Belting

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)

Abstract Background Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses, such as angiogenesi

Externí odkaz: https://doaj.org/article/139878c7c70b43af97497255555f7499

Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization

Autor: Valeria, Governa, Hugo, Talbot, Kelin, Gonçalves de Oliveira, Myriam, Cerezo-Magaña, Anna, Bång-Rudenstam, Maria C, Johansson, Ann-Sofie, Månsson, Karin, Forsberg-Nilsson, György, Marko-Varga, Julio, Enríquez Pérez, Anna, Darabi, Johan, Malmström, Johan, Bengzon, Charlotte, Welinder, Mattias, Belting

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(9)

Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bd1de3a04763f1161d388c7c5680aef
https://pubmed.ncbi.nlm.nih.gov/35217608

The molecular landscape of ETMR at diagnosis and relapse

Autor: Olaf Witt, Maria Łastowska, Anna Darabi, Ulrich Schüller, Andreas von Deimling, Nada Jabado, Susanne Gröbner, David Sumerauer, Annie Huang, Sebastian M. Waszak, Martin Sill, Xiao-Nan Li, Andrey Korshunov, Julien Masliah-Planchon, Pablo Landgraf, David Ellison, Maria J. Gil-da-Costa, Alexander J.R. Bishop, Christin Schmidt, Pieter Wesseling, Sebastian Brabetz, Marc Remke, July Carolina Romero, Dominique Figarella-Branger, Peter Hauser, Simon Papillon-Cavanagh, Jennifer A. Chan, Felix Sahm, Benjamin Schwalm, Peter Lichter, Ivo Buchhalter, Stephan Wolf, Norman Mack, Matthias A. Karajannis, Till Milde, Jan Koster, Valérie Rigau, Monika Mauermann, Matija Snuderl, Franck Bourdeaut, Christine Haberler, Torsten Pietsch, Volker Hovestadt, Wiesława Grajkowska, Katja von Hoff, Felice Giangaspero, Marcel Kool, Emmanuelle Uro-Coste, Jan O. Korbel, Michael D. Taylor, Martin Hasselblatt, Tobias Rausch, Danny A. Zwijnenburg, Jonas Ecker, Brent A. Orr, David T.W. Jones, Jens Schittenhelm, Aparna Gorthi, Sonja Krausert, Sanda Alexandrescu, Sander Lambo, Jens Martin Hübner, Ben Ho, Stefan M. Pfister, Marina Ryzhova

Publikováno v: Nature
Nature, Nature Publishing Group, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Nature, 576(7786), 274-280. Nature Publishing Group
Lambo, S, Gröbner, S N, Rausch, T, Waszak, S M, Schmidt, C, Gorthi, A, Romero, J C, Mauermann, M, Brabetz, S, Krausert, S, Buchhalter, I, Koster, J, Zwijnenburg, D A, Sill, M, Hübner, J-M, Mack, N, Schwalm, B, Ryzhova, M, Hovestadt, V, Papillon-Cavanagh, S, Chan, J A, Landgraf, P, Ho, B, Milde, T, Witt, O, Ecker, J, Sahm, F, Sumerauer, D, Ellison, D W, Orr, B A, Darabi, A, Haberler, C, Figarella-Branger, D, Wesseling, P, Schittenhelm, J, Remke, M, Taylor, M D, Gil-da-Costa, M J, Łastowska, M, Grajkowska, W, Hasselblatt, M, Hauser, P, Pietsch, T, Uro-Coste, E, Bourdeaut, F, Masliah-Planchon, J, Rigau, V, Alexandrescu, S, Wolf, S, Li, X-N, Schüller, U, Snuderl, M, Karajannis, M A, Giangaspero, F, Jabado, N, von Deimling, A, Jones, D T W, Korbel, J O, von Hoff, K, Lichter, P, Huang, A, Bishop, A J R, Pfister, S M, Korshunov, A & Kool, M 2019, ' The molecular landscape of ETMR at diagnosis and relapse ', Nature, vol. 576, no. 7786, pp. 274-280 . https://doi.org/10.1038/s41586-019-1815-x
Nature, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩

Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a9fb34e854ed244d44bc4f785f2b10
https://hal.archives-ouvertes.fr/hal-02441051

The effect of locally delivered cisplatin is dependent on an intact immune function in an experimental glioma model

Autor: Peter Siesjö, Anna Darabi, Edward Visse, Julio Enríquez Pérez, Sara Fritzell, Jan Kopecky

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)

Several chemotherapeutic drugs are now considered to exert anti-tumour effects, by inducing an immune-promoting inflammatory response. Cisplatin is a potent chemotherapeutic agent used in standard medulloblastoma but not glioblastoma protocols. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0990d022c246f40ead3ff70d59c7c5
https://doi.org/10.1038/s41598-019-42001-7