Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

Autor: Oliver L. Sampson, Cecilia Jay, Emily Adland, Anna Csala, Nicholas Lim, Stella M. Ebbrecht, Lorna C. Gilligan, Angela E. Taylor, Sherley Sherafin George, Stephanie Longet, Lucy C. Jones, Ellie Barnes, John Frater, Paul Klenerman, Susie Dunachie, Miles Carrol, James Hawley, Wiebke Arlt, Andreas Groll, Philip Goulder

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Type I interferon (IFN-I) is an integral part of this early innat

Externí odkaz: https://doaj.org/article/d683836b061e4ba0b5dcbb5c94ffbb54

Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members

Autor: Cecilia Jay, Emily Adland, Anna Csala, Christina Dold, Matthew Edmans, Carl-Philipp Hackstein, Anni Jamsen, Nicholas Lim, Stephanie Longet, Ane Ogbe, Oliver Sampson, Donal Skelly, Owen B. Spiller, Lizzie Stafford, Craig P. Thompson, Lance Turtle, Ellie Barnes, Susanna Dunachie, Miles Carroll, Paul Klenerman, Chris Conlon, Philip Goulder, Lucy C. Jones

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionFamily studies of antiviral immunity provide an opportunity to assess virus-specific immunity in infected and highly exposed individuals, as well as to examine the dynamics of viral infection within families. Transmission of SARS-CoV-2 be

Externí odkaz: https://doaj.org/article/a5c95a05091441acac3048b89bc410c9

Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV

Autor: Reena R. D’Souza, David Bonsall, Philip J. R. Goulder, Vinicius A Vieira, Maximilian Muenchhoff, Cherrelle Dacon, Emily Adland, Anna Csala, Fa’eeda Richards, Pieter Jooste, Nicholas Grayson, M. H. Tsai, Rohin Athavale

Publikováno v: Journal of virology. 96(2)

HIV-specific CD8+ T-cells play a central role in immune control of adult HIV, but their contribution in paediatric infection is less well-characterised. Previously, we identified a group of ART-naive children with persistently undetectable plasma vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8a679951888d42815b285ef368b1f6
https://pubmed.ncbi.nlm.nih.gov/34757843

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection

Autor: Gregory D. Kirk, Marek Radkowski, Anne Edwards, Simon Mallal, Julia G. Prado, Anna Csala, Dimitrios Paraskevis, Persephone Borrow, Emily Adland, Katja Pfafferott, Judith Dalmau, David K. Cole, Philip J. R. Goulder, Nelson L. Michael, Bruce F. Walker, Nora Lavandier, Humberto Valenzuela-Ponce, Beatriz Mothe, Mina John, Justyna D. Kowalska, Pierre Pellegrino, Jacques Fellay, Susan Buchbinder, Søren Buus, Christian Brander, Angelos Hatzakis, Anette Stryhn, Masahiko Mori, Javier Martinez-Picado, Gustavo Reyes Teran, Fabian Chen, Matilda Hill, Gareth Tudor-Williams, Jeffrey N. Martin, Mary Carrington, John Frater, Ian Williams, Santiago Ávila-Ríos, Steve Deeks, Jürgen K. Rockstroh

Publikováno v: Journal of virology, vol 92, iss 4
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Virology
Adland, E, Hill, M, Lavandier, N, Csala, A, Edwards, A, Chen, F, Radkowski, M, Kowalska, J D, Paraskevis, D, Hatzakis, A, Valenzuela-Ponce, H, Pfafferott, K, Williams, I, Pellegrino, P, Borrow, P, Mori, M, Rockstroh, J, Prado, J G, Mothe, B, Dalmau, J, Martinez-Picado, J, Tudor-Williams, G, Frater, J, Stryhn, A, Buus, S, Teran, G R, Mallal, S, John, M, Buchbinder, S, Kirk, G, Martin, J, Michael, N, Fellay, J, Deeks, S, Walker, B, Avila-Rios, S, Cole, D, Brander, C, Carrington, M & Goulder, P 2018, ' Differential immunodominance hierarchy of CD8 + T-cell responses in HLA-B*27 : 05-and-B*27:02-mediated control of HIV-1 infection ', Journal of Virology, vol. 92, no. 4, e01685-17 . https://doi.org/10.1128/JVI.01685-17
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Altres ajuts: This work was funded by grants from the National Institutes of Health (RO1AI46995 to P.G.) and the Wellcome Trust (WT104748MA to P.G.). This project has been funded in whole or in part with federal funds from the Frederick National Labo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409ac90ff36038d811e2e992e7427fec
https://escholarship.org/uc/item/40m4w8kf

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

Autor: Jacob Hurst, Jacquie Flynn, Kuan-Hsiang Gary Huang, Vas Novelli, Luisa Mori, Anna Csala, Bruce D. Walker, Pieter Jooste, Mary Carrington, Thumbi Ndung'u, Philip J. R. Goulder, John Frater, Julia G. Prado, Margaret Clapson, Maximilian Muenchhoff, Leana Laker, Andrew J. Prendergast, Roger L. Shapiro, Paolo Paioni, Vanessa L. Naidoo, Christina F. Thobakgale, Emily Adland

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS Pathogens, Vol 11, Iss 6, p e1004954 (2015)
PLoS Pathogens

HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ecd6ce4ae6f199786941d5ed1b9283
https://ddd.uab.cat/record/163262