IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Autor: Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1. UBE2L3, a ubiqu

Externí odkaz: https://doaj.org/article/660af0374b2c4cafadff2b7f923d181b

Function of the Pseudomonas aeruginosa NrdR Transcription Factor: Global Transcriptomic Analysis and Its Role on Ribonucleotide Reductase Gene Expression.

Autor: Anna Crespo, Lucas Pedraz, Eduard Torrents

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123571 (2015)

Ribonucleotide reductases (RNRs) are a family of sophisticated enzymes responsible for the synthesis of the deoxyribonucleotides (dNTPs), the building blocks for DNA synthesis and repair. Although any living cell must contain one RNR activity to cont

Externí odkaz: https://doaj.org/article/6f9d37aa06f94e969d227988c0422ff9

Aerobic Vitamin B-12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth

Autor: Anna Crespo, Núria Blanco-Cabra, Eduard Torrents

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Pseudomonas aeruginosa is a major pathogenic bacterium in chronic infections and is a model organism for studying biofilms. P. aeruginosa is considered an aerobic bacterium, but in the presence of nitrate, it also grows in anaerobic conditions. Oxyge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8388d936eea55d589a0450f0a04a4ef
http://hdl.handle.net/2445/198521

Regulation of ribonucleotide synthesis by the Pseudomonas aeruginosa two-component system AlgR in response to oxidative stress

Autor: Lucas Pedraz, Eduard Torrents, Anna Crespo, Gabriel Gomila, Marc Van Der Hofstadt

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Dipòsit Digital de la UB
Universidad de Barcelona

Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd8d62a1f651947851edd09ceb40c2e
http://hdl.handle.net/2445/126308

Pseudomonas aeruginosa exhibits deficient biofilm formation in the absence of class II and III ribonucleotide reductases due to hindered anaerobic growth

Autor: Lucas Pedraz, Anna Crespo, Eduard Torrents, Josep Astola

Publikováno v: Frontiers in Microbiology, Vol 7 (2016)
Frontiers in Microbiology

Chronic lung infections by the ubiquitous and extremely adaptable opportunistic pathogen Pseudomonas aeruginosa correlate with the formation of a biofilm, where bacteria grow in association with an extracellular matrix and display a wide range of cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7999da87009569c0949178dda501db0
http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00688/full