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pro vyhledávání: '"Anna Comel"'
Publikováno v:
Cell cycle (Georgetown, Tex.). 14(9)
Intracellular calcium (Ca2+) governs several aspects of the homeostasis of living organisms. The levels of Ca2+ in the cytosol are maintained at a concentration of about 0.1 μM by the continuous action of ATP-powered Ca2+ pumps, which transport Ca2+
Publikováno v:
Mitochondrion.
Mitochondria are sensitive and efficient organelles that regulate essential biological processes including: energy metabolism, decoding and transduction of intracellular signals, and balance between cell death and survival. Of note, dysfunctions in m
The tumor suppressor p53 is a transcription factor that in response to a plethora of stress stimuli activates a complex and context-dependent cellular response ultimately protecting genome integrity. In the last two decades, the discovery of cytoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacef691145f47b10621f4fcf728db82
https://hdl.handle.net/11368/2838834
https://hdl.handle.net/11368/2838834
Autor:
Stefano Gustincich, Giannino Del Sal, Francesca Persichetti, Anna Comel, Fiamma Mantovani, Alice Grison, Elena Agostoni
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the gene coding for huntingtin protein. Several mechanisms have been proposed by which mutant huntingtin (mHtt) may trigger striatal neurodegeneration, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b4ef448bdf114b631db4d39f43bc62
http://hdl.handle.net/20.500.11767/16005
http://hdl.handle.net/20.500.11767/16005
Autor:
Francesca Tocco, Jarno Drost, Anna Comel, Fiamma Mantovani, Giannino Del Sal, Ran Elkon, Jos Jonkers, Ron M. Kerkhoven, Reuven Agami, Henne Holstege, P. Mathijs Voorhoeve
Publikováno v:
Nature Cell Biology
Oncogene-induced senescence is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations and others show a dysfunctional p53 pathway, frequently by unknown mechanisms. Here we identif