Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1

Autor: Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys

Publikováno v: eLife, Vol 12 (2023)

Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,

Externí odkaz: https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

Autor: Mathew Clement, Kristin Ladell, Kelly L. Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V. Kriukova, Ksenia R. Lupyr, Olga V. Britanova, David R. Withers, Simon A. Jones, Dmitriy M. Chudakov, David A. Price, Ian R. Humphreys

Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity, but the mechanisms that underpin the development of such regulatory networks in vivo have remained obscure. To address this knowledge ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76df9b035acfe053f4830024a303462d
https://doi.org/10.1101/2022.01.25.477742

IL-27 - a double agent in the IL-6 family

Autor: Gareth W. Jones, Simon Arnett Jones, Anna Cardus, David Hill

Summary The cytokine interleukin (IL)-6 is a major therapeutic target for the treatment of various inflammatory and autoimmune diseases. While IL-6 receives considerable attention in studies of innate and adaptive immunity, the IL-6-related family me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cfaa6eeacbef0d4d10e534332eeb85

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

Autor: Claire J. Greenhill, C. Pitzalis, Anwen Sian Williams, Anna Cardus, Michele Bombardieri, Gareth W. Jones, Vidalba Rocher-Ros, Simon Arnett Jones, Louise McLeod, Brendan J. Jenkins, Alessandra Nerviani

Publikováno v: Jones, G W, Bombardieri, M, Greenhill, C J, McLeod, L, Nerviani, A, Rocher-Ros, V, Cardus, A, Williams, A S, Pitzalis, C, Jenkins, B J & Jones, S A 2015, ' Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis ', Journal of Experimental Medicine, vol. 212, no. 11, pp. 1793-1802 . https://doi.org/10.1084/jem.20132307

Ectopic lymphoid-like structures (ELSs) reminiscent of secondary lymphoid organs often develop at sites of chronic inflammation where they contribute to immune-mediated pathology. Through evaluation of synovial tissues from rheumatoid arthritis (RA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb315842fb36f70f7aa91e3ad4ac9b6
http://orca.cf.ac.uk/78703/

[Untitled]

Autor: Anna Cardus, Gareth W. Jones, Simon Jones, Jason Peter Twohig

Publikováno v: Cytokine. 70:73

Aims Interleukin-6 (IL-6) plays a pivotal role in essential inflammatory events in both innate and acquired immunity including T cell recruitment, differentiation, activation and survival. This importance is highlighted by the central role of IL-6 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65862018f18cd0fb76ef3813394e554e
https://doi.org/10.1016/j.cyto.2014.07.193