PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

Autor: Majken B. Thomsen, Sara A. Ferreira, Anna C. Schacht, Jan Jacobsen, Mette Simonsen, Cristine Betzer, Poul H. Jensen, David J. Brooks, Anne M. Landau, Marina Romero-Ramos

Publikováno v: Neurobiology of Disease, Vol 149, Iss , Pp 105229- (2021)

Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a major pathological characteristic of Parkinson's disease (PD). These fibrillar structur

Externí odkaz: https://doaj.org/article/e84c90d222694d34bb219e601b025c82

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Autor: Alan F. Hofmann, Mary Erickson, Kristoffer Kjærgaard, Susanne Keiding, David Shapiro, Michael Sørensen, Anna C. Schacht, Ole Lajord Munk, Jacob Horsager, Kim Frisch

Publikováno v: Kjærgaard, K, Frisch, K, Sørensen, M, Munk, O L, Hofmann, A F, Horsager, J, Schacht, A C, Erickson, M, Shapiro, D A & Keiding, S 2021, ' Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis ', Journal of Hepatology, vol. 74, no. 1, pp. 58-65 . https://doi.org/10.1016/j.jhep.2020.07.028

Background & Aims: Obeticholic acid (OCA) is an agonist of the nuclear bile acid receptor farnesoid X receptor, which regulates hepatic bile acid metabolism. We tested whether OCA treatment would influence hepatic transport of conjugated bile acids i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8852637514a0cfe3f5190f789668a8c
https://doi.org/10.1016/j.jhep.2020.07.028

Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs

Autor: Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, Caroline C. Real, Kathrine Stokholm, Majken Borup Thomsen, Hamed Zaer, Dariusz Orlowski, Trine Werenberg Mikkelsen, Andreas N. Glud, Erik Holm Toustrup Nielsen, Anna C. Schacht, Michael Winterdahl, David J. Brooks, Jens Christian H. Sørensen, Anne M. Landau

Publikováno v: Lillethorup, T P, Noer, O, Alstrup, A K O, Real, C C, Stokholm, K, Thomsen, M B, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, A N, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A M 2022, ' Spontaneous Partial Recovery of Striatal Dopaminergic Uptake Despite Nigral Cell Loss in Asymptomatic MPTP-Lesioned Female Minipigs ', NeuroToxicology . https://doi.org/10.1016/j.neuro.2022.05.006
Lillethorup, T P, Noer, O, Alstrup, A K O, Cristiano Real Gregório, C, Stokholm, K, Thomsen, M, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, AN, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A 2022, ' Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs ', NeuroToxicology, vol. 91, pp. 166-176 . https://doi.org/10.1016/j.neuro.2022.05.006

The Göttingen minipig is a large animal with a gyrencephalic brain that expresses complex behaviour, making it an attractive model for Parkinson's disease research. Here, we investigate the temporal evolution of presynaptic dopaminergic function for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32413bc32e32832cc10a8107f5514a0f
https://pubmed.ncbi.nlm.nih.gov/35569565

Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

Autor: Anne M. Landau, Anna C. Schacht, Albert Gjedde, Dariusz Orlowski, Steen Jakobsen, Ove Noer, Aage Kristian Olsen Alstrup, Michael Winterdahl

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Winterdahl, M, Noer, O, Orlowski, D, Schacht, A C, Jakobsen, S, Alstrup, A K O, Gjedde, A & Landau, A M 2019, ' Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain ', Scientific Reports, vol. 9, 16918 . https://doi.org/10.1038/s41598-019-53430-9
Winterdahl, M, Noer, O, Orlowski, D, Schacht, A C, Jakobsen, S, Alstrup, A K O, Gjedde, A & Landau, A 2019, ' Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain ', Scientific Reports, vol. 9, no. 1, 16918 . https://doi.org/10.1038/s41598-019-53430-9
Scientific Reports
Winterdahl, M, Noer, O, Orlowski, D, Schacht, A C, Jakobsen, S, Alstrup, A K O, Gjedde, A & Landau, A M 2019, ' Sucrose intake lowers mu-opioid and dopamine D2/3 receptor availability in porcine brain ', Scientific Reports, vol. 9, 16918 . https://doi.org/10.1038/s41598-019-53430-9

Excessive sucrose consumption elicits addiction-like craving that may underpin the obesity epidemic. Opioids and dopamine mediate the rewarding effects of drugs of abuse, and of natural rewards from stimuli such as palatable food. We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed10ec9a1c59858135d69577207d035
http://link.springer.com/article/10.1038/s41598-019-53430-9

PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

Autor: Marina Romero-Ramos, David J. Brooks, Majken B. Thomsen, Sara A. Ferreira, Poul Henning Jensen, Jan Jacobsen, Cristine Betzer, Mette Kildevæld Simonsen, Anna C. Schacht, Anne M. Landau

Publikováno v: Neurobiology of Disease, Vol 149, Iss, Pp 105229-(2021)
Thomsen, M B, Ferreira, S A, Schacht, A C, Jacobsen, J, Simonsen, M, Betzer, C, Jensen, P H, Brooks, D J, Landau, A M & Romero-Ramos, M 2021, ' PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats ', Neurobiology of Disease, vol. 149, 105229 . https://doi.org/10.1016/j.nbd.2020.105229

Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a major pathological characteristic of Parkinson's disease (PD). These fibrillar structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4836b9ee6da7273d37f7236901f3d4
https://doi.org/10.1016/j.nbd.2020.105229