Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anna C. McCarter"'
Autor:
Ashley F. Melnick, Anna C. McCarter, Shannon Liang, Yiran Liu, Qing Wang, Nicole A. Dean, Elizabeth Choe, Nicholas Kunnath, Geethika Bodanapu, Carea Mullin, Fatema Akter, Karena Lin, Brian Magnuson, Surinder Kumar, David B. Lombard, Andrew G. Muntean, Mats Ljungman, JoAnn Sekiguchi, Russell J.H. Ryan, Mark Y. Chiang
Publikováno v:
bioRxiv
Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic in clinical trials. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4d955aa2343712be55e599923fb0db
https://europepmc.org/articles/PMC9882378/
https://europepmc.org/articles/PMC9882378/
Autor:
Yiran Liu, Cher Sha, Alberto Ambesi-Impiombato, Michael C. Ostrowski, Erin Kim, Theresa M. Keeley, Jahnavi K. Nalamolu, Qing Wang, Mark Y. Chiang, Adolfo A. Ferrando, Ran Yan, Rohan Kodgule, Russell J.H. Ryan, Arvind Rao, Nicholas Kunnath, Linda C. Samuelson, Barbara L. Kee, Giusy Della Gatta, Anna C. McCarter, Rork Kuick, Ashley Melnick, Mengxi Sun
Publikováno v:
Blood Cancer Discov
Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxicities. To circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b842e2f9d5afeb347ec0996b550218
https://doi.org/10.1158/2643-3230.bcd-20-0026
https://doi.org/10.1158/2643-3230.bcd-20-0026
Publikováno v:
Advances in experimental medicine and biology. 1066
Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d4597bc89384090ae5e5556f6c7679e
https://pubmed.ncbi.nlm.nih.gov/30030836
https://pubmed.ncbi.nlm.nih.gov/30030836
Autor:
Yiran Liu, Cher Sha, Qing Wang, Mark Y. Chiang, Tomasz Cierpicki, Nancy Pinnell, Noah F. Garber, Ivy T. Tran, Qingqing Wu, Yitong Chen, Anna C. McCarter, Ivan Maillard, Yeonjoo Oh, Ran Yan, Rork Kuick, Amparo Serna Alarcon, Chia Jui Ku, James Douglas Engel
Publikováno v:
Blood. 132(12)
Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4(−)CD8(−) double-negative (DN) thymocytes and progression to the CD4(+)CD8(+) double-positive (DP) stage through β-selection. During this critical phase of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3347a6c364112f6d9388f50cb0f61d5
https://pubmed.ncbi.nlm.nih.gov/30076146
https://pubmed.ncbi.nlm.nih.gov/30076146
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319895116
Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913a0b537ab171cdb63f978040289929
https://doi.org/10.1007/978-3-319-89512-3_18
https://doi.org/10.1007/978-3-319-89512-3_18
Autor:
Mark Y. Chiang, Yiran Liu, Cher Sha, Rork Kuick, Amparo Serna Alarcon, Michael C. Ostrowski, Erin Kim, Linda C. Samuelson, Qing Wang, Anna C. McCarter, Moshe Talpaz, Russell J.H. Ryan, Catherine Chang, Luke F. Peterson, Ran Yan
Publikováno v:
Blood. 132:2595-2595
The discovery of NOTCH1 as the most frequently mutated oncogene in T-ALL patients raised hopes for targeted therapy in this cancer. Unfortunately, in clinical trials, the pan-Notch inhibitor GSI caused excessive GI toxicity. Mice treated continuously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56bdea79b57fed1bee9fff4acc453b93
https://doi.org/10.1182/blood-2018-99-111376
https://doi.org/10.1182/blood-2018-99-111376
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of t