Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications

Autor: Ho Jung An, Mira A. Partha, HoJoon Lee, Billy T. Lau, Dmitri S. Pavlichin, Alison Almeda, Anna C. Hooker, Giwon Shin, Hanlee P. Ji

Publikováno v: Frontiers in Oncology, Vol 13 (2024)

BackgroundColon microbiome composition contributes to the pathogenesis of colorectal cancer (CRC) and prognosis. We analyzed 16S rRNA sequencing data from tumor samples of patients with metastatic CRC and determined the clinical implications.Material

Externí odkaz: https://doaj.org/article/f36916f7469247408cf94f0de232d4f5

Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies

Autor: Billy T. Lau, Dmitri Pavlichin, Anna C. Hooker, Alison Almeda, Giwon Shin, Jiamin Chen, Malaya K. Sahoo, Chun Hong Huang, Benjamin A. Pinsky, Ho Joon Lee, Hanlee P. Ji

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)

Abstract Background The genome of SARS-CoV-2 is susceptible to mutations during viral replication due to the errors generated by RNA-dependent RNA polymerases. These mutations enable the SARS-CoV-2 to evolve into new strains. Viral quasispecies emerg

Externí odkaz: https://doaj.org/article/6c281c23b3f34308a56ed35fdc580c16

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Stomach Malignancies

Autor: Alison F Almeda, Sue Grimes, HoJoon Lee, Stephanie U Greer, GiWon Shin, Madeline McNamara, Anna C Hooker, Maya Arce, Matthew Kubit, Marie Schauer, Paul Van Hummelen, Cindy Ma, Meredith Mills, Robert J Huang, Joo Ha Hwang, Manuel R Amieva, Summer Han, James M. Ford, Hanlee P. Ji

BackgroundGastric cancer (GC) is a leading cause of global cancer morbidity and mortality. Developing information systems which integrate clinical and genomic data may accelerate discoveries to improve cancer prevention, detection, and treatment. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::027f35db7557f541e0de06d2c42236d4
https://doi.org/10.1101/2022.03.10.22271914

The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing

Autor: Cliff L Wang, Jonathan V Feldstein, Hanlee P. Ji, Alison J. Kriegel, Shawn Levy, Christopher E. Mason, Feng Zhang, Jason Kelly, Junbiao Dai, Doug Schenkel, Ebrahim Afshinnekoo, Yizhi Cai, Anna C Hooker, Jeff Huber, Marc L. Salit, Subhalaxmi Nambi, Matthew MacKay, Nick Haft, George M. Church, Anne L. Wyllie

Publikováno v: Nat Biotechnol
Nature Biotechnology
MacKay, M J, Hooker, A C, Afshinnekoo, E, Salit, M, Kelly, J, Feldstein, J V, Haft, N, Schenkel, D, Nambi, S, Cai, Y, Zhang, F, Church, G, Dai, J, Wang, C L, Levy, S, Huber, J, Ji, H P, Kriegel, A, Wyllie, A L & Mason, C E 2020, ' The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing ', Nature biotechnology, vol. 38, no. 9, pp. 1021-1024 . https://doi.org/10.1038/s41587-020-0655-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e0cbddf807e7f3261bf645d3bab98
https://pubmed.ncbi.nlm.nih.gov/32820257