Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anna C Geraghty"'
Autor:
Nathaniel W. Mabe, Min Huang, Guillermo N. Dalton, Gabriela Alexe, Daniel A. Schaefer, Anna C. Geraghty, Amanda L. Robichaud, Amy S. Conway, Delan Khalid, Marius M. Mader, Julia A. Belk, Kenneth N. Ross, Michal Sheffer, Miles H. Linde, Nghi Ly, Winnie Yao, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine S. Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Publikováno v:
Nature Cancer. 3:976-993
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy. Here, we show that reduced GD2 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c9eabc77d406c8f3cf09781745ec5a
https://doi.org/10.1038/s43018-022-00405-x
https://doi.org/10.1038/s43018-022-00405-x
Autor:
Nathaniel W. Mabe, Min Huang, Daniel A. Schaefer, Guillermo N. Dalton, Giulia Digiovanni, Gabriela Alexe, Anna C. Geraghty, Delan Khalid, Marius M. Mader, Michal Sheffer, Miles H. Linde, Nghi Ly, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Publikováno v:
Cancer Research. 82:PR003-PR003
Epigenetic dysregulation is frequently observed in the disease pathology of pediatric cancers, including neuroblastoma, the most common extracranial solid tumor in pediatric patients. Neuroblastoma tumors co-opt developmentally linked adrenergic or m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec928f4c6631b4249bc07df71e89092e
https://doi.org/10.1158/1538-7445.cancepi22-pr003
https://doi.org/10.1158/1538-7445.cancepi22-pr003
Autor:
Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde, Garry L. Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, John L. Silberstein, Anna C. Geraghty, Allison Banuelos, Molly Thomas Radosevich, Shaurya Dhingra, Sabine Heitzeneder, Aidan Tousley, John Lattin, Peng Xu, Jing Huang, Nicole Nasholm, Andy He, Tracy C. Kuo, Emma R. B. Sangalang, Jaume Pons, Amira Barkal, Rachel E. Brewer, Kristopher D. Marjon, Jose G. Vilches-Moure, Payton L. Marshall, Ricardo Fernandes, Michelle Monje, Jennifer R. Cochran, Poul H. Sorensen, Heike E. Daldrup-Link, Irving L. Weissman, Julien Sage, Ravindra Majeti, Carolyn R. Bertozzi, William A. Weiss, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature medicine, vol 28, iss 2
Nat Med
Nat Med
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximately 40% of patients with neuroblastoma sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aad3910b686c28eafa24813f728551c
https://escholarship.org/uc/item/5nz6n240
https://escholarship.org/uc/item/5nz6n240
Autor:
Anthony Fernández-Castañeda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Belgin Yalçın, Kathryn R. Taylor, Selena Dutton, Lehi Acosta-Alvarez, Lijun Ni, Daniel Contreras-Esquivel, Jeff R. Gehlhausen, Jon Klein, Carolina Lucas, Tianyang Mao, Julio Silva, Mario A. Peña-Hernández, Alexandra Tabachnikova, Takehiro Takahashi, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Marco Hefti, Daniel Perl, Rebecca Folkerth, David Putrino, Avi Nath, Akiko Iwasaki, Michelle Monje
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed of information processing and memory. This long-COVID c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cc0fe8c17e140e7f0cc47e06f89d81
https://pubmed.ncbi.nlm.nih.gov/35043113
https://pubmed.ncbi.nlm.nih.gov/35043113
Autor:
Anna C Geraghty, Sandra E Muroy, Sheng Zhao, George E Bentley, Lance J Kriegsfeld, Daniela Kaufer
Publikováno v:
eLife, Vol 4 (2015)
Whereas it is well established that chronic stress induces female reproductive dysfunction, whether stress negatively impacts fertility and fecundity when applied prior to mating and pregnancy has not been explored. In this study, we show that stress
Externí odkaz:
https://doaj.org/article/a71c4253f7ee49709e6ece96dbd984cc
Autor:
Anthony Fernández-Castañeda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R. O’Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalçın, Kathryn R. Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B. Keough, Lijun Ni, Pamelyn J. Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, Jeff R. Gehlhausen, Jon Klein, Takehiro Takahashi, Julio Silva, Benjamin Israelow, Carolina Lucas, Tianyang Mao, Mario A. Peña-Hernández, Alexandra Tabachnikova, Robert J. Homer, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Hannes Vogel, Marco M. Hefti, Daniel P. Perl, Shane Liddelow, Rebecca Folkerth, David Putrino, Avindra Nath, Akiko Iwasaki, Michelle Monje
Publikováno v:
Cell. 185:2452-2468.e16
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1354a1c99466999fc5d4a3f7d6eef4
https://doi.org/10.1016/j.cell.2022.06.008
https://doi.org/10.1016/j.cell.2022.06.008
Publikováno v:
Developmental neurobiology. 78(2)
Human central nervous system myelin development extends well into the fourth decade of life, and this protracted period underscores the potential for experience to modulate myelination. The concept of myelin plasticity implies adaptability in myelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d6289e6a7dfd909432327e979946639
https://pubmed.ncbi.nlm.nih.gov/28986960
https://pubmed.ncbi.nlm.nih.gov/28986960
Autor:
Aaron R. Friedman, Anna C. Geraghty, Kereshmeh Taravosh-Lahn, Meng-Ko Tsai, Robert M. Sapolsky, Christian Mirescu, Andrea Nicholas, Theo D. Palmer, Daniela Kaufer, David Covarrubias, Darlene D. Francis, David E Pleasure, Amrita Krishnamurthy, Alana T. Wong, Sundari Chetty, Danna Krupik, Elizabeth D. Kirby, Fuzheng Guo
Publikováno v:
Molecular psychiatry
Stress can exert long-lasting changes on the brain that contribute to vulnerability to mental illness, yet mechanisms underlying this long-term vulnerability are not well understood. We hypothesized that stress may alter the production of oligodendro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ffb1d334048973018de90816058476
https://doi.org/10.1038/mp.2013.190
https://doi.org/10.1038/mp.2013.190
Publikováno v:
Frontiers in Endocrinology
Reproductive senescence, the point in time when females cease to show estrous cyclicity, is associated with endocrine changes in the hypothalamus, pituitary, and gonads. However, the mechanisms triggering this transition are not well understood. To g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cba53f5dc5cc43952c31beed3843e7
https://doi.org/10.3389/fendo.2016.00071
https://doi.org/10.3389/fendo.2016.00071
Autor:
Anna C, Geraghty, Daniela, Kaufer
Publikováno v:
Advances in experimental medicine and biology. 872
It is well accepted that stress, measured by increased glucocorticoid secretion, leads to profound reproductive dysfunction. In times of stress, glucocorticoids activate many parts of the fight or flight response, mobilizing energy and enhancing surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b2838b05fc2a9a44b746df3dcf76bdb
https://pubmed.ncbi.nlm.nih.gov/26215998
https://pubmed.ncbi.nlm.nih.gov/26215998