Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Anna C Aschenbrenner"'
Autor:
Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, Barbara Gatto
Publikováno v:
eLife, Vol 11 (2022)
Omics-based technologies are driving major advances in precision medicine, but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chloropiperidines,
Externí odkaz:
https://doaj.org/article/0ad35f19a474450691b8671650825bc3
Autor:
Patrick Neubert, Arne Homann, David Wendelborn, Anna-Lorena Bär, Luka Krampert, Maximilian Trum, Agnes Schröder, Stefan Ebner, Andrea Weichselbaum, Valentin Schatz, Peter Linz, Roland Veelken, Jonas Schulte-Schrepping, Anna C Aschenbrenner, Thomas Quast, Christian Kurts, Sabrina Geisberger, Karl Kunzelmann, Karin Hammer, Katrina J Binger, Jens Titze, Dominik N Müller, Waldemar Kolanus, Joachim L Schultze, Stefan Wagner, Jonathan Jantsch
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000722 (2020)
Inflammation and infection can trigger local tissue Na+ accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (MΦs) and their antimicrobial activity. Enhanced Na+-driven MΦ function requires the
Externí odkaz:
https://doaj.org/article/3249cb09b6b04812ba5cea7c7d2e59d9
Autor:
Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Lisa Holsten, Tatiana Hesse, Alexej Knaus, Yannick Riedel, Matthias Becker, Kristian Händler, Tarek Elmzzahi, Kevin Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Adem Saglam, Thomas Ulas, Anna C. Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim L. Schultze, Hubert Schorle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Synthetic embryo models have arisen as an approach to probe early development in vitro, facilitating the study of difficult to access stages. Here the authors present a simple system for generating embryo-like structures that resemble peri-implantati
Externí odkaz:
https://doaj.org/article/4777dcfcfbcb4d98ae83f5dc3f98bef3
Autor:
Lorenzo Bonaguro, Jonas Schulte-Schrepping, Thomas Ulas, Anna C. Aschenbrenner, Marc Beyer, Joachim L. Schultze
Publikováno v:
Nature immunology 23(10), 1412-1423 (2022). doi:10.1038/s41590-022-01309-9
nature immunology
nature immunology
The immune system is highly complex and distributed throughout an organism, with hundreds to thousands of cell states existing in parallel with diverse molecular pathways interacting in a highly dynamic and coordinated fashion. Although the character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68de29f38d5e16bae4a69d548ae6a3f1
https://doi.org/10.1038/s41590-022-01309-9
https://doi.org/10.1038/s41590-022-01309-9
Autor:
CATERINA CARRARO, Lorenzo Bonaguro, Rachana Srinivasa, Martina van Uelft, Victoria Isakzai, Jonas Schulte-Schrepping, Prerna Gambhir, Heidi Theis, Michael Kraut, Krishnaa T. Mahbubani, Anna C. Aschenbrenner, Ireen König, Eugenio Fava, Hans-Ulrich Fried, Elena De Domenico, Marc D. Beyer, Adem Saglam, Joachim L. Schultze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c75092a529084a86e25249364de28dd
https://doi.org/10.2139/ssrn.4405264
https://doi.org/10.2139/ssrn.4405264
Autor:
Theodore S. Kapellos, Kevin Bassler, Anna C. Aschenbrenner, Wataru Fujii, Joachim L. Schultze
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease’s progression, and in particular, lung mac
Externí odkaz:
https://doaj.org/article/6d497e605f5147ef8ccc44c60f07be38
Publikováno v:
STAR Protocols 4(2), 102193 (2023). doi:10.1016/j.xpro.2023.102193
Variance of gene expression is intrinsic to any given natural population. Here, we present a protocol to analyze this variance using a conditional quasi loss- and gain-of-function approach. The huva (human variation) package takes advantage of popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e4c59f7236b5c2712a49411b48ac06
https://doi.org/10.1016/j.xpro.2023.102193
https://doi.org/10.1016/j.xpro.2023.102193
Autor:
Kevin Baßler, Wataru Fujii, Theodore S. Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D. Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T. Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H. Wadsworth, Travis K. Hughes, Humberto J. Ferreira, Emily Hinkley, Ines H. Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K. Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C. Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J. Theis, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Frontiers in Immunology
Frontiers in immunology 13, 917232 (2022). doi:10.3389/fimmu.2022.917232
Front. Immunol. 13:917232 (2022)
Frontiers in immunology 13, 917232 (2022). doi:10.3389/fimmu.2022.917232
Front. Immunol. 13:917232 (2022)
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83c1e2c5bb2d42a8a09a2c00ce7337e
https://doi.org/10.3389/fimmu.2022.917232
https://doi.org/10.3389/fimmu.2022.917232
Autor:
Thomas Ulas, Kevin Baßler, Dirk Skowasch, Lisa Holsten, Stefanie Warnat-Herresthal, Christoph Thiele, Jan Hasenauer, Theodore S. Kapellos, Carmen Pizarro, Joachim L. Schultze, Rainer Knoll, Anna C. Aschenbrenner, Wataru Fujii, Kristian Händler, Marie Oestreich, Emily R. Hinkley
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 3 (2021)
ERJ Open Research 7(3), 00915-2020 (2021). doi:10.1183/23120541.00915-2020
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 3 (2021)
ERJ Open Research 7(3), 00915-2020 (2021). doi:10.1183/23120541.00915-2020
Background Immune cells play a major role in the pathogenesis of COPD. Changes in the distribution and cellular functions of major immune cells, such as alveolar macrophages (AMs) and neutrophils are well known; however, their transcriptional reprogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7c049420a3ebaffca5fc4ce0842822
https://doi.org/10.1183/23120541.00915-2020
https://doi.org/10.1183/23120541.00915-2020
Autor:
Anna C. Aschenbrenner, Mihai G. Netea, Leo A. B. Joosten, Blandina T. Mmbaga, Vesla Kullaya, Thomas Ulas, Joachim L. Schultze, Collins K. Boahen, Tal Pecht, Quirijn de Mast, André J. A. M. van der Ven, Gibson S. Kibiki, Furaha Lyamuya, Godfrey S. Temba, Vinod Kumar
Publikováno v:
Nature Immunology. Nature Publishing Group
Nature immunology 22(3), 287-300 (2021). doi:10.1038/s41590-021-00867-8
Nature Immunology, 22, 287-300
Nature Immunology, 22, 3, pp. 287-300
Nat Immunol.
Nature immunology 22(3), 287-300 (2021). doi:10.1038/s41590-021-00867-8
Nature Immunology, 22, 287-300
Nature Immunology, 22, 3, pp. 287-300
Nat Immunol.
Sub-Saharan Africa currently experiences an unprecedented wave of urbanization, which has important consequences for health and disease patterns. This study aimed to investigate and integrate the immune and metabolic consequences of rural or urban li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ccd41c9db02254cf9735b1f7351b77
https://doi.org/10.1038/s41590-021-00867-8
https://doi.org/10.1038/s41590-021-00867-8