Výsledky vyhledávání - "Anna C, Simcocks"

Akademický článek

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Autor: Anna C Simcocks, Kayte A Jenkin, Lannie O’Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch, Deanne H Hryciw

Publikováno v: Endocrine Connections, Vol 8, Iss 3, Pp 203-216 (2019)

Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies

Externí odkaz: https://doaj.org/article/ccc1aef53ea04ec6a00a6e7a1e01c9c8

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Akademický článek

The effect of cyanidin-3-O-β-glucoside and peptides extracted from yoghurt on glucose uptake and gene expression in human primary skeletal muscle myotubes from obese and obese diabetic participants

Autor: Min Shi, Lannie O'Keefe, Anna C. Simcocks, Xiao Q. Su, Andrew J. McAinch

Publikováno v: Journal of Functional Foods, Vol 51, Iss , Pp 55-64 (2018)

Incidence of type II diabetes mellitus (T2DM) is rapidly increasing worldwide. This study aimed to investigate whether cyanidin-3-O-β-glucoside (C3G), or peptides with angiotensin converting enzyme (ACE) inhibitory activity, alone or in combination,

Externí odkaz: https://doaj.org/article/8472513f43f24cf2a36d0b3b6344bbdb

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Autor: Lannie, O'Keefe, Teresa, Vu, Anna C, Simcocks, Kayte A, Jenkin, Michael L, Mathai, Deanne H, Hryciw, Dana S, Hutchinson, Andrew J, McAinch

Publikováno v: International journal of molecular sciences. 23(19)

Diet-induced obesity (DIO) reduces fatty acid oxidation in skeletal muscle and decreases circulating levels of adiponectin. Endocannabinoid signaling is overactive in obesity, with some effects abated by antagonism of cannabinoid receptor 1 (CB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98513f2c0c091e4051f329dda23aea62
https://pubmed.ncbi.nlm.nih.gov/36232744

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Treatment of Diet-Induced Obese Rats with CB2 Agonist AM1241 or CB2 Antagonist AM630 Reduces Leptin and Alters Thermogenic mRNA in Adipose Tissue

Autor: Lannie O’Keefe, Teresa Vu, Anna C. Simcocks, Kayte A. Jenkin, Michael L. Mathai, Andrew J. McAinch, Dana S. Hutchinson, Deanne H. Hryciw

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7601

Diet-induced obesity (DIO) is a contributor to co-morbidities, resulting in alterations in hormones, lipids, and low-grade inflammation, with the cannabinoid type 2 receptor (CB2) contributing to the inflammatory response. The effects of modulating C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a754a9f6250e6f24f878f081dcfacbd
https://doi.org/10.3390/ijms24087601

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Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Autor: Andrew J. McAinch, Chrishan S. Samuel, Michael L. Mathai, Deanne H. Hryciw, Anna C. Simcocks, Kayte A. Jenkin, Lannie O'Keefe

Publikováno v: Endocrine Connections, Vol 8, Iss 3, Pp 203-216 (2019)
Endocrine Connections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3152ca13ce36e48fade05303b178164c
https://ec.bioscientifica.com/view/journals/ec/8/3/EC-18-0535.xml

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CB1 Ligand AM251 Induces Weight Loss and Fat Reduction in Addition to Increased Systemic Inflammation in Diet-Induced Obesity

Autor: Lannie O'Keefe, Teresa Vu, Anna C. Simcocks, Kayte A. Jenkin, Michael L. Mathai, Deanne H. Hryciw, Dana S. Hutchinson, Andrew J. McAinch

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11447

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4fe3bf2590bf8f56388fd8e489619
https://doi.org/10.3390/ijms231911447

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The effect of cyanidin-3-O-β-glucoside and peptides extracted from yoghurt on glucose uptake and gene expression in human primary skeletal muscle myotubes from obese and obese diabetic participants

Autor: Andrew J. McAinch, Min Shi, Lannie O'Keefe, Xiao Q. Su, Anna C. Simcocks

Publikováno v: Journal of Functional Foods, Vol 51, Iss, Pp 55-64 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98317dc4abde982d552c7216c9466137
http://www.sciencedirect.com/science/article/pii/S1756464618305309

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The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity

Autor: Lannie O'Keefe, Kayte A. Jenkin, Andrew J. McAinch, Esther Grinfeld, Michael L. Mathai, Deanne H. Hryciw, Lauren M Cornall, Anna C. Simcocks

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5922, p 5922 (2020)
Volume 21
Issue 16

O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the treatment of obesity by targeting energy homeostasis regulation in skeletal muscle. This study aimed to determine the effect of O-1602

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94b418636eed59ca8355c44d3695241
https://doi.org/10.3390/ijms21165922

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G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction

Autor: Gayathri Rajaraman, Dana S. Hutchinson, Anna C. Simcocks, Deanne H. Hryciw, Andrew J. McAinch

Publikováno v: Molecular Nutrition & Food Research. 60:92-102

Endocannabinoids are products of dietary fatty acids that are modulated by an alteration in food intake levels. Overweight and obese individuals have substantially higher circulating levels of the arachidonic acid derived endocannabinoids, anandamide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed41959b0eb072566ce13faa0f421c36
https://doi.org/10.1002/mnfr.201500449

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Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats

Autor: Lannie O'Keefe, Anna C. Simcocks, Michael L. Mathai, Esther Grinfeld, Kayte A. Jenkin, Deanne H. Hryciw, Andrew J. McAinch

Publikováno v: Journal of Endocrinology. 225:113-124

Modulation of the endocannabinoid system as an anti-obesity therapeutic is well established; however, the direct effects of cannabinoid receptor 1 (CB1) antagonism on renal function and structure in a model of diet-induced obesity (DIO) are unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf1597a4853a56ba4856d4b539e6be0
https://doi.org/10.1530/joe-15-0004

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