Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anna Britt Wimmer"'
Autor:
Konrad Brockmeier, Volker A. W. Kreye, Hugo A. Katus, Herbert E. Ulmer, Kezhong Wu, D. Thomas, Christoph A. Karle, Markus Khalil, Johann Kiehn, Michael Koenen, Joerg Zehelein, Wolfgang Schoels, Manuela Licka, Anna Britt Wimmer
Publikováno v:
Biochimica et Biophysica Acta
Romano-Ward syndrome (RWS), the autosomal dominant form of the congenital long QT syndrome, is characterised by prolongation of the cardiac repolarisation process associated with ventricular tachyarrhythmias of the torsades de pointes type. Genetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4d0b0f746404c7196d1c248da555c1
Autor:
Barbara A. Wible, Sven Kathöfer, Johann Kiehn, Dierk Thomas, Eckhard Ficker, Hugo A. Katus, Eberhard P. Scholz, Christoph A. Karle, Bettina C. Hammerling, Glenn E. Kirsch, Volker A. W. Kreye, Anna-Britt Wimmer, Mary C. Kochan, Edgar Zitron, Kezhong Wu, Wolfgang Schoels
Publikováno v:
British Journal of Pharmacology. 142:485-494
1 The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolonga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15770883fbb943ee88f4e82836dfdb1f
https://doi.org/10.1038/sj.bjp.0705795
https://doi.org/10.1038/sj.bjp.0705795
Autor:
Christoph A. Karle, Kezhong Wu, Dierk Thomas, Eckhard Ficker, Wolfgang Schoels, Anna Britt Wimmer, Yuri A. Kuryshev, Hugo A. Katus, Bettina C. Hammerling, Johann Kiehn
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 369:462-472
Human ether-a-go-go-related gene (HERG) potassium channels are expressed in multiple tissues including the heart and adenocarcinomas. In cardiomyocytes, HERG encodes the alpha-subunit underlying the rapid component of the delayed rectifier potassium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93b27afd8568f906b8ed70a44441568
https://doi.org/10.1007/s00210-004-0931-8
https://doi.org/10.1007/s00210-004-0931-8
Autor:
Johann Kiehn, Dierk Thomas, Christoph A. Karle, Wei Zhang, Wolfgang Schoels, Sven Kathöfer, Kezhong Wu, Hugo A. Katus, Edgar Zitron, Volker A. W. Kreye, Anna Britt Wimmer
Publikováno v:
British Journal of Pharmacology. 140:996-1002
Dronedarone is a noniodinated benzofuran derivative that has been synthesized to overcome the limiting iodine-associated adverse effects of the potent antiarrhythmic drug amiodarone. In this study, the acute electrophysiological effects of dronedaron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2128579fa4d9ab6dd23b7eddfe070b39
https://doi.org/10.1038/sj.bjp.0705502
https://doi.org/10.1038/sj.bjp.0705502
Autor:
Johann Kiehn, Gunnar Wendt-Nordahl, Wei Zhang, Kezhong Wu, Hugo A. Katus, Christoph A. Karle, Sven Kathöfer, Anna-Britt Wimmer, Bernd Gut, Dierk Thomas, Volker A. W. Kreye, Wolfgang Schoels
Publikováno v:
Cardiovascular Research. 59:14-26
Objective: Patients with HERG-associated long QT syndrome typically develop tachyarrhythmias during physical or emotional stress. Previous studies have revealed that activation of the beta-adrenergic system and consecutive elevation of the intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c402a0c1dd2ad19f050e25edbdc1c84f
https://doi.org/10.1016/s0008-6363(03)00386-9
https://doi.org/10.1016/s0008-6363(03)00386-9
Autor:
Hugo A. Katus, Herbert E. Ulmer, Dierk Thomas, Michael Koenen, Manuela Licka, Christoph A. Karle, Anna-Britt Wimmer, Markus Khalil, Jörg Zehelein, Markus Alter, Patrick A. Schweizer
Publikováno v:
Journal of Molecular and Cellular Cardiology (London)
Hereditary long QT syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on the surface ECG and a high risk for arrhythmia-related sudden death. Mutations in a cardiac voltage-gated potassium channel, KCNQ1, ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d486d8dfd0632be3a41e3e213716db32
https://pubmed.ncbi.nlm.nih.gov/19540844
https://pubmed.ncbi.nlm.nih.gov/19540844
Autor:
Joerg Zehelein, Hugo A. Katus, Michael Koenen, Manuela Licka, Christoph A. Karle, Anna-Britt Wimmer, Markus Khalil, Wolfgang Schoels, Dierk Thomas, Johann Kiehn, Herbert E. Ulmer, Markus Alter, Sven Kathöfer
Publikováno v:
Cardiovascular Research
OBJECTIVE: Hereditary long QT syndrome (LQTS) is a genetically heterogeneous disease characterized by prolonged QT intervals and an increased risk for ventricular arrhythmias and sudden cardiac death. Mutations in the voltage-gated potassium channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5db6dc8aff0b0b2617c19f9fc0ce3b
https://hdl.handle.net/11858/00-001M-0000-002A-E5C4-C11858/00-001M-0000-002A-E5C6-8
https://hdl.handle.net/11858/00-001M-0000-002A-E5C4-C11858/00-001M-0000-002A-E5C6-8
Autor:
Hugo A. Katus, Johann Kiehn, Bettina C. Hammerling, Anna-Britt Wimmer, Dierk Thomas, Volker A. W. Kreye, Sven Kathöfer, Wolfgang Schoels, Ramona Bloehs, Christoph A. Karle, Sonja Lueck, Kezhong Wu, Edgar Zitron
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 82(12)
Patients with cardiac disease typically develop life-threatening ventricular arrhythmias during physical or emotional stress, suggesting a link between adrenergic stimulation and regulation of the cardiac action potential. Human ether-a-go-go related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01f046af7cc430e467c097ec2096a69
https://pubmed.ncbi.nlm.nih.gov/15365637
https://pubmed.ncbi.nlm.nih.gov/15365637
Autor:
Yuri A. Kuryshev, Dierk Thomas, Daniel Scherer, Bettina C. Hammerling, Eckhard Ficker, Wolfgang Schoels, Hugo A. Katus, Christoph A. Karle, Anna Britt Wimmer, Kezhong Wu, Johann Kiehn
Publikováno v:
Cardiovascular research. 64(3)
Objective: The human ether-a-go-go-related gene (hERG) encodes the rapid component of the cardiac repolarizing delayed rectifier potassium current, IKr. The direct interaction of the commonly used protein kinase C (PKC) inhibitor bisindolylmaleimide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d9d34a5c4e124a26b85ce6b616f05a
https://pubmed.ncbi.nlm.nih.gov/15537500
https://pubmed.ncbi.nlm.nih.gov/15537500
Autor:
Dierk, Thomas, Sven, Kathofer, Wei, Zhang, Kezhong, Wu, Anna-Britt, Wimmer, Edgar, Zitron, Volker A W, Kreye, Hugo A, Katus, Wolfgang, Schoels, Christoph A, Karle, Johann, Kiehn
Publikováno v:
British journal of pharmacology. 140(5)
Dronedarone is a noniodinated benzofuran derivative that has been synthesized to overcome the limiting iodine-associated adverse effects of the potent antiarrhythmic drug amiodarone. In this study, the acute electrophysiological effects of dronedaron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e061e87c07d26d873b62e4f6690a2ca
https://pubmed.ncbi.nlm.nih.gov/14517175
https://pubmed.ncbi.nlm.nih.gov/14517175