Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anna Brichkina"'
Autor:
Gulnaz Sharapova, Sirina Sabirova, Marina Gomzikova, Anna Brichkina, Nick A Barlev, Natalia V Kalacheva, Albert Rizvanov, Nikita Markov, Hans-Uwe Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7038 (2024)
The metabolism of glioma cells exhibits significant heterogeneity and is partially responsible for treatment outcomes. Given this variability, we hypothesized that the effectiveness of treatments targeting various metabolic pathways depends on the bi
Externí odkaz:
https://doaj.org/article/f9df743188854f1bbbc7f12170980c13
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/7e1f900e4a0f4af8aee7ba1090beabf3
Autor:
Anke Koeniger, Pierfrancesco Polo, Anna Brichkina, Florian Finkernagel, Alexander Visekruna, Andrea Nist, Thorsten Stiewe, Michael Daude, Wibke E Diederich, Thomas M Gress, Till Adhikary, Matthias Lauth
Publikováno v:
NAR Cancer. 5
Transcriptional cancer subtypes which correlate with traits such as tumor growth, drug sensitivity or the chances of relapse and metastasis, have been described for several malignancies. The core regulatory circuits (CRCs) defining these subtypes are
Publikováno v:
Cancers. 15:2614
Pancreatic cancer represents one of the most desmoplastic malignancies and is characterized by an extensive deposition of extracellular matrix. The latter is provided by activated cancer-associated fibroblasts (CAFs), which are abundant cells in the
Autor:
Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Felix Neuhaus, Teresa Ruckenbrod, Anna Hupfer, Hartmann Raifer, Matthias Klein, Tobias Bopp, Petra Ina Pfefferle, Rajkumar Savai, Immo Prinz, Ari Waisman, Sonja Moos, Hyun-Dong Chang, Stefan Heinrich, Detlef K Bartsch, Malte Buchholz, Shiv Singh, Mengyu Tu, Lukas Klein, Christian Bauer, Robert Liefke, Andreas Burchert, Ho-Ryun Chung, Philipp Mayer, Thomas M Gress, Matthias Lauth, Matthias Gaida, Magdalena Huber
Publikováno v:
Gut. :gutjnl-2022
ObjectivePancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and interspersed immune cells. A non-canonical CD8+T-cell subpopulation producing IL-17A (Tc17) promo
Autor:
Matthias Lauth, Anna Hupfer, Petra Ina Pfefferle, Axel Pagenstecher, Frederik Helmprobst, Carsten Denkert, Anna Brichkina, Anke Koeniger, Corinna U Keber, Alexander Visekruna
Publikováno v:
Proc Natl Acad Sci U S A
Increased stiffness of solid tissues has long been recognized as a diagnostic feature of several pathologies, most notably malignant diseases. In fact, it is now well established that elevated tissue rigidity enhances disease progression and aggressi
Autor:
Anna Brichkina, Matthias Lauth, Ekaterina Ivanova, Axel Pagenstecher, Shrey Dharamvir Sharma, Petra Ina Pfefferle, Ursula Keber
Publikováno v:
Biochemical and biophysical research communications. 567
Neuroblastoma (NB), a pediatric cancer of the peripheral sympathetic nervous system, represents the most frequent solid malignancy in infants. Treatment of high-risk patients is still challenging and, depending on the genetic make-up and involved ris
Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
Autor:
Iris Nee, Ilya Galperin, Thorsten Stiewe, Matthias Lauth, Anke Koeniger, Lukas Dempwolff, Till Adhikary, Anna Brichkina, Wibke E. Diederich, Anna Hupfer, Andrea Nist, Florian Finkernagel
Publikováno v:
Cancers
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Simple Summary Elevated GLI1 expression levels are associated with improved survival in NB patients and GLI1 overexpression exerts tumor-suppressive traits in cultured NB cells. However, NB cells are protected from increased GLI1 levels as they have
Publikováno v:
Biochemical and biophysical research communications. 553
Medulloblastoma (MB) is the most common malignant brain tumor in children. Transcriptional profiling has so far delineated four major MB subgroups of which one is driven by uncontrolled Hedgehog (Hh) signaling (SHH-MB). This pathway is amenable to dr
Autor:
A.M. Brzozowska, Timofei S. Zatsepin, Hooi Hong Lau, Hui Mun Loh, Mitali Kakran, Avanee Ketkar, Anna Brichkina, Daria B. Trushina, Tatiana O. Abakumova, Marina V. Novoselova, Maria N. Antipina, Dmitry A. Gorin
Publikováno v:
ACS applied materialsinterfaces. 12(5)
Formulated forms of cancer therapeutics enhance the efficacy of treatment by more precise targeting, increased bioavailability of drugs, and an aptitude of some delivery systems to overcome multiple drug resistance of tumors. Drug carriers acquire im