Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Anna Bianchi-Smiraglia"'
Autor:
Jeffrey C. Martin, Tatiane da Silva Fernandes, Kanita A. Chaudhry, Masanori Oshi, Scott I. Abrams, Kazuaki Takabe, Spencer R. Rosario, Anna Bianchi-Smiraglia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer. Despite decades of intense investigation, treatment options remain limited, and rapid recurrence with distant metastases remains a significant challenge. Can
Externí odkaz:
https://doaj.org/article/a7c14905d0a540b290c52c0f37711b58
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is widely recognized to play important, but complex, modulatory roles in a variety of tumor types. In this review, we comprehensively summarize the increasingly contr
Externí odkaz:
https://doaj.org/article/f2a136bad3de4515a815dfb694395487
Autor:
Kanita A. Chaudhry, Justine J. Jacobi, Bryan M. Gillard, Ellen Karasik, Jeffrey C. Martin, Tatiane da Silva Fernandes, Edward Hurley, Maria Laura Feltri, Kristopher M. Attwood, Clare J. Twist, Dominic J. Smiraglia, Mark D. Long, Anna Bianchi-Smiraglia
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108303- (2023)
Summary: Neuroblastoma is the most common extracranial solid tumor in children. MYCN amplification is detected in almost half of high-risk cases and is associated with poorly differentiated tumors, poor patient prognosis and poor response to therapy,
Externí odkaz:
https://doaj.org/article/0f7c74a86b7e44b09089d3f48142cad7
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Changes in intracellular GTP levels are not considered as a regulatory event in RAC1 activation in live cells since total GTP levels are substantially higher than the RAC1 GTP dissociation constant determined in vitro. Here, the authors demonstrate t
Externí odkaz:
https://doaj.org/article/8aee079d643942f4a47c971818bffc85
Autor:
Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero, Dominic J. Smiraglia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP s
Externí odkaz:
https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce5
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/09f7fc50b96d4098b94d7fd143a62297
Autor:
Archis Bagati, Anna Bianchi-Smiraglia, Sudha Moparthy, Kateryna Kolesnikova, Emily E. Fink, Brittany C. Lipchick, Masha Kolesnikova, Peter Jowdy, Anthony Polechetti, Amin Mahpour, Jason Ross, Joseph A. Wawrzyniak, Dong Hyun Yun, Gyorgy Paragh, Nadezhda I. Kozlova, Albert E. Berman, Jianmin Wang, Song Liu, Michael J. Nemeth, Mikhail A. Nikiforov
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2820-2832 (2017)
Lineage-specific regulation of tumor progression by the same transcription factor is understudied. We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression. Moreover, in contrast to c
Externí odkaz:
https://doaj.org/article/7133add646a249d7b65232fbf92f8021
Autor:
Emily E. Fink, Sudha Moparthy, Archis Bagati, Anna Bianchi-Smiraglia, Brittany C. Lipchick, David W. Wolff, Matthew V. Roll, Jianmin Wang, Song Liu, Andrei V. Bakin, Eugene S. Kandel, Ann-Hwee Lee, Mikhail A. Nikiforov
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 212-223.e4 (2018)
Summary: Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. He
Externí odkaz:
https://doaj.org/article/841b33867763433eac7653bce6e3839f
Autor:
Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Wiam Bshara, Sudha Mannava, Jeff Ackroyd, Archis Bagati, Angela R. Omilian, Michael Im, Natalia Fedtsova, Jeffrey C. Miecznikowski, Kalyana C. Moparthy, Shoshanna N. Zucker, Qianqian Zhu, Nadezhda I. Kozlova, Albert E. Berman, Keith S. Hoek, Andrei V. Gudkov, Donna S. Shewach, Carl D. Morrison, Mikhail A. Nikiforov
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 493-507 (2013)
Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in
Externí odkaz:
https://doaj.org/article/778f0726387c4d02b68bac1250ad63c9
Autor:
Amit A Lugade, Anna Bianchi-Smiraglia, Vandana Pradhan, Galina Elkin, Timothy F Murphy, Yasmin Thanavala
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19781 (2011)
The cross-talk between the innate and the adaptive immune system is facilitated by the initial interaction of antigen with dendritic cells. As DCs express a large array of TLRs, evidence has accumulated that engagement of these molecules contributes
Externí odkaz:
https://doaj.org/article/09afa13a783a498893b7258e41420d33