Supplementary Materials and Methods from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Autor: Roger R. Gomis, Angel R. Nebreda, Eduard Batlle, Cristina Figueras-Puig, Mireia Cartanà, Maria Clapés, Ivan Burkov, Esther Fernandez, Adrià Cañellas, Marc Guiu, Antoni Berenguer-Llergo, Anna Bellmunt, Alicia Llorente, María Teresa Blasco, Jelena Urosevic

Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21db5e948ca710c92a496db9d1fb538b
https://doi.org/10.1158/0008-5472.22427221

ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Autor: Antoni Berenguer-Llergo, Marc Guiu, Mireia Cartanà, Adrià Cañellas, María Teresa Blasco, Eduard Batlle, Maria Clapés, Alicia Llorente, Roger R. Gomis, Anna Bellmunt, Jelena Urosevic, Esther Fernández, Ivan Burkov, Angel R. Nebreda, Cristina Figueras-Puig

Publikováno v: Cancer Research. 80:4668-4680

Carcinoma development in colorectal cancer is driven by genetic alterations in numerous signaling pathways. Alterations in the RAS-ERK1/2 pathway are associated with the shortest overall survival for patients after diagnosis of colorectal cancer meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b4ad3ab66638ab8ceced17b9d8d39
https://doi.org/10.1158/0008-5472.can-19-4028

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Autor: Marc Guiu, Konstantin Slobodnyuk, Roger R. Gomis, Anna Arnal-Estapé, Cristina Saura, Violeta Serra, Sylwia Gawrzak, Enrique J. Arenas, Ivan del Barco Barrantes, Rianne Groeneveld, Aleix Prat, Marta Palafox, Salvador Aznar Benitah, Anna Bellmunt, Juan Miguel Cejalvo, Ana Lluch, Sara Gregorio, Antonio Berenguer-Llergo, Joaquín Arribas, Ana Rovira, Javier Cortes, Daniela Kalafatovic, Cristina Figueras-Puig, Jelena Urosevic, Angel R. Nebreda, Barbara Müllauer, Camille Stephan-Otto Attolini, Esther Fernández, Fernando Salvador, Lorenzo Rinaldi, Montse Muñoz, Federico Rojo, Joan Albanell, Aikaterini Symeonidi

Publikováno v: NATURE CELL BIOLOGY
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

For many patients with breast cancer, symptomatic bone metastases appear after years of latency. How micrometastatic lesions remain dormant and undetectable before initiating colonization is unclear. Here, we describe a mechanism involved in bone met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d570aadc265a8d445db300315f3c62fa
https://doi.org/10.1038/s41556-017-0021-z

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Autor: Patricia Zúñiga-García, Jason W. Locasale, Marc Guiu, M. Unda-Urzaiz, Mireia Castillo-Martin, Rosa Barrio, Amaia Zabala-Letona, Antonio Berenguer, Verónica Torrano, Alfredo Caro-Maldonado, Mar Lorente, Carlos Cordon-Cardo, Roger R. Gomis, Nieves Embade, Ana Loizaga-Iriarte, Victoria Sanz-Moreno, Ana R. Cortazar, Guillermo Velasco, Giampaolo Morciano, James D. Sutherland, Anna Bellmunt, Natalia Martín-Martín, Arkaitz Carracedo, Laura Bozal-Basterra, Aitziber Ugalde-Olano, Xiaojing Liu, Sonia Fernández-Ruiz, Amaia Arruabarrena-Aristorena, Lorea Valcarcel-Jimenez, Pilar Sanchez-Mosquera, Jelena Urosevic, Isabel Lacasa-Viscasillas, Paolo Pinton, Nikolaus Schultz, Mariona Graupera, Pahini Pandya, Ana M. Aransay

Publikováno v: Nature cell biology
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Cell Biology
Dipòsit Digital de la UB
Universidad de Barcelona
Torrano, V, Valcarcel-Jimenez, L, Cortazar, A R, Liu, X, Urosevic, J, Castillo-Martin, M, Fernández-Ruiz, S, Morciano, G, Caro-Maldonado, A, Guiu, M, Zúñiga-García, P, Graupera, M, Bellmunt, A, Pandya, P, Lorente, M, Martín-Martín, N, David Sutherland, J, Sanchez-Mosquera, P, Bozal-Basterra, L, Zabala-Letona, A, Arruabarrena-Aristorena, A, Berenguer, A, Embade, N, Ugalde-Olano, A, Lacasa-Viscasillas, I, Loizaga-Iriarte, A, Unda-Urzaiz, M, Schultz, N, Aransay, A M, Sanz-Moreno, V, Barrio, R, Velasco, G, Pinton, P, Cordon-Cardo, C, Locasale, J W, Gomis, R R & Carracedo, A 2016, ' The metabolic co-regulator PGC1α suppresses prostate cancer metastasis ', Nature Cell Biology, vol. 18, no. 6, pp. 645-656 . https://doi.org/10.1038/ncb3357
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34f0e9d7610f954a76c2ba87f82ad29
http://europepmc.org/articles/PMC4884178

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER

Autor: Sylwia, Gawrzak, Lorenzo, Rinaldi, Sara, Gregorio, Enrique J, Arenas, Fernando, Salvador, Jelena, Urosevic, Cristina, Figueras-Puig, Federico, Rojo, Ivan, Del Barco Barrantes, Juan Miguel, Cejalvo, Marta, Palafox, Marc, Guiu, Antonio, Berenguer-Llergo, Aikaterini, Symeonidi, Anna, Bellmunt, Daniela, Kalafatovic, Anna, Arnal-Estapé, Esther, Fernández, Barbara, Müllauer, Rianne, Groeneveld, Konstantin, Slobodnyuk, Camille, Stephan-Otto Attolini, Cristina, Saura, Joaquín, Arribas, Javier, Cortes, Ana, Rovira, Montse, Muñoz, Ana, Lluch, Violeta, Serra, Joan, Albanell, Aleix, Prat, Angel R, Nebreda, Salvador Aznar, Benitah, Roger R, Gomis

Publikováno v: Nature cell biology. 20(2)

For many patients with breast cancer, symptomatic bone metastases appear after years of latency. How micrometastatic lesions remain dormant and undetectable before initiating colonization is unclear. Here, we describe a mechanism involved in bone met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::076ae6f1ce8b049d0ae55e34d2cedce6
https://pubmed.ncbi.nlm.nih.gov/29674681