Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anna Baulies"'
Autor:
Anna Baulies, Joan Montero, Nuria Matías, Naroa Insausti, Oihana Terrones, Gorka Basañez, Carmen Vallejo, Laura Conde de La Rosa, Laura Martinez, David Robles, Albert Morales, Joaquin Abian, Montserrat Carrascal, Keigo Machida, Dinesh B.U. Kumar, Hidekazu Tsukamoto, Neil Kaplowitz, Carmen Garcia-Ruiz, José C. Fernández-Checa
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 164-177 (2018)
Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) permeabilization. Hepatocellular mt-cholesterol loading, however, promotes ste
Externí odkaz:
https://doaj.org/article/0ee1cf48437d4bc48e440ce37a0d5845
Autor:
Sandra Torres, Nuria Matías, Anna Baulies, Susana Nuñez, Cristina Alarcon-Vila, Laura Martinez, Natalia Nuño, Anna Fernandez, Joan Caballeria, Thierry Levade, Alba Gonzalez-Franquesa, Pablo Garcia-Rovés, Elisa Balboa, Silvana Zanlungo, Gemma Fabrías, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C. Fernández-Checa
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 60-72 (2017)
Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death. While the primary biochemical featu
Externí odkaz:
https://doaj.org/article/2f56652c5022467eb14c86c368ed286a
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underl
Externí odkaz:
https://doaj.org/article/a3b0914b5b7e4dd0a50cba5954cfd289
Publikováno v:
Stem Cells International, Vol 2017 (2017)
The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewa
Externí odkaz:
https://doaj.org/article/e301cc4ad6d742b7b1ca4c44b340fb17
Autor:
Laura Novellasdemunt, Anna Kucharska, Anna Baulies, Colin Hutton, Georgios Vlachogiannis, Dimitra Repana, Andrew Rowan, A. Suárez-Bonnet, Francesca Ciccarelli, Nicola Valeri, Vivian S.W. Li
Publikováno v:
Stem Cell Reports. 18:570-584
Autor:
Laura Novellasdemunt, Anna Kucharska, Anna Baulies, Georgios Vlachogiannis, Dimitra Repana, Andrew Rowan, A Suárez-Bonnet, Francesca Ciccarelli, Nicola Valeri, Vivian S. W. Li
Truncating mutation of the tumor suppressor gene adenomatous polyposis coli (APC) is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d647c99316aff54124cd57f069ea1d
https://doi.org/10.1101/2022.09.22.508986
https://doi.org/10.1101/2022.09.22.508986
Autor:
Carmen García-Ruiz, Susana Nuñez, Carmen G. Vallejo, Maria J. Monte, Juan Carlos García-Valdecasas, Josep Fuster, Vicent Ribas, Joana Ferrer, Anna Baulies, Michael Karin, Fernando Civeira, Lucía Baila-Rueda, Jose J.G. Marin, Laura Conde de la Rosa, Ana Cenarro, José C. Fernández-Checa
Publikováno v:
Journal of hepatology, vol 74, iss 6
Digital.CSIC. Repositorio Institucional del CSIC
instname
Hepatobiliary Surg Nutr
Digital.CSIC. Repositorio Institucional del CSIC
instname
Hepatobiliary Surg Nutr
Background & Aims Besides their physiological role in bile formation and fat digestion, bile acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that modulate hepatocellular carcinoma (HCC). Trafficking of cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f31bf7f148b908fb92597233bae932
https://escholarship.org/uc/item/15v896ht
https://escholarship.org/uc/item/15v896ht
Autor:
Rachel A. Ridgway, Barry J. Thompson, Anna Kucharska, Owen J. Sansom, Julia B. Cordero, Nikolaos Angelis, Clara M. Sidor, Pedro Antas, Vivian S. W. Li, Melissa R Rose, Oriane Guillermin, Anna Baulies
Publikováno v:
The EMBO Journal
Wnt signalling induces a gradient of stem/progenitor cell proliferation along the crypt‐villus axis of the intestine, which becomes expanded during intestinal regeneration or tumour formation. The YAP transcriptional co‐activator is known to be r
Publikováno v:
Development (Cambridge, England). 147(15)
Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development and regene
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
Autor:
Helmuth Gehart, Anna Kucharska, Pedro Antas, Jelte van der Vaart, Vivian S. W. Li, Anna Baulies, Cara Jamieson, Maria Prange‐Barczynska, Madelon M. Maurice, Laura Novellasdemunt
Publikováno v:
The EMBO Journal
The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self‐renewal by inducing RSPO r