Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna Backmark"'
Autor:
Dipankar Bhattacharya, Christine Becker, Benjamin Readhead, Nicolas Goossens, Jacqueline Novik, Maria Isabel Fiel, Leslie P. Cousens, Björn Magnusson, Anna Backmark, Ryan Hicks, Joel T. Dudley, Scott L. Friedman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs. We used a computational drug repositioning strategy to uncover a novel therapy for NASH, identifying a GABA-B receptor agonist, AZD3355 (Lesogaberan)
Externí odkaz:
https://doaj.org/article/b83db01028b94994911b0442d41b0959
Autor:
Farida Ahangari, Christine Becker, Daniel G. Foster, Maurizio Chioccioli, Meghan Nelson, Keriann Beke, Xing Wang, Aurelien Justet, Taylor Adams, Benjamin Readhead, Carly Meador, Kelly Correll, Loukia N. Lili, Helen M. Roybal, Kadi-Ann Rose, Shuizi Ding, Thomas Barnthaler, Natalie Briones, Giuseppe DeIuliis, Jonas C. Schupp, Qin Li, Norihito Omote, Yael Aschner, Lokesh Sharma, Katrina W. Kopf, Björn Magnusson, Ryan Hicks, Anna Backmark, Charles S. Dela Cruz, Ivan Rosas, Leslie P. Cousens, Joel T. Dudley, Naftali Kaminski, Gregory P. Downey
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 206:1463-1479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ff1d88506d695f84699d6c88253f8e
https://doi.org/10.1164/rccm.202010-3832oc
https://doi.org/10.1164/rccm.202010-3832oc
Autor:
Farida Ahangari, Christine Becker, Daniel G. Foster, Maurizio Chioccioli, Meghan Nelson, Keriann Beke, Xing Wang, Benjamin Readhead, Carly Meador, Kelly Correll, Loukia Lili, Helen M. Roybal, Kadi-Ann Rose, Shuizi Ding, Thomas Barnthaler, Natalie Briones, Giuseppe Deluliis, Jonas C. Schupp, Qin Li, Norihito Omote, Yael Aschner, Katrina W. Kopf, Björn Magnusson, Ryan Hicks, Anna Backmark, Leslie P. Cousens, Joel T. Dudley, Naftali Kaminski, Gregory P. Downey
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and often fatal disorder. Two FDA approved anti-fibrotic drugs, nintedanib and pirfenidone, slow the rate of decline in lung function, but responses are variable and side effects are comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdaa42632cbc2204f92aadf099cae97
https://doi.org/10.1101/2022.01.04.474955
https://doi.org/10.1101/2022.01.04.474955
Autor:
Christine Becker, Leslie P. Cousens, Ryan Hicks, Scott L. Friedman, Joel T. Dudley, Jacqueline Buros Novik, Dipankar Bhattacharya, Maria Isabel Fiel, Björn Magnusson, Nicolas Goossens, Anna Backmark, Benjamin Readhead
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs. We used a computational drug repositioning strategy to uncover a novel therapy for NASH, identifying a GABA-B receptor agonist, AZD3355 (Lesogaberan) previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e4d2669d7d9d98eaeaca3a049a1e4e
https://doi.org/10.1038/s41598-021-99008-2
https://doi.org/10.1038/s41598-021-99008-2
Autor:
Catherine Bardelle, Rob Howes, Roger Clark, Mark Wigglesworth, Mei Ding, Wendy Williams, Tyrrell Norris, Anna Backmark
Publikováno v:
SLAS Discovery. 23:719-731
Flow cytometry is a powerful tool providing multiparametric analysis of single cells or particles. The introduction of faster plate-based sampling technologies on flow cytometers has transformed the technology into one that has become attractive for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5f9f95ad6bcf550169b3131e628a10
https://doi.org/10.1177/2472555218775074
https://doi.org/10.1177/2472555218775074
Publikováno v:
Protein Science. 22:1124-1132
Screening of protein variants requires specific detection methods to assay protein levels and stability in crude mixtures. Many strategies apply fluorescence-detection size-exclusion chromatography (FSEC) using green fluorescent protein (GFP) fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3ac490410f6c7953ff97a3b9638ee1
https://doi.org/10.1002/pro.2297
https://doi.org/10.1002/pro.2297
Publikováno v:
Molecular Membrane Biology. 26:215-227
Membrane proteins are key players in all living cells. To achieve a better understanding of membrane protein function, significant amounts of purified protein are required for functional and structural analyses. Overproduction of eukaryotic membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bea8e1b8dc09104f7e5400bd45cd5fb
https://doi.org/10.1080/09687680902862085
https://doi.org/10.1080/09687680902862085
Autor:
Urszula Kosinska-Eriksson, Maria Fellert, Kristina Hedfalk, Rob Horsefield, Anna Backmark, Urban Johanson, Richard Neutze, Maria Nyblom, Per Kjellbom, Kristina Nordén, Susanna Törnroth-Horsefield, Karin Lindkvist-Petersson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:1183-1186
This work presents a comparison of the crystal packing of three eukaryotic membrane proteins: human aquaporin 1, human aquaporin 5 and a spinach plasma membrane aquaporin. All were purified from expression constructs both with and without affinity ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e1724cc008de0634ad1233098fad73
https://doi.org/10.1107/s090744490802948x
https://doi.org/10.1107/s090744490802948x
Autor:
Rob Horsefield, Richard Neutze, Maria Fellert, Kristina Nordén, Jan Kvassman, Per Kjellbom, Anke C. Terwisscha van Scheltinga, Susanna Törnroth-Horsefield, Anna Backmark, Urban Johanson
Publikováno v:
Proceedings of the National Academy of Sciences, 105(36). NATL ACAD SCIENCES
Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear. AQ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f55adb6a924e293940a1fbb7501a74
https://research.rug.nl/en/publications/73801ed4-a396-46e0-9d55-db50eb09e305
https://research.rug.nl/en/publications/73801ed4-a396-46e0-9d55-db50eb09e305