Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anna Baccei"'
Autor:
Junjie Lu, Anna Baccei, Edroaldo Lummertz da Rocha, Christelle Guillermier, Sean McManus, Lydia A. Finney, Cheng Zhang, Matthew L. Steinhauser, Hu Li, Paul H. Lerou
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 48-55 (2018)
Differentiation of human pluripotent stem cells towards definitive endoderm (DE) is the critical first step for generating cells comprising organs such as the gut, liver, pancreas and lung. This in-vitro differentiation process generates a heterogene
Externí odkaz:
https://doaj.org/article/e8297ed74daf4461b1d8abd072ac4c1b
Autor:
Jijun Cheng, Christine A. Roden, Wen Pan, Shu Zhu, Anna Baccei, Xinghua Pan, Tingting Jiang, Yuval Kluger, Sherman M. Weissman, Shangqin Guo, Richard A. Flavell, Ye Ding, Jun Lu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The interrogation of noncoding regions of the genome with CRISPR strategies requires dense and, ideally, inexpensive libraries to ensure coverage and customisation. Here the authors present 'Molecular Chipper' that uses fragmentation to generate guid
Externí odkaz:
https://doaj.org/article/18430b661da84ddb83ebbefbef3dc891
Autor:
Junjie Lu, Hu Li, Ming Hu, Takayo Sasaki, Anna Baccei, David M. Gilbert, Jun S. Liu, James J. Collins, Paul H. Lerou
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 70-78 (2014)
Cell-fate change involves significant genome reorganization, including changes in replication timing, but how these changes are related to genetic variation has not been examined. To study how a change in replication timing that occurs during reprogr
Externí odkaz:
https://doaj.org/article/f22cd49a205d42bea871fc2318ab3275
Autor:
Bryan R Gorman, Junjie Lu, Anna Baccei, Nathan C Lowry, Jeremy E Purvis, Rami S Mangoubi, Paul H Lerou
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116037 (2014)
Human pluripotent stem (hPS) cells are a potential source of cells for medical therapy and an ideal system to study fate decisions in early development. However, hPS cells cultured in vitro exhibit a high degree of heterogeneity, presenting an obstac
Externí odkaz:
https://doaj.org/article/d220f9786bc64b4d81df4673123f7e0d
Publikováno v:
Stem Cells and Development. 25:740-747
Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and sel
Autor:
Cheng Zhang, Junjie Lu, Christelle Guillermier, Sean McManus, Hu Li, Anna Baccei, Edroaldo Lummertz da Rocha, Paul H. Lerou, Matthew L. Steinhauser, Lydia Finney
Publikováno v:
Stem Cell Research, Vol 28, Iss, Pp 48-55 (2018)
Differentiation of human pluripotent stem cells towards definitive endoderm (DE) is the critical first step for generating cells comprising organs such as the gut, liver, pancreas and lung. This in-vitro differentiation process generates a heterogene
Autor:
Jun S. Liu, Hu Li, Takayo Sasaki, Paul H. Lerou, David M. Gilbert, Anna Baccei, James J. Collins, Ming Hu, Junjie Lu
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 70-78 (2014)
SUMMARY Cell-fate change involves significant genome reorganization, including changes in replication timing, but how these changes are related to genetic variation has not been examined. To study how a change in replication timing that occurs during
Autor:
Anna Baccei, Tan A. Ince, Mark D. Fleming, Katelyn E. Gagne, Rebecca L. Zon, Erin M. McLoughlin, Odelya Hartung, Ellis J. Neufeld, Paul H. Lerou, George Q. Daley, Suneet Agarwal, Anne Cherry, Bryan L. Gorman, Justine D. Miller, Jin Zhang
Publikováno v:
Stem Cells. 31:1287-1297
In congenital mitochondrial DNA (mtDNA) disorders, a mixture of normal and mutated mtDNA (termed heteroplasmy) exists at varying levels in different tissues, which determines the severity and phenotypic expression of disease. Pearson marrow pancreas
Autor:
Yuval Kluger, Ye Ding, Tingting Jiang, Shu Zhu, Sherman M. Weissman, Jun Lu, Jijun Cheng, Shangqin Guo, Wen Pan, Xinghua Pan, Christine Roden, Anna Baccei, Richard A. Flavell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to interrogate functional elements in noncoding r
Autor:
Michael R. Hughes, Ryan Vander Werff, Jing Zhou, Anna Baccei, Vishesh Agrawal, Albert Q. Lam, Benjamin S. Freedman, Derek T. Peters, Theodore I. Steinman, Paul H. Lerou, Hongxia Fu, Kiran Musunuru, Craig R. Brooks, Junjie Lu, Kelly M. McNagny, Michelle Li, Ryuji Morizane, M. Todd Valerius, Andrew M. Siedlecki, Joseph V. Bonventre, Abdelaziz F. Saad
Publikováno v:
Nature Communications
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organi