Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Anna B. Osipovich"'
Autor:
Mark A. Magnuson, Anna B. Osipovich
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intr
Externí odkaz:
https://doaj.org/article/4e7ff2126f354766aee0e9a2e539acda
Autor:
Anna B. Osipovich, Frank Y. Zhou, Judy J. Chong, Linh T. Trinh, Mathew A. Cottam, Shristi Shrestha, Jean-Philippe Cartailler, Mark A. Magnuson
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101811- (2023)
Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a
Externí odkaz:
https://doaj.org/article/c960991850aa4a3a86d2b2985abf0881
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Kung-Hsien Ho, Anissa Jayathilake, Yagan Mahircan, Aisha Nour, Anna B. Osipovich, Mark A. Magnuson, Guoqiang Gu, Irina Kaverina
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105938- (2023)
Summary: Glucose stimulation induces the remodeling of microtubules, which potentiates insulin secretion in pancreatic β-cells. CAMSAP2 binds to microtubule minus ends to stabilize microtubules in several cultured clonal cells. Here, we report that
Externí odkaz:
https://doaj.org/article/fcefcd0718854146891e21c7a8ebb26a
Autor:
Linh T. Trinh, Anna B. Osipovich, Leesa Sampson, Jonathan Wong, Chris V.E. Wright, Mark A. Magnuson
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104905- (2022)
Summary: Sox17 gene expression is essential for both endothelial and endodermal cell differentiation. To better understand the genetic basis for the expression of multiple Sox17 mRNA forms, we identified and performed CRISPR/Cas9 mutagenesis of two e
Externí odkaz:
https://doaj.org/article/a59f4090bd5640709f0bf2d8fef60857
Autor:
Sara X. Chen, Anna B. Osipovich, Alessandro Ustione, Leah A. Potter, Susan Hipkens, Rama Gangula, Weiping Yuan, David W. Piston, Mark A. Magnuson
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 4, Pp 537-547 (2011)
SUMMARY Fluorescent proteins (FPs) have great utility in identifying specific cell populations and in studying cellular dynamics in the mouse. To quantify the factors that determine both the expression and relative brightness of FPs in mouse embryoni
Externí odkaz:
https://doaj.org/article/d253bbde294843ff99801326efabda74
Autor:
Kathryn P Trogden, Justin Lee, Kai M Bracey, Kung-Hsien Ho, Hudson McKinney, Xiaodong Zhu, Goker Arpag, Thomas G Folland, Anna B Osipovich, Mark A Magnuson, Marija Zanic, Guoqiang Gu, William R Holmes, Irina Kaverina
Publikováno v:
eLife, Vol 10 (2021)
Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize mouse islets to determine how microtubules (MTs) affect secretion toward the vascular extracellular
Externí odkaz:
https://doaj.org/article/9506901faa9e40da9a5c9f740c2f02ad
Autor:
Linh T Trinh, Anna B Osipovich, Bryan Liu, Shristi Shrestha, Jean-Philippe Cartailler, Christopher V E Wright, Mark A Magnuson
Publikováno v:
Stem Cells.
During early embryogenesis, the transcription factor SOX17 contributes to hepato-pancreato-biliary system formation and vascular-hematopoietic emergence. To better understand Sox17 function in the developing endoderm and endothelium, we developed a d
Autor:
Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T. Samuel, Karrie D. Dudek, Anna B. Osipovich, Mark A. Magnuson, Jeffrey Sklar, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Single-nucleotide polymorphisms in the human juxtaposed with another zinc finger protein 1 ( JAZF1 ) gene have repeatedly been associated with both type 2 diabetes (T2D) and height in multiple genome-wide association studies (GWAS); however, the mech
Autor:
Hui-Young, Lee, Hye Rim, Jang, Hui, Li, Varman T, Samuel, Karrie D, Dudek, Anna B, Osipovich, Mark A, Magnuson, Jeffrey, Sklar, Gerald I, Shulman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Single-nucleotide polymorphisms in the human juxtaposed with another zinc finger protein 1 (