Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Anna B. Loveland"'
Autor:
Anna B. Loveland, Egor Svidritskiy, Denis Susorov, Soojin Lee, Alexander Park, Sarah Zvornicanin, Gabriel Demo, Fen-Biao Gao, Andrei A. Korostelev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The expansion of GGGGCC repeats in the C9ORF72 gene results in the production of disease causing abnormal proteins with polymeric glycine-arginine (poly-GR) and polymeric glycine-proline (poly-PR). Here the authors demonstrate a structural mechanism
Externí odkaz:
https://doaj.org/article/925d6997c2a04e6b9e28ab867faf90be
Autor:
Christine E. Carbone, Anna B. Loveland, Howard B. Gamper, Ya-Ming Hou, Gabriel Demo, Andrei A. Korostelev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
EF-G drives ribosomal translocation along mRNA. Time-resolved cryo-EM captured translocation with EF-G•GTP—without inhibitors—revealing how EF-G uses ribosome fluctuations to drive translocation and GTP hydrolysis to leave at the right moment.
Externí odkaz:
https://doaj.org/article/4bea5e8abd3d4ecd81046f7ade0b17b2
Autor:
Gabriel Demo, Howard B. Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, Andrei A. Korostelev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the rib
Externí odkaz:
https://doaj.org/article/9e96fbbefbf946cca2e64e5aa10017b3
Autor:
Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vázquez-Laslop, Andrei A. Korostelev, Alexander S. Mankin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S
Externí odkaz:
https://doaj.org/article/97ce74dddff14abd9b4d20a9c96f526d
Autor:
Hung-Lun Hsu, Alexander Brown, Anna B. Loveland, Anoushka Lotun, Meiyu Xu, Li Luo, Guangchao Xu, Jia Li, Lingzhi Ren, Qin Su, Dominic J. Gessler, Yuquan Wei, Phillip W. L. Tai, Andrei A. Korostelev, Guangping Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability,
Externí odkaz:
https://doaj.org/article/143cfb7a1596401ea3955f040a832c0f
Publikováno v:
eLife, Vol 8 (2019)
Protein synthesis ends when a ribosome reaches an mRNA stop codon. Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nascent protein, and then dissociate to allow ribosome recycling. To visualize termination by RF2,
Externí odkaz:
https://doaj.org/article/0da449cd4d5640eea3f29f0c324f4e4b
Autor:
Gabriel Demo, Aviram Rasouly, Nikita Vasilyev, Vladimir Svetlov, Anna B Loveland, Ruben Diaz-Avalos, Nikolaus Grigorieff, Evgeny Nudler, Andrei A Korostelev
Publikováno v:
eLife, Vol 6 (2017)
In bacteria, mRNA transcription and translation are coupled to coordinate optimal gene expression and maintain genome stability. Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and the translational machinery. We pres
Externí odkaz:
https://doaj.org/article/f6133fee95ef45eba7820b5d222d7c09
Autor:
Anna B Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F Brilot, Nikolaus Grigorieff, Andrei A Korostelev
Publikováno v:
eLife, Vol 5 (2016)
Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amin
Externí odkaz:
https://doaj.org/article/e2ce5e5ca22a4cc7896a95764e229e8b
Autor:
Anoushka Lotun, Jia Li, Guangping Gao, Anna B. Loveland, Qin Su, Dominic J. Gessler, Alexander Brown, Meiyu Xu, Hung-Lun Hsu, Phillip W. L. Tai, Li Luo, Lingzhi Ren, Andrei A. Korostelev, Yuquan Wei, Guangchao Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human gene therapy. Three serotype capsids, AAV1, AAV2, and AAV9, have been approved for commercial use in patients, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84971fdcf7cd9b0a08ea7c4a604e7c9f
http://link.springer.com/article/10.1038/s41467-020-17047-1
http://link.springer.com/article/10.1038/s41467-020-17047-1
Autor:
Anna B. Loveland, Amira Kefi, Nora Vázquez-Laslop, Kaspar Reier, Shijie Huang, Teresa Szal, Jaanus Remme, Nikolay A. Aleksashin, Andrei A. Korostelev, Dorota Klepacki, Alexander S. Mankin, Luc Jaeger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a29b7ff3dade09fd7d94c1924d52bb
