Výsledky vyhledávání - "Anna B. Breier"

Synergistic Cytotoxicity from Drugs and Cytokines In Vitro as an Approach to Classify Drugs According to Their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof-of-Concept Study

Autor: Patricia E. Ganey, Gurpreet Kaur, Ashley R. Maiuri, Sarah L. Hession, Anna B. Breier, Jonathan Turkus, Theresa A. Lansdell, Bronlyn Wassink, Robert A. Roth

Publikováno v: The Journal of pharmacology and experimental therapeutics. 362(3)

Idiosyncratic drug-induced liver injury (IDILI) typically occurs in a small fraction of patients and has resulted in removal of otherwise efficacious drugs from the market. Current preclinical testing methods are ineffective in predicting which drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dadb647ce324e09f0ed5970bf2d20f
https://pubmed.ncbi.nlm.nih.gov/28687704

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Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines

Autor: Robert A. Roth, Jonathan Turkus, Anna B. Breier, Ashley R. Maiuri, Patricia E. Ganey

Diclofenac (DCLF) is a widely used non-steroidal anti-inflammatory drug that is associated with idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanisms of DCLF-induced liver injury are unknown; however, patients with certain inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40321a8831a5d2fb6cebc82fe5be9d8
https://europepmc.org/articles/PMC4900219/

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Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases

Autor: Patricia E. Ganey, Lukas F.J. Gora, Robert A. Roth, Anna B. Breier, Ashley R. Maiuri, Robert V. Parkins

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequent causes of idiosyncratic, drug-induced liver injury (IDILI). Mechanisms of IDILI are unknown, but immune responses are suspected to underlie them. In animal models of IDILI, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee77a5170bcd0972e025f321e104e82
https://europepmc.org/articles/PMC4607747/

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Drugs associated with idiosyncratic hepatotoxicity synergize with cytokines to kill hepatocytes in vitro

Autor: Jonathan Turkus, Robert V. Parkins, Patricia E. Ganey, Theresa A. Lansdell, Gurpreet Kaur, Ashley R. Maiuri, Robert A. Roth, Anna B. Breier

Publikováno v: The FASEB Journal. 29

Idiosyncratic drug-induced liver injury (IDILI) occurs in a small fraction of patients and often results in removal of otherwise efficacious drugs from the market. The mechanisms of IDILI are unkno...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1598ed3e54e661c1bb5dc156f54bcafc
https://doi.org/10.1096/fasebj.29.1_supplement.937.7

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