Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anna Ashton"'
Autor:
Lewis Taylor, Steven Walsh, Anna Ashton, Norbert Varga, Sejal Kapoor, Charlotte George, Aarti Jagannath
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17362- (2023)
Whilst the regulation of chromatin accessibility and its effect on gene expression have been well studied in eukaryotic species, the role of chromatin dynamics and 3D organisation in genome reduced bacteria remains poorly understood [1,2]. In this st
Externí odkaz:
https://doaj.org/article/0d8df407371b4758b8f75dee635fd68f
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Autor:
Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar Vasudevan, Aarti Jagannath
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105877- (2023)
Summary: Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection follow
Externí odkaz:
https://doaj.org/article/a1abe26ff9904b94aa701cbd4db3ba41
Autor:
Florence Rawlings-Mortimer, L Sophie Gullino, Sebastian Rühling, Anna Ashton, Chris Barkus, Heidi Johansen-Berg
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281264 (2023)
The atypical protein tyrosine phosphatase enzyme, dual-specificity phosphate 15 (DUSP15) is thought to be activated by myelin regulatory factor (MyRF) and to have a role in oligodendrocyte differentiation. Here, we assess whether Dusp15 is reduced in
Externí odkaz:
https://doaj.org/article/974a2df9d7964aba9f6d73ed3f94ca86
Autor:
Catherine E. Reavey, Adam S. Walker, Stephen P. Joyce, Lucy Broom, Alan Willse, Kyla Ercit, Mattia Poletto, Zoe H. Barnes, Thea Marubbi, Bartlomiej J. Troczka, David Treanor, Katherine Beadle, Ben Granville, Vanessa de Mello, Joss Teal, Edward Sulston, Anna Ashton, Luxziyah Akilan, Neil Naish, Oliver Stevens, Nerys Humphreys-Jones, Simon A. J. Warner, Sian A. M. Spinner, Nathan R. Rose, Graham Head, Neil I. Morrison, Kelly J. Matzen
Publikováno v:
BMC Biotechnology, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background The fall armyworm, Spodoptera frugiperda, is a significant and widespread pest of maize, sorghum, rice, and other economically important crops. Successful management of this caterpillar pest has historically relied upon applicatio
Externí odkaz:
https://doaj.org/article/ed088009eea44d11bcca5f43b931b0ef
Autor:
Sanskar Ranglani, Anna Ashton, Kashif Mahfooz, Joanna Komorowska, Alexandru Graur, Nadine Kabbani, Sara Garcia-Rates, Susan Greenfield
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9961 (2023)
T14 modulates calcium influx via the α-7 nicotinic acetylcholine receptor to regulate cell growth. Inappropriate triggering of this process has been implicated in Alzheimer’s disease (AD) and cancer, whereas T14 blockade has proven therapeutic pot
Externí odkaz:
https://doaj.org/article/f95c889a532e4c2daa64d25873164f90
Publikováno v:
Cells, Vol 12, Iss 2, p 286 (2023)
The pineal gland is integral to the circadian timing system due to its role in nightly melatonin production. Retinoic acid (RA) is a potent regulator of gene transcription and has previously been found to exhibit diurnal changes in synthesis and sign
Externí odkaz:
https://doaj.org/article/41a7ae3635bc4c499ac409e434d65ac1
Autor:
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103144- (2021)
Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the re
Externí odkaz:
https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 729 (2022)
Circadian rhythms are essential for the survival of all organisms, enabling them to predict daily changes in the environment and time their behaviour appropriately. The molecular basis of such rhythms is the circadian clock, a self-sustaining molecul
Externí odkaz:
https://doaj.org/article/04132534e56b4cfc97fe5fc42ba9d05a
Disrupted Sleep and Circadian Rhythms in Schizophrenia and Their Interaction With Dopamine Signaling
Autor:
Anna Ashton, Aarti Jagannath
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Sleep and circadian rhythm disruption (SCRD) is a common feature of schizophrenia, and is associated with symptom severity and patient quality of life. It is commonly manifested as disturbances to the sleep/wake cycle, with sleep abnormalities occurr
Externí odkaz:
https://doaj.org/article/2045cae66e90484fb905394e50bde030
Autor:
Greenfield, Sanskar Ranglani, Anna Ashton, Kashif Mahfooz, Joanna Komorowska, Alexandru Graur, Nadine Kabbani, Sara Garcia-Rates, Susan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9961
T14 modulates calcium influx via the α-7 nicotinic acetylcholine receptor to regulate cell growth. Inappropriate triggering of this process has been implicated in Alzheimer’s disease (AD) and cancer, whereas T14 blockade has proven therapeutic pot