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pro vyhledávání: '"Anna Antosiewicz"'
Autor:
Maria Magdalena Klimecka, Anna Antosiewicz, Matylda Anna Izert, Patrycja Emanuela Szybowska, Piotr Krzysztof Twardowski, Clara Delaunay, Maria Wiktoria Górna
Publikováno v:
Molecules, Vol 26, Iss 19, p 5936 (2021)
The ssrA degron is commonly used in fusion proteins to control protein stability in bacteria or as an interaction module. These applications often rely on the modular activities of the ssrA tag in binding to the SspB adaptor and in engaging the ClpXP
Externí odkaz:
https://doaj.org/article/eafbe9cd3084470188c4c160f95a90be
Autor:
Anna Antosiewicz, Wojciech Rode, Dorota Przybylska, Anna Kowalkowska, Joanna Szczepanowska, Grazyna Mosieniak, Adam Jarmuła, Joanna Cieśla
Publikováno v:
Journal of biomolecular structuredynamics. 35(7)
Enzymes involved in thymidylate biosynthesis, thymidylate synthase (TS), and dihydrofolate reductase (DHFR) are well-known targets in cancer chemotherapy. In this study, we demonstrated for the first time, that human TS and DHFR form a strong complex
Publikováno v:
Biosensorsbioelectronics. 64
Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) play essential role in DNA synthesis, repair and cell division by catalyzing two subsequent reactions in thymidylate biosynthesis cycle. The lack of either enzyme leads to thymineless death