Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anna A. Zabierek"'
Autor:
Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshall
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this
Externí odkaz:
https://doaj.org/article/e1af821b8d2243da83151c870eaab2ae
Autor:
Matthew G. Stanton, Sanjeev Munshi, Ian W. Davies, Kaleen Konrad Childers, Michael Hutton, Lee Warren, Mansuo Hayashi, Anna A. Zabierek, Alan B. Northrup, Alexander A. Szewczak, Hugh Nuthall, Andrew M. Haidle, Ben Munoz, Dapeng Chen, Hua-Poo Su, Yongquan Hou, Jason D. Katz, Andreas Harsch, Michael D. Altman, James P. Jewell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:114-120
The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for
Autor:
Andrew M. Haidle, Alan B. Northrup, Alexander A. Szewczak, Lee Warren, Jason D. Katz, James P. Jewell, Mansuo Hayashi, Hugh Nuthall, Andreas Harsch, Michael D. Altman, Ian W. Davies, Dapeng Chen, Kaleen Konrad Childers, Michael Hutton, Anna A. Zabierek, Matthew G. Stanton, Yongquan Hou, Ben Munoz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:109-113
Attempts to optimize pharmacokinetic properties in a promising series of pyrrolopyrimidinone MARK inhibitors for the treatment of Alzheimer's disease are described. A focus on physical properties and ligand efficiency while prosecuting this series af
Autor:
Thomas S. Rush, Lin Xu, Paul Tempest, Grace Chan, Eric Bachman, Melaney Bouthillette, Craig Rosenstein, Anjili Mathur, Anna A. Zabierek, Andrew M. Haidle, Kaleen Konrad Childers, Jonathan R. Young, Jan-Rung Mo, Michael D. Altman, C. Gary Marshall
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(8)
A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric replacement of a urea substituent by a pyridyl ring. Issues of chemical and metabolic stabil
Publikováno v:
Tetrahedron Letters. 49:2996-2998
A novel synthesis of N1 alkyl-substituted pyrazoles with a free amino group at the C4 position is described. Commercially available 4-nitropyrazole was found to readily undergo Mitsunobu reactions with primary and secondary alcohols. Subsequent reduc
Autor:
Scott C. Berk, Candia M. Kenific, Julie E. Hamill, Paul Secrist, Paul Tempest, Jonathan C. Cruz, Andreas Harsch, Judith C. Fleming, Solomon Kattar, Bethany Hughes, Laura Surdi, Hongmei Wang, William K. Dahlberg, Nicole Ozerova, Thomas A. Miller, Melissa Chenard, Astrid M. Kral, Richard E. Middleton, Joey L. Methot, Alexander A. Szewczak, Anna A. Zabierek
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(4)
The successful application of both solid and solution phase library synthesis, combined with tight integration into the medicinal chemistry effort, resulted in the efficient optimization of a novel structural series of selective HDAC1/HDAC2 inhibitor
Publikováno v:
ChemInform. 39
A novel synthesis of N1 alkyl-substituted pyrazoles with a free amino group at the C4 position is described. Commercially available 4-nitropyrazole was found to readily undergo Mitsunobu reactions with primary and secondary alcohols. Subsequent reduc
Autor:
Melaney Bouthillette, Lin Xu, Brian Dolinski, C. Gary Marshall, Andrew M. Haidle, Kevin D. Little, Hong Yin, Anjili Mathur, Linda Lee, Shuxia Zhao, Alexander A. Szewczak, Weisheng Zhang, Yanhong Ma, Brandon M. Taoka, Erin O’Hare, Wenxian Wang, Eric Bachman, Jan-Rung Mo, Johnny E. Kopinja, Jongwon Lim, Joe Zhu, Anna A. Zabierek, Deborah Walker, Kaleen M. Childers, Jonathan R. Young, Yuxun Wang, Manfred Kraus, Dan Aleksandrowicz, Ryan D. Otte
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
PLoS ONE
PLoS ONE
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this
Autor:
Kattar SD; Department of Drug Design and Optimization, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA. sam_kattar@merck.com, Surdi LM, Zabierek A, Methot JL, Middleton RE, Hughes B, Szewczak AA, Dahlberg WK, Kral AM, Ozerova N, Fleming JC, Wang H, Secrist P, Harsch A, Hamill JE, Cruz JC, Kenific CM, Chenard M, Miller TA, Berk SC, Tempest P
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Feb 15; Vol. 19 (4), pp. 1168-72. Date of Electronic Publication: 2008 Dec 25.