Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anna A. Skuredina"'
Publikováno v:
Polysaccharides, Vol 4, Iss 4, Pp 343-357 (2023)
The aim of this work was to investigate the physico-chemical and biological properties of cyclodextrin-based polymers by the example of interaction with human serum albumin, erythrocytes, and bacteria to understand the prospects of their application
Externí odkaz:
https://doaj.org/article/97b94d53b75041a2b4c0cd7f9b71fb68
Publikováno v:
Chemistry, Vol 5, Iss 3, Pp 1942-1960 (2023)
Here, we propose a drug delivery system for ciprofloxacin (CF) based on cyclodextrin (CD) polymer. We obtained a 3D matrix system with encapsulated drug molecules by crosslinking CF+CD non-covalent complexes with 1.6-hexamethylene isocyanate. The obt
Externí odkaz:
https://doaj.org/article/bf8815b220244b44a4b08d67b385fe36
Autor:
Irina M. Le-Deygen, Anastasia S. Safronova, Polina V. Mamaeva, Ilya M. Kolmogorov, Anna A. Skuredina, Elena V. Kudryashova
Publikováno v:
Biophysica, Vol 2, Iss 4, Pp 353-365 (2022)
We have investigated the nature of the interaction of small organic drug molecules with lipid membranes of various compositions. Using infrared spectroscopy and differential scanning calorimetry methods, we studied the role of the structure of the ac
Externí odkaz:
https://doaj.org/article/92eabb9b2c9d48719868f085240bbd15
Autor:
Irina M. Le-Deygen, Viktoria V. Rokosovina, Anna A. Skuredina, Ivan D. Yakimov, Elena V. Kudryashova
Publikováno v:
Future Pharmacology, Vol 2, Iss 3, Pp 330-346 (2022)
Liposomal complexes with mucoadhesive polymers, e.g., mannosylated chitosan, are considered as prospective antituberculosis drug delivery systems. The properties of such complexes can be critically affected by the charge and phase state of liposomes.
Externí odkaz:
https://doaj.org/article/0f8e5c8f0ee04719aa0440655a3904b4
Autor:
Irina M. Le-Deygen, Anastasia S. Safronova, Polina V. Mamaeva, Anna A. Skuredina, Elena V. Kudryashova
Publikováno v:
Biophysica, Vol 2, Iss 1, Pp 79-88 (2022)
In this work, we studied the effect of as on the interaction of membrane DPPC with the key antifibrotic drug pirfenidone. Liposomal forms of pirfenidone were obtained using passive loading. The addition of cholesterol reduces the loading efficiency o
Externí odkaz:
https://doaj.org/article/b5a69ea3a1ff4276a89f341f693b6625
Autor:
Irina M. Le-Deygen, Polina V. Mamaeva, Anna A. Skuredina, Anastasia S. Safronova, Natalia G. Belogurova, Elena V. Kudryashova
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 7, p 381 (2023)
The therapy of resistant forms of tuberculosis requires the simultaneous use of several drugs, in particular, a combination of rifampicin and levofloxacin. In this paper, we aimed to design a combined system for the simultaneous delivery of these dru
Externí odkaz:
https://doaj.org/article/1d658b00af9540fbb9a24560875c97e2
Autor:
Anna A. Skuredina, Linara R. Yakupova, Tatiana Yu. Kopnova, Irina M. Le-Deygen, Natalya G. Belogurova, Elena V. Kudryashova
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1598 (2023)
Respiratory infectious diseases have challenged medical communities and researchers. Ceftriaxone, meropenem and levofloxacin are widely used for bacterial infection treatment, although they possess severe side effects. To overcome this, we propose cy
Externí odkaz:
https://doaj.org/article/38860d0bf29c4f7d99251f32e425938d
Autor:
Linara R. Yakupova, Anna A. Skuredina, Pavel O. Markov, Irina M. Le-Deygen, Elena V. Kudryashova
Publikováno v:
Applied Sciences, Vol 13, Iss 6, p 3608 (2023)
Here we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures
Externí odkaz:
https://doaj.org/article/39b0ba69ebb44a56ad423415bfd40c9f
Autor:
Irina M. Le-Deygen, Anna A. Skuredina, Polina V. Mamaeva, Ilya M. Kolmogorov, Elena V. Kudryashova
Publikováno v:
Life, Vol 13, Iss 2, p 272 (2023)
In this work, we synthesized chitosan 5 kDa conjugates with β-cyclodextrins with various substituents as promising mucoadhesive carriers for the delivery of fluoroquinolones using the example of levofloxacin. The obtained conjugates were comprehensi
Externí odkaz:
https://doaj.org/article/ee4befc496c84793a2397187192da7e1
Autor:
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 228 (2023)
In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation. β-C
Externí odkaz:
https://doaj.org/article/469915022826433fa2e2c6ec29acb10a