Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Anna A. Schwendeman"'
Autor:
Jill Coghlan, Alexander Benet, Preethi Kumaran, Michael Ford, Lawrie Veale, St. John Skilton, Sergei Saveliev, Anna A. Schwendeman
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Post translational modifications (PTMs) have been shown to negatively impact protein efficacy and safety by altering its native conformation, stability, target binding and/or pharmacokinetics. One PTM in particular, shuffled disulfide bonds, has been
Externí odkaz:
https://doaj.org/article/16e26e87fd4d48209bbd271a8751d045
Autor:
Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this diso
Externí odkaz:
https://doaj.org/article/e83baffb0e3847bbafc88e3c4bd749f6
Autor:
Yonghong Luo, Yanhong Guo, Huilun Wang, Minzhi Yu, Kristen Hong, Dan Li, Ruiting Li, Bo Wen, Die Hu, Lin Chang, Jifeng Zhang, Bo Yang, Duxin Sun, Anna S. Schwendeman, Y. Eugene Chen
Publikováno v:
EBioMedicine, Vol 74, Iss, Pp 103725-(2021)
EBioMedicine
EBioMedicine
Background: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b52be70412081d1bef4ef026c6f5106
http://www.sciencedirect.com/science/article/pii/S2352396421005193
http://www.sciencedirect.com/science/article/pii/S2352396421005193
Autor:
Jill Coghlan, Jukyung Kang, John C. Fjeldsted, Daniel A. Polasky, Anna A. Schwendeman, Daniel D. Vallejo, Brandon T. Ruotolo, Ruwan T. Kurulugama, Carolina Rojas Ramírez
Publikováno v:
Analytical chemistry. 93(48)
Ion mobility-mass spectrometry (IM-MS) and collision-induced unfolding (CIU) assays of monoclonal antibody (mAb)-based biotherapeutics have proven sensitive to disulfide bridge structures, glycosylation patterns, and small molecule conjugation levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2da71fc5899695404a5193c57ef0b0f
https://pubmed.ncbi.nlm.nih.gov/34808055
https://pubmed.ncbi.nlm.nih.gov/34808055
Autor:
Ling Mei, Minzhi Yu, Yayuan Liu, Eric Weh, Mercy Pawar, Li Li, Cagri G. Besirli, Anna A. Schwendeman
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 44
Synthetic high-density lipoprotein (sHDL) and rapamycin (Rap) have both been shown to be potential treatments for age-related macular degeneration (AMD). The low aqueous solubility of Rap, however, limits its therapeutic utility. Here we used an Apol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbb9b8afb17fa40e34d7de0ba765fcc
https://pubmed.ncbi.nlm.nih.gov/35623563
https://pubmed.ncbi.nlm.nih.gov/35623563
Autor:
Denis O Sviridov, Anna A Schwendeman, Gwangseong Kim, John Stonik, Scott Turner, Alan T Remaley
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
Introduction 5A (DWLKAFYDKVAEKLKEAF-P-DWAKAAYDKAAEKAKEAA) is an apolipoprotein A-I mimetic peptide that is specific for promoting cholesterol efflux by the ABCA1 transporter and has been shown to reduce atherosclerosis and inflammation in animal mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ad1d6c9848dfdb3ff6900a84982872
https://doi.org/10.1161/atvb.33.suppl_1.a448
https://doi.org/10.1161/atvb.33.suppl_1.a448
Autor:
Li J; Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Xia Z; Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Yu M; Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Schwendeman A; Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: annaschw@umich.edu.
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Nov 08, pp. 114577. Date of Electronic Publication: 2024 Nov 08.
Autor:
Juang V; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States., Gan J; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States., Xia Z; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States., Wang Y; Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States., Schwendeman A; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: annaschw@umich.edu.
Publikováno v:
International journal of pharmaceutics [Int J Pharm] 2024 Oct 21; Vol. 667 (Pt A), pp. 124854. Date of Electronic Publication: 2024 Oct 21.
Autor:
Liu Y, Wang H, Yu M, Cai L, Zhao Y, Cheng Y, Deng Y, Zhao Y, Lu H, Wu X, Zhao G, Xue C, Liu H, Surakka I, Schwendeman A, Lu HS, Daugherty A, Chang L, Zhang J, Temel RE, Chen YE, Guo Y
Publikováno v:
MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.
Autor:
Dal-Fabbro R; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA., Yu M; Department of Pharmaceutical Sciences, College of Pharmacy and Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA., Mei L; Department of Pharmaceutical Sciences, College of Pharmacy and Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA., Sasaki H; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA., Schwendeman A; Department of Pharmaceutical Sciences, College of Pharmacy and Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA., Bottino MC; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA. mbottino@umich.edu.; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA. mbottino@umich.edu.
Publikováno v:
International journal of oral science [Int J Oral Sci] 2024 Jul 02; Vol. 16 (1), pp. 50. Date of Electronic Publication: 2024 Jul 02.