Výsledky vyhledávání - "Anna A. Plyasova"

Akademický článek

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes

Autor: Anna A. Plyasova, Dmitry D. Zhdanov

Publikováno v: Biomedicines, Vol 9, Iss 5, p 526 (2021)

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins can regulate AS in a cell type-specific manner and determine the functio

Externí odkaz: https://doaj.org/article/3010883b419b4d7c8d7b72878903f78f

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Akademický článek

Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

Autor: Anna A. Plyasova, Marina V. Pokrovskaya, Olga M. Lisitsyna, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Abdullah Hilal, Nikolay N. Sokolov, Dmitry D. Zhdanov

Publikováno v: Pharmaceuticals, Vol 13, Iss 10, p 286 (2020)

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the supp

Externí odkaz: https://doaj.org/article/fa99e70b503349f1b0ce8c3ecc48e67d

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Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors

Autor: Andrea Angeli, Anna A. Plyasova, Claudiu T. Supuran, Nikolay N. Sokolov, D. D. Zhdanov, M. V. Pokrovskaya, Alexander V. Veselovsky, Marta Ferraroni, Abdullah Hilal, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Fabrizio Carta, Emanuela Berrino, Yulia A. Gladilina, Irina I Khan

Publikováno v: Journal of medicinal chemistry. 64(15)

Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3' ends of chromosomes. Since TL-inhibitor (TI) stand-alone cancer therapy has been proven to be remarkably challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2c35ca71cc4226b0999557f8ed8828
https://pubmed.ncbi.nlm.nih.gov/34283610

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Characteristics of Tumors That Develop in Athymic Mice after Transplantation of Human Malignant CD4+ T-lymphocytes Transformed ex vivo

Autor: Anna A. Plyasova, D. V. Grishin, A. N. Gabasvili, M. V. Pokrovskaya, D. D. Zhdanov, Nikolay N. Sokolov, Yulia A. Gladilina, Vadim S. Pokrovsky, Svetlana S. Alexandrova

Publikováno v: Cell and Tissue Biology. 13:176-187

Normal human CD4+ T-lymphocytes can undergo malignant transformation during prolong cultivation in conditions of high endonuclease G (EndoG) expression or after DNA damage. The aim of this work was to study biochemical and cytogenetic features of tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8460db0c058ee1e7fcf820096a39527
https://doi.org/10.1134/s1990519x19030118

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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis

Autor: D. V. Grishin, D. D. Zhdanov, Yulia A. Gladilina, Nikolay N. Sokolov, Vladimir A. Grachev, Vadim S. Pokrovsky, Anna A. Plyasova, M. V. Pokrovskaya, Svetlana S. Alexandrova, V. S. Orlova

Publikováno v: Biochimie. 157:158-176

Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f37272fb6e25b1207dcc0e2ed2a169a7
https://doi.org/10.1016/j.biochi.2018.11.020

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Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

Autor: D. D. Zhdanov, Anna A. Plyasova, M. V. Pokrovskaya, Nikolay N. Sokolov, Svetlana S. Alexandrova, Olga M Lisitsyna, Vadim S. Pokrovsky, Abdullah Hilal

Publikováno v: Pharmaceuticals
Pharmaceuticals, Vol 13, Iss 286, p 286 (2020)
Volume 13
Issue 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667cf7b0a2c5add3f13ba7ddadc38c84
http://europepmc.org/articles/PMC7650658

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Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of normal human CD4

Autor: Nikolay N. Sokolov, Anna A. Plyasova, M. V. Pokrovskaya, D. D. Zhdanov, Yulia A. Gladilina, Vadim S. Pokrovsky, Svetlana S. Alexandrova

Publikováno v: Biochimie. 174

The nuclease activity of deoxyribonuclease 1 (DNase I) is regulated by alternative splicing (AS) of its mRNA. The aim of this study was to define the ability of a splice-switching oligonucleotide (SSO) that base-paired with DNase I pre-mRNA to induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e3bf4ae609827abdc9e1053398e5a3
https://pubmed.ncbi.nlm.nih.gov/32315661

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Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of human CD4

Autor: D. V. Grishin, Tatiana A. Lobaeva, V. S. Orlova, Anna A. Plyasova, M. V. Pokrovskaya, Svetlana S. Alexandrova, Vadim S. Pokrovsky, Yulia A. Gladilina, D. D. Zhdanov, Vladimir A. Grachev, Nikolay N. Sokolov

Publikováno v: Biochemical and biophysical research communications. 509(3)

Telomerase activity is regulated at the mRNA level by alternative splicing (AS) of its catalytic subunit hTERT. The aim of this study was to define the ability of splice-switching oligonucleotides (SSOs) that pair with hTERT pre-mRNA to induce AS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79d9f6846f2641f7f356ef10d04ddcc
https://pubmed.ncbi.nlm.nih.gov/30612734

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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4

Autor: Dmitry D, Zhdanov, Yulia A, Gladilina, Vadim S, Pokrovsky, Dmitry V, Grishin, Vladimir A, Grachev, Valentina S, Orlova, Marina V, Pokrovskaya, Svetlana S, Alexandrova, Anna A, Plyasova, Nikolay N, Sokolov

Publikováno v: Biochimie. 157

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6dd5c2c69281a07102e77915edd2b98
https://pubmed.ncbi.nlm.nih.gov/30521874

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