Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Anna A. Dickson"'
1
Akademický článek
A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis
Autor: Anna S. Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M. Ortmann, James A. West, Norbert Volkmar, Anthony W. Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J. Lehner, James A. Nathan
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cholesterol biosynthesis is a highly regulated, oxygen-dependent pathway, vital for cell membrane integrity and growth. In fungi, the dependency on oxygen for sterol production has resulted in a shared transcriptional response, resembling pr
Externí odkaz: https://doaj.org/article/c87d491caba847fcaeae18fb670de9f1
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4
Akademický článek
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS
Autor: Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Bertini, Michael P Murphy, James A Nathan, Carlo Viscomi, Erika Fernandez‐Vizarra, Massimo Zeviani
Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-21 (2018)
Abstract Loss‐of‐function mutations in APOPT1, a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome c oxidase (COX) deficiency. Although the genetic
Externí odkaz: https://doaj.org/article/215a8a7301c4477ba2ac4a4276753ce7
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5
Akademický článek
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
Autor: Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Publikováno v: eLife, Vol 7 (2018)
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions,
Externí odkaz: https://doaj.org/article/f84da21acd8c46149f6d640a9199b032
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7
Clickable, selective, and cell-permeable activity-based probe of human cathepsin B – Minimalistic approach for enhanced selectivity
Autor: Faiza Rafi, Karl R. Fath, Anna A. Dickson, Tuhin Das, Guoshen Li, Gopal Subramaniam, Sarbani Ghoshal, Sanjai K. Pathak, Pratikkumar Rathod, Dibyendu Dana, Suneeta Paroly, Ashif I. Bhuiyan, Emmanuel J. Chang
Publikováno v: Bioorganic Chemistry. 117:105463
Human cathepsin B is a cysteine-dependent protease whose roles in both normal and diseased cellular states remain yet to be fully delineated. This is primarily due to overlapping substrate specificities and lack of unambiguously annotated physiologic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bef6f0f68d423d40501e60e4599276b
https://doi.org/10.1016/j.bioorg.2021.105463
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8
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS
Autor: Elizabeth C. Hinchy, Raffaele Cerutti, Rosalba Carrozzo, James A. Nathan, Erika Fernandez-Vizarra, Michael P. Murphy, Carlo Viscomi, Alba Signes, Daniele Ghezzi, Cristiane Benincá, Massimo Zeviani, Anna S Dickson, Enrico Bertini
Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 1, Pp n/a-n/a (2019)
Loss‐of‐function mutations in APOPT1, a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome c oxidase (COX) deficiency. Although the genetic associati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cf34617be0de6b73eb291221a3ac15
https://pubmed.ncbi.nlm.nih.gov/30552096
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