Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

Autor: Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim

Publikováno v: Scientia Pharmaceutica, Vol 87, Iss 2, p 12 (2019)

According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2

Externí odkaz: https://doaj.org/article/15d84e402f4a47c8b7cc93a5cb476bc4

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

Autor: Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim

Publikováno v: Scientia Pharmaceutica, Vol 86, Iss 4, p 50 (2018)

The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have

Externí odkaz: https://doaj.org/article/7e25eb729712445a907600312c1a7b5e

4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties

Autor: Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Svitlana V. Shishkina, Natali I. Voloshchuk, Oxana V. Malchenko

Publikováno v: Scientia Pharmaceutica, Vol 86, Iss 1, p 9 (2018)

In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of it

Externí odkaz: https://doaj.org/article/39fdab6f4d7041c0900f2688dd3593db

Design, Synthesis and Biological Evaluation of Novel N-Alkyl-4-Methyl-2,2- Dioxo-1H-2λ ⁶ ,1-Benzothiazine-3-Carboxamides as Promising Analgesics.

Autor: Ukrainets I; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine., Burian A; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine., Voloshchuk N; Department of Pharmacology, N.I. Pirogov Vinnitsa National Medical University, 56 Pirogov st., 21018 Vinnitsa, Ukraine., Taran I; Department of Pharmacology, N.I. Pirogov Vinnitsa National Medical University, 56 Pirogov st., 21018 Vinnitsa, Ukraine., Shishkina S; SSI 'Institute for Single Crystals', National Academy of Sciences of Ukraine, 60 Nauki ave., 61001 Kharkiv, Ukraine.; Department of Inorganic Chemistry, V.N. Karazin Kharkiv National University, 4 Svobody sq., 61077 Kharkiv, Ukraine., Severina H; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine., Grinevich L; Department of Medicinal Chemistry, National University of Pharmacy, 4 Valentynivska st., 61168 Kharkiv, Ukraine., Sim G; Department of Pharmaceutical Chemistry, Far Eastern State Medical University, 35 Murav'eva- Amurskogo st., 680000, Khabarovsk, Russia., Burian K; Department of General Pharmacy and Safety of Drugs, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine., Georgiyants V; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine.

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2023; Vol. 19 (2), pp. 174-192.