Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anna A Marusiak"'
Autor:
Ewelina Testoni, Natalie L Stephenson, Pedro Torres‐Ayuso, Anna A Marusiak, Eleanor W Trotter, Andrew Hudson, Cassandra L Hodgkinson, Christopher J Morrow, Caroline Dive, John Brognard
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 2, Pp 105-116 (2016)
Abstract The lack of actionable mutations in patients with non‐small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this disease. Here, we identify somatically mutated ABL1 as a genetic dependency tha
Externí odkaz:
https://doaj.org/article/09b706bec30d4b42952219ab90a03b7c
Autor:
Dawid Mehlich, Michał Łomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Łukasz M. Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K. Prełowska, Adam Gorczyński, Paweł Jabłoński, Ewa Iżycka-Świeszewska, Dominika Nowis, Anna A. Marusiak
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Abstract Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory p
Externí odkaz:
https://doaj.org/article/a6cbcdae3c1744a89c3691e28b0246d5
Publikováno v:
Endocrine-Related Cancer.
Differentiated thyroid cancers (DTCs) are malignancies that demonstrate strong but largely uncharacterized heritability. Germline variants that influence the risk of DTCs localize in disrupted in renal carcinoma 3 (DIRC3), a poorly described long non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0331fc20278144fa04717638f8756e
https://doi.org/10.1530/erc-23-0058
https://doi.org/10.1530/erc-23-0058
Autor:
John Brognard, Owen J. Sansom, Tony Hunter, Crispin J. Miller, Ewelina Testoni, Matthew Collier, Ross Overman, Isabelle Green, Chris Phillips, Hannah K. Pollard, Claire Brassington, Jon A. Read, Lorena A. Puto, Phil Chapman, Susan Mason, Karen Blyth, Yaoyong Li, Eleanor W. Trotter, Hayeon Baik, Natalie L. Stephenson, Anna A. Marusiak
Supplementary methods. Figure S1. (related to Fig. 1A-F) Analysis of mutations of MLK4 and MLK1 present in CRC cells. Figure S2 (related to Fig. 2 and 3) Structural analysis of MLK4 mutants. Figure S3 (related to Fig. 2 and 3) Structural analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912
https://doi.org/10.1158/0008-5472.22409912
Autor:
Aleksandra Sobiborowicz, Dominika Nowis, Paweł Jabłoński, Agnieszka Borowiec, Anna A Marusiak, Alicja Mazan, Monika K. Prelowska, Dawid Mehlich, Adam Gorczyński, Ewa Iżycka-Świeszewska, Michał Łomiak, Łukasz M. Szewczyk, Dagmara Dymerska, Anna Mehlich
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b457063252e4e9c42d31da83892d59ee
https://doaj.org/article/a6cbcdae3c1744a89c3691e28b0246d5
https://doaj.org/article/a6cbcdae3c1744a89c3691e28b0246d5
Differentiated thyroid cancers (DTCs) are malignancies with ill-defined hereditary predisposition. Some germline variants influencing the risk of DTCs localize indisrupted in renal carcinoma 3(DIRC3), a poorly characterized long non-coding RNA (lncRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839869d7946d46c7b35b0b8270c4ac87
https://doi.org/10.1101/2023.01.24.525402
https://doi.org/10.1101/2023.01.24.525402
Autor:
Dawid Mehlich, Michal Lomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Lukasz M. Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K. Prelowska, Dominika Nowis, Anna A. Marusiak
Publikováno v:
Cancer Research. 82:151-151
Resistance to chemotherapy leads to high rates of relapse and poor outcomes in patients with triple-negative breast cancer (TNBC). Therefore, there is a need to identify novel molecular targets that could be exploited to overcome TNBC chemoresistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a91090b807862ee3b5601ce69196e6b8
https://doi.org/10.1158/1538-7445.am2022-151
https://doi.org/10.1158/1538-7445.am2022-151
Autor:
Hanna Kędzierska, Artur Kosnik, M. Talha Ugurlu, Dominika Nowis, Dawid Mehlich, Anna A. Marusiak, Klaudia Kaminska, Aleksandra Cwiek, Monika K. Prelowska
Publikováno v:
Cancer letters. 507
Proteasome inhibitors (PIs), used in the treatment of plasma cell myeloma (PCM), interfere with the degradation of misfolded proteins leading to activation of unfolded protein response (UPR) and cell death. However, despite initial strong antimyeloma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7166de78ca9911e9a58bb1b8bf8121
https://pubmed.ncbi.nlm.nih.gov/34872789
https://pubmed.ncbi.nlm.nih.gov/34872789
Autor:
Monika K. Prelowska, Dawid Mehlich, M. Talha Ugurlu, Hanna Kedzierska, Aleksandra Cwiek, Artur Kosnik, Klaudia Kaminska, Anna A. Marusiak, Dominika Nowis
Publikováno v:
Cancer Letters. 526:363
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5c586a4fdbdeb00ce5d0e2cbcef418
https://doi.org/10.1016/j.canlet.2021.11.029
https://doi.org/10.1016/j.canlet.2021.11.029
Autor:
Klaudia Kaminska, Hanna Kędzierska, Adam Gorczyński, Dawid Mehlich, Dominika Nowis, Wojciech Biernat, Dariusz Plewczynski, John Brognard, Michal Lazniewski, Aleksandra Korwat, Jakub Golab, Olga Sokolowska, Anna A. Marusiak, Monika K. Prelowska
Publikováno v:
Oncogene
Metastasis to distant organs is a major cause for solid cancer mortality, and the acquisition of migratory and invasive phenotype is a key factor in initiation of malignancy. In this study we investigated the contribution of Mixed-Lineage Kinase 4 (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56504575b4d92ca508d739db572c9d5
https://doi.org/10.1038/s41388-018-0618-0
https://doi.org/10.1038/s41388-018-0618-0