Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Anna Pustilnik"'
Autor:
Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher, Jason R. Chan, Anna Pustilnik, Mark J. Daniels, Young Hoon Kim, Kwee Hyun Suh, Matthew D. Linnik, Young-Mi Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, https://doi.org/10.1186/s13075-016-098
Externí odkaz:
https://doaj.org/article/f84752f1ec4c42a4a963b56dd9003005
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf
Autor:
Ricky Lieu, Stephen Antonysamy, Zhanna Druzina, Carolyn Ho, N Rebecca Kang, Anna Pustilnik, Jing Wang, Shane Atwell
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232311 (2020)
Antibody therapeutics are one of the most important classes of drugs. Antibody structures have become an integral part of predicting the behavior of potential therapeutics, either directly or as the basis of modeling. Structures of Fab:antigen comple
Externí odkaz:
https://doaj.org/article/ebdd6cf4580740df8d79dbe42804a89c
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
LY3295668 chemical characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c3119cab021ba3189b2c2e7d96d2e
https://doi.org/10.1158/2159-8290.22533034.v1
https://doi.org/10.1158/2159-8290.22533034.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
shRNA suppressor screening data for H446 and MDA-MB-468 cells (tabs 1, 2) and RNA expression level associations with LY3295668 Abs IC50 values from 493 cancer cell lines (tab 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7062b69c7f18848d7e882885812c96
https://doi.org/10.1158/2159-8290.22533025.v1
https://doi.org/10.1158/2159-8290.22533025.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071e82c7fa2f25274a31dc41f9817c55
https://doi.org/10.1158/2159-8290.22533037
https://doi.org/10.1158/2159-8290.22533037
Autor:
Xueqian Gong, Jian Du, Stephen H. Parsons, Farhana F. Merzoug, Yue Webster, Philip W. Iversen, Li-Chun Chio, Robert D. Van Horn, Xi Lin, Wayne Blosser, Bomie Han, Shaoling Jin, Sufang Yao, Huimin Bian, Chris Ficklin, Li Fan, Avnish Kapoor, Stephen Antonysamy, Ann M. Mc Nulty, Karen Froning, Danalyn Manglicmot, Anna Pustilnik, Kenneth Weichert, Stephen R. Wasserman, Michele Dowless, Carlos Marugán, Carmen Baquero, María José Lallena, Scott W. Eastman, Yu-Hua Hui, Matthew Z. Dieter, Thompson Doman, Shaoyou Chu, Hui-Rong Qian, Xiang S. Ye, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Robert M. Campbell, James R. Henry, Sean G. Buchanan
Publikováno v:
Cancer Discovery. 9:248-263
Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To identify drugs synthetic lethal with RB1 mutation (RB1mut), we tested 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872b67ff8b99d70e8dd283c21bc27cf8
https://doi.org/10.1158/2159-8290.cd-18-0469
https://doi.org/10.1158/2159-8290.cd-18-0469
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menacherry, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
bioRxiv
SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization when administered early during COVID-19 disease. However, the emergence of variants of concern has negatively impacted the therapeutic use of some authorized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb8cf2c168e04af64aeb77ae8c382f6
https://europepmc.org/articles/PMC8109210/
https://europepmc.org/articles/PMC8109210/
Autor:
Xueqian, Gong, Jian, Du, Stephen H, Parsons, Farhana F, Merzoug, Yue, Webster, Philip W, Iversen, Li-Chun, Chio, Robert D, Van Horn, Xi, Lin, Wayne, Blosser, Bomie, Han, Shaoling, Jin, Sufang, Yao, Huimin, Bian, Chris, Ficklin, Li, Fan, Avnish, Kapoor, Stephen, Antonysamy, Ann M, Mc Nulty, Karen, Froning, Danalyn, Manglicmot, Anna, Pustilnik, Kenneth, Weichert, Stephen R, Wasserman, Michele, Dowless, Carlos, Marugán, Carmen, Baquero, María José, Lallena, Scott W, Eastman, Yu-Hua, Hui, Matthew Z, Dieter, Thompson, Doman, Shaoyou, Chu, Hui-Rong, Qian, Xiang S, Ye, David A, Barda, Gregory D, Plowman, Christoph, Reinhard, Robert M, Campbell, James R, Henry, Sean G, Buchanan
Publikováno v:
Cancer discovery. 9(2)
Loss-of-function mutations in the retinoblastoma gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::788f4412d0d9ac102a757d48661f9d4e
https://pubmed.ncbi.nlm.nih.gov/30737214
https://pubmed.ncbi.nlm.nih.gov/30737214
Autor:
John G. Luz, MatthewW. Carson, Bradley Condon, David Clawson, Anna Pustilnik, Daniel T. Kohlman, Robert J. Barr, James S. Bean, M. Joelle Dill, Dana K Sindelar, Milan Maletic, Michael J. Coghlan
Publikováno v:
Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 16, p6607-6618, 12p