Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

Autor: Clément Paris, Omar Brun, Enrique Pedroso, Anna Grandas

Publikováno v: Molecules, Vol 20, Iss 4, Pp 6389-6408 (2015)

This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic aci

Externí odkaz: https://doaj.org/article/43f397ddbb564c81bd2133fca02dc613

Inverse Electron-Demand Diels–Alder Bioconjugation Reactions Using 7-Oxanorbornenes as Dienophiles

Autor: Enrique Pedroso, Rebecca Ginesi, Anna Grandas, Jordi Agramunt

Publikováno v: The Journal of Organic Chemistry. 85:6593-6604

Oligonucleotides, peptides, and peptide nucleic acids incorporating 7-oxanorbornene as a dienophile were reacted with tetrazines linked to either a peptide, d-biotin, BODIPY, or N-acetyl-d-galactosamine. The inverse electron-demand Diels-Alder (IEDDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1eafc4ed38e95173d9a4d06c20f2ba
https://doi.org/10.1021/acs.joc.0c00583

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

Autor: Omar Brun, Agnès Delaunay-Moisan, Ludovic Pecqueur, Christina S. Müller, Anna Grandas, Jordi Agramunt, Benoît D'Autréaux, Djabir Larkem, Gwenaelle Le Pavec, Sarah Cianférani, Christina Sizun, Volker Schünemann, Sylvain Gervason, Amir Ben Mansour, Michel B. Toledano, Marc Fontecave, Thomas Botzanowski

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.3566. ⟨10.1038/s41467-019-11470-9⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications, 2019, 10, pp.3566. ⟨10.1038/s41467-019-11470-9⟩

Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich’s ataxia caused by impaired expression of frataxin (FXN). Fe-S clusters are biosynthesized on the scaffold prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6ac877a1356c2617c4945b27601d6e
https://doi.org/10.1038/s41467-019-11470-9

Compatibility between the cysteine-cyclopentenedione reaction and the copper(i)-catalyzed azide-alkyne cycloaddition

Autor: Anna Grandas, Jordi Agramunt, Enrique Pedroso, Laia Saltor

Publikováno v: Organicbiomolecular chemistry. 16(47)

The cysteine-cyclopentenedione reaction can be combined with the copper(I)-catalyzed azide–alkyne cycloaddition provided that the former is carried out first. If not, the azide and the cyclopentenedione undergo a 1,3-dipolar cycloaddition, which fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2a704363a6612d9ff2f52758c7c837
https://pubmed.ncbi.nlm.nih.gov/30457146

Fluorescent Nucleoside Derivatives as a Tool for the Detection of Concentrative Nucleoside Transporter Activity Using Confocal Microscopy and Flow Cytometry

Autor: María Pilar Lostao, Carlos Sancho-Mateo, Marçal Pastor-Anglada, Dolors Colomer, Anna Grandas, Paula Fernández-Calotti, Ana Claudio-Montero, Itziar Pinilla-Macua

Publikováno v: Molecular Pharmaceutics. 12:2158-2166

The abundance and function of transporter proteins at the plasma membrane are likely to be crucial in drug responsiveness. Functional detection of human concentrative nucleoside transporters (hCNTs) is of interest for predicting drug sensitivity beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f694ef65c319cac19a0dfc0bfb7a9b10
https://doi.org/10.1021/acs.molpharmaceut.5b00142