Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anna Checchia"'
Autor:
Pan F. Chan, Kaushik Raha, Shruti Jain, Geoffrey Quinque, Margarete Neu, Daniele Andreotti, Roberto Profeta, Reema K. Thalji, Brian Donovan, Simona Tommasi, Lynn McCloskey, Christopher J. Nixon, Giovanni Meneghelli, Tania Bakshi, Anna Checchia, Robert A. Stavenger, Benjamin D. Bax, Alison Howells, Federica Tonelli, Haifeng Cui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1407-1412
A series of DNA gyrase inhibitors were designed based on the X-ray structure of a parent thiophene scaffold with the objective to improve biochemical and whole-cell antibacterial activity, while reducing cardiac ion channel activity. The binding mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63ff5d1f9eeb44a22b39b1dba435047
https://doi.org/10.1016/j.bmcl.2019.03.029
https://doi.org/10.1016/j.bmcl.2019.03.029
Autor:
Thomas Germe, Eric Bacqué, Lynn McCloskey, Kaushik Raha, Haifeng Cui, Anthony Maxwell, Benjamin D. Bax, Reema K. Thalji, Anna Checchia, Dongzhao Chen, Pan F. Chan, Jianzhong Huang, Xiao Ding, Robert A. Stavenger, Velupillai Srikannathasan, Karen A. Ingraham
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0743e12fca822d94a4442ee838e3412
https://doi.org/10.1073/pnas.1700721114
https://doi.org/10.1073/pnas.1700721114
Triazolyl Azabicyclo[3.1.0]hexanes: a Class of Potent and Selective Dopamine D3 Receptor Antagonists
Autor:
Romano Di Fabio, Anna Checchia, Giorgio Bonanomi, Simone Braggio, Silvia Terreni, Luca Tarsi, Angela Worby, Carla Marchioro, Fabrizio Micheli, Christian Heibreder, Anna Maria Capelli, Giovanna Tedesco
Publikováno v:
ChemMedChem. 5:705-715
Herein we report a detailed description of the structure-activity relationships for a novel series of "C-linked" 1,2,4-triazolylazabicyclo[3.1.0]hexanes. These derivatives are endowed with very high in vitro affinity and selectivity for the dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2159ec7e489631396c797199e7448110
https://doi.org/10.1002/cmdc.201000026
https://doi.org/10.1002/cmdc.201000026
Synthesis and Preliminary Biological Characterization of New Semisynthetic Derivatives of Ramoplanin
Autor:
Anna Checchia, Matteo Giannone, Gianbattista Panzone, Augusto Canavesi, Romeo Ciabatti, Franca Castiglione, Gianpaolo Candiani, Sonia I. Maffioli, Elena Michelucci, Paolo Simone Tiseni, Cristina Brunati, Ettore Marzorati, Daniela Jabes, Gabriella Romano
Publikováno v:
Journal of Medicinal Chemistry. 50:3077-3085
Ramoplanin is a glycolipodepsipeptide antibiotic active against Gram-positive bacteria including vancomycin-resistant enterococci. Ramoplanin inhibits bacterial cell wall biosynthesis by a mechanism different from that of glycopeptides and hence does
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0710b9be92762b5747f2794737d740
https://doi.org/10.1021/jm070042z
https://doi.org/10.1021/jm070042z
Autor:
Albert A. Jaxa-Chamiec, Daniele Donati, Silvia Davalli, Fabrizio Micheli, Marilisa Rinaldi, Giorgio Bonanomi, Giovanna Tedesco, Chiara Gallotti, Martyn D. Wood, Silvia Terreni, Marcella Petrone, Graham J. Riley, Federica Damiani, Dieter Hamprecht, Alessandra Pasquarello, Anna Checchia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3906-3912
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT 2C receptor antagonists and the discovery of a new class of potent and selective 5-HT 2C molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ba772e4f2408b566e0d2feffaaa17
https://doi.org/10.1016/j.bmcl.2006.05.034
https://doi.org/10.1016/j.bmcl.2006.05.034
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4566-4568
A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173d603c85c452cf867a3503bbe9ff7d
https://doi.org/10.1016/j.bmcl.2010.06.018
https://doi.org/10.1016/j.bmcl.2010.06.018
Autor:
Mauro Angiolini, Carlo Scolastico, Leonardo Manzoni, Edoardo Cesarotti, L Crippa, Laura Belvisi, S. Araneo, Anna Checchia
Publikováno v:
ResearcherID
In an effort to design dipeptide structural mimics of protein and peptide reverse-turns, a series of 5,5-, 6,5-, and 7,5-fused 2-oxo-1-azabicycloalkane amino acids has been synthesized. A new and convenient synthetic route utilizing a Horner−Emmons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6bdd262760cdab9864df832f1d4d21
https://doi.org/10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co
https://doi.org/10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co
Autor:
Carlo Scolastico, Donatella Potenza, Leonardo Manzoni, Maria Lattanzio, Anna Bernardi, Giovanna Boschin, Anna Checchia
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
The pseudo tetrasaccharide 2 was designed to mimic ganglioside GM1, the membrane receptor of both the cholera toxin and of the heat-labile toxin of E. coli. Compound 2 retains the Gal and Neu5Ac recognition determinant of GM1 and uses as the scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c2f57598f0db1723720bced62b03fa
https://doi.org/10.1002/(sici)1099-0690(199906)1999:6<1311::aid-ejoc1311>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199906)1999:6<1311::aid-ejoc1311>3.0.co
Publikováno v:
Journal of the American Chemical Society. 121:2032-2036
The paper describes the pseudosugar 2 [Galβ1−3GalNAcβ1−4(NeuAcα2−3)DCCHD], a high affinity binder of cholera toxin (CT). The molecule was designed using molecular modeling techniques to mimic the natural CT membrane receptor, ganglioside GM1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b769d35d9ba9548a85814773cb4cebbe
https://doi.org/10.1021/ja983567c
https://doi.org/10.1021/ja983567c
Autor:
Daniele Andreotti, Letizia Bettelini, Anna Checchia, Alessandro Zocchi, Beatrice Oliosi, Luca Tarsi, Emiliangelo Ratti, Filippo Visentini, Ilaria Sartori, Simone Spada, Carla Marchioro, Giorgio Bonanomi, Emilio Merlo-Pich, Elettra Fazzolari, Romano Di Fabio, Mauro Corsi, Stefano Fontana, Simone Braggio, Barbara Bertani, Roberto Benedetti, Michela Bettati, Paolo Cavanni, Kevin D. Read, Giovanna Tedesco, Maja Roscic, Silvia Terreni, Fabrizio Micheli, Roberto Arban, Laura Zonzini, Michele Negri, Renzo Carletti
Publikováno v:
Journal of medicinal chemistry. 53(13)
A pharmacophore model for triple reuptake inhibitors and the new class of 1-(aryl)-6-[alkoxyalkyl]-3- azabicyclo[3.1.0]hexanes were recently reported. Further investigation in this area led to the identification of a new series of potent and selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6065c75cf3b0fac2702515c5ed7e7278
https://pubmed.ncbi.nlm.nih.gov/20527970
https://pubmed.ncbi.nlm.nih.gov/20527970