Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Anna‐Liisa Levonen"'
Autor:
Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen, Tommi Patinen, Xiaonan Liu, Tuomo Laitinen, Piia Takabe, Kirsi Kainulainen, Sanna Pasonen-Seppänen, Lisa M. Gawriyski, Uma Thanigai Arasu, Ilakya Selvarajan, Petri Mäkinen, Hanna Laitinen, Emilia Kansanen, Minna U. Kaikkonen, Antti Poso, Markku Varjosalo, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103031- (2024)
The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently constitutively
Externí odkaz:
https://doaj.org/article/6424cb4692934e1e8076ab053da688af
Autor:
Sarang S. Talwelkar, Mikko I. Mäyränpää, Julia Schüler, Nora Linnavirta, Annabrita Hemmes, Simone Adinolfi, Matti Kankainen, Wolfgang Sommergruber, Anna‐Liisa Levonen, Jari Räsänen, Aija Knuuttila, Emmy W. Verschuren, Krister Wennerberg
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 747-764 (2023)
Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged tumors. However, clinical resistance typically develops over time and, in the majority
Externí odkaz:
https://doaj.org/article/1563d14766b740a0a1ffecc8176e6bc3
Autor:
Simone Adinolfi, Tommi Patinen, Ashik Jawahar Deen, Sini Pitkänen, Jouni Härkönen, Emilia Kansanen, Jenni Küblbeck, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102726- (2023)
The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, m
Externí odkaz:
https://doaj.org/article/b9ce4d24942d4266829fce396e5ff767
Autor:
Miika Mehine, Terhi Ahvenainen, Sara Khamaiseh, Jouni Härkönen, Siiri Reinikka, Tuomas Heikkinen, Anna Äyräväinen, Päivi Pakarinen, Päivi Härkki, Annukka Pasanen, Anna-Liisa Levonen, Ralf Bützow, Pia Vahteristo
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting MED12, HMGA2, or FH. FH-deficient lei
Externí odkaz:
https://doaj.org/article/199d3f3126b54a4fbad0c263ac974ff4
Autor:
Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y. Dimova, Thomas Kietzmann, Maarit Ahtiainen, Juha P. Väyrynen, Sara A. Väyrynen, Hanna Elomaa, Niko Tynkkynen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U. Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102644- (2023)
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of
Externí odkaz:
https://doaj.org/article/9ac1335b051440bd822ee925a02cdeed
Autor:
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Externí odkaz:
https://doaj.org/article/623c13f35ca24a70a5117e36da09403d
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 77-83 (2018)
Oxidative stress predisposes to several aging-associated diseases, such as cardiovascular diseases and cancer. In aging, increase in the production of reactive oxygen species is typically accompanied with a decline in adaptive stress responses to oxi
Externí odkaz:
https://doaj.org/article/14ee52fdebf1425f9979c07fdf694ff5
Autor:
Tommi Patinen, Simone Adinolfi, Carlos Cruz Cortés, Jouni Härkönen, Ashik Jawahar Deen, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 23, Iss , Pp - (2019)
Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive signaling pat
Externí odkaz:
https://doaj.org/article/8d33041e0f964b5d8217790667fc8742
Autor:
Suvi Jauhiainen, Johanna P. Laakkonen, Kirsi Ketola, Pyry I. Toivanen, Tiina Nieminen, Takeshi Ninchoji, Anna-Liisa Levonen, Minna U. Kaikkonen, Seppo Ylä-Herttuala
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Vascular endothelial growth factors (VEGFs) are key mediators of endothelial cell (EC) function in angiogenesis. Emerging knowledge also supports the involvement of axon guidance-related factors in the regulation of angiogenesis and vascular patterni
Externí odkaz:
https://doaj.org/article/f2c61d3554834120acd95abb744ff1d3
Autor:
Jenni Küblbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 3021 (2020)
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been
Externí odkaz:
https://doaj.org/article/ff26a03b74de4fce88dd9c25a9c96461