Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anna, Suchankova"'
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Margarita Stampelou, Anna Suchankova, Efpraxia Tzortzini, Lakshiv Dhingra, Kerry Barkan, Nikolaos Lougiakis, Panagiotis Marakos, Nicole Pouli, Graham Ladds, Antonios Kolocouris
Publikováno v:
Journal of Medicinal Chemistry. 65:13305-13327
Drugs targeting adenosine receptors (AR) can provide treatment for diseases. We report the identification of 7-(phenylamino)-pyrazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cbf037699932a3c0db6add10cb34c7
https://doi.org/10.1021/acs.jmedchem.2c01123
https://doi.org/10.1021/acs.jmedchem.2c01123
Autor:
Anna Suchankova, Margarita Stampelou, Klontiana Koutsouki, Athanasios Pousias, Lakshiv Dhingra, Kerry Barkan, Nicole Pouli, Panagiotis Marakos, Roxane Tenta, Antonios Kolocouris, Nikolaos Lougiakis, Graham Ladds
Publikováno v:
ACS Medicinal Chemistry Letters. 13:923-934
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd741dab512bf598fa4a68699eeb8eb
https://doi.org/10.1021/acsmedchemlett.2c00052
https://doi.org/10.1021/acsmedchemlett.2c00052
Autor:
Barbara, Preti, Anna, Suchankova, Giuseppe, Deganutti, Michele, Leuenberger, Kerry, Barkan, Iga, Manulak, Xianglin, Huang, Sabrina, Carvalho, Graham, Ladds, Martin, Lochner
Publikováno v:
Journal of medicinal chemistry. 65(21)
A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fef5ba6c4d64e47165cbcd7955c7afd
https://pubmed.ncbi.nlm.nih.gov/36270633
https://pubmed.ncbi.nlm.nih.gov/36270633
Autor:
Margarita Stampelou, Anna Suchankova, Efpraxia Tzortzini, Lakshiv Dhingra, Kerry Barkan, Nikolaos Lougiakis, Panagiotis Marakos, Nikole Pouli, Graham Ladds, Antonios Kolocouris
Drugs targeting the four adenosine receptor (AR) subtypes can provide “soft" treatment of various significant diseases. Even for the two experimentally resolved AR subtypes the description of the orthosteric binding area and structure-activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793e59c20c9bb6aa37c446f9926b92df
https://doi.org/10.26434/chemrxiv-2021-j18mg-v2
https://doi.org/10.26434/chemrxiv-2021-j18mg-v2
Publikováno v:
Methods in cell biology. 166
The importance of receptor-ligand binding kinetics has often been overlooked during drug development, however, over the past decade it has become increasingly clear that a better understanding of the kinetic parameters is crucial for fully evaluating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ade491777472e89ee9c7747f12c0db42
https://pubmed.ncbi.nlm.nih.gov/34752328
https://pubmed.ncbi.nlm.nih.gov/34752328
Publikováno v:
Biomolecular Interactions Part A ISBN: 9780128233511
The importance of receptor-ligand binding kinetics has often been overlooked during drug development, however, over the past decade it has become increasingly clear that a better understanding of the kinetic parameters is crucial for fully evaluating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a0538bd28505649a2be8a6314f20f60
https://doi.org/10.1016/bs.mcb.2021.06.013
https://doi.org/10.1016/bs.mcb.2021.06.013
Autor:
Mark J, Wall, Emily, Hill, Robert, Huckstepp, Kerry, Barkan, Giuseppe, Deganutti, Michele, Leuenberger, Barbara, Preti, Ian, Winfield, Sabrina, Carvalho, Anna, Suchankova, Haifeng, Wei, Dewi, Safitri, Xianglin, Huang, Wendy, Imlach, Circe, La Mache, Eve, Dean, Cherise, Hume, Stephanie, Hayward, Jess, Oliver, Fei-Yue, Zhao, David, Spanswick, Christopher A, Reynolds, Martin, Lochner, Graham, Ladds, Bruno G, Frenguelli
Publikováno v:
Nature communications. 13(1)
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa941f335f351aaf8baa573ea9efddc
https://pubmed.ncbi.nlm.nih.gov/35851064
https://pubmed.ncbi.nlm.nih.gov/35851064