Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia

Autor: Fatemah Rezayee, Jesper Eisfeldt, Aron Skaftason, Ingegerd Öfverholm, Shumaila Sayyab, Ann Christine Syvänen, Khurram Maqbool, Henrik Lilljebjörn, Bertil Johansson, Linda Olsson-Arvidsson, Christina Orsmark Pietras, Anna Staffas, Lars Palmqvist, Thoas Fioretos, Lucia Cavelier, Linda Fogelstrand, Jessica Nordlund, Valtteri Wirta, Richard Rosenquist, Gisela Barbany

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionThe suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic methods.Metho

Externí odkaz: https://doaj.org/article/40bdae45ba894ef6ae31e5164ee7f34f

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia

Autor: Edith Schneider, Anna Staffas, Linda Röhner, Erik D. Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I. Petriv, Alireza Heravi-Moussavi, Carl L. Hansen, Martin Hirst, R. Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer

Publikováno v: Haematologica, Vol 103, Iss 2 (2018)

Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155

Externí odkaz: https://doaj.org/article/87401d72d1534be9b48a6f1e53390dbc

Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b

Autor: Mohamed X. Ibrahim, Anna Staffas, Volkan I. Sayin, Per Lindahl, Christin Karlsson, Murali K. Akula, Martin O. Bergo, Jaroslaw Cisowski

Publikováno v: Leukemia. 35:606-609

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da3302463463b6588d6a8250e3691425
https://doi.org/10.1038/s41375-020-0859-0

Lactose drives Enterococcus expansion to promote graft-versus-host disease

Autor: Ying Taur, Lauren Bohannon, Sean M. Devlin, Daniela Weber, M. A. Jamal, Koji Hayasaka, Melissa D. Docampo, Emily Fontana, D. Pham, Nelson J. Chao, Daigo Hashimoto, Jonathan U. Peled, R. Pinedo, Meagan V. Lew, Joao B. Xavier, Eric G. Pamer, C. Scheid, Anna Staffas, C. K. Stein-Thoeringer, Sergio Giralt, D. Bajic, Molly Maloy, Luigi A Amoretti, G. Armijo, Yusuke Shono, Anthony D. Sung, A. Lazrak, Yuta Hasegawa, Roberta J. Wright, Alessandro Pastore, M. Burgos da Silva, A. Tsakmaklis, J. B. Slingerland, Robert R. Jenq, Ernst Holler, M. E. Arcila, Doris M. Ponce, Kate A. Markey, Annelie Clurman, Julia A. Messina, Antonio L.C. Gomes, Ann E. Slingerland, Eric R. Littmann, M.R.M. van den Brink, Amy Bush, Sebastien Monette, Miguel-Angel Perales, Takanori Teshima, Amanda J. Pickard, Kristi Romero, M. J. G. T. Vehreschild, K. B. Nichols, Justin R. Cross

Publikováno v: Science

Lactose can fuel GVHD Allogeneic hematopoietic cell transplantation (allo-HCT) is used to treat certain hematopoietic malignancies, but patients have a risk of developing graft-versus-host disease (GVHD). Stein-Thoeringer et al. performed a large-sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f03718c70327d6bd8d5c73142ca9537
https://doi.org/10.1126/science.aax3760

DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)

Autor: Anna Staffas, Rolf Larsson, Kirsi Jahnukainen, Jonas Abrahamsson, Lars Palmqvist, Olafur G. Jonsson, Jessica Nordlund, Christofer Bäcklin, Birgitte Lausen, Bernward Zeller, Josefine Palle, Ulrika Norén-Nyström, Randi Hovland, Olga Krali, Henrik Hasle

Publikováno v: Genes, Vol 12, Iss 895, p 895 (2021)
Krali, O, Palle, J, Bäcklin, C L, Abrahamsson, J, Norén-Nyström, U, Hasle, H, Jahnukainen, K, Jónsson, Ó G, Hovland, R, Lausen, B, Larsson, R, Palmqvist, L, Staffas, A, Zeller, B & Nordlund, J 2021, ' Dna methylation signatures predict cytogenetic subtype and outcome in pediatric acute myeloid leukemia (Aml) ', Genes, vol. 12, no. 6, 895 . https://doi.org/10.3390/genes12060895
Genes
Volume 12
Issue 6

Pediatric acute myeloid leukemia (AML) is a heterogeneous disease composed of clinically relevant subtypes defined by recurrent cytogenetic aberrations. The majority of the aberrations used in risk grouping for treatment decisions are extensively stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d8227e30737ce03abc09445eccebf6
https://www.mdpi.com/2073-4425/12/6/895